Cited by 385Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task

Logue, Sheree F., Paylor, Richard, Wehner, Jeanne M.·1997·Behavioral Neuroscience

Abstract

This study examined the effect of hippocampal lesions on acquisition of the Morris water maze and conditioned-fear task in inbred mice. C57BL/6J, DBA/2J, and B6D2F1 hybrid mice were given hippocampal lesions or sham surgery and then tested. The lesioned C57BL/6J and B6D2F1 mice failed to learn the Morris task relative to sham-operated controls, and no DBA group learned the task. In the contextual component of conditioned fear, lesions decreased freezing in all strains. But the lesions only affected freezing to the conditioned stimulus in the DBA/2J and B6D2F1 strains. These data demonstrate that C57BL/6J and B6D2F1 mice use the hippocampus to solve the Morris water maze and conditioned-fear task, and the DBA mice use the hippocampus, to some degree, in the conditioned-fear task.

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Crossref · 10.1037/0735-7044.111.1.104

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Authors
Logue, S. F., Paylor, R., & Wehner, J. M.
Affiliations
University of Colorado Boulder (US)
Venue
Behavioral Neuroscience
Published
1997-02
Volume
111
Issue
1
Pages
104-113
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2088024567
Cited by
385
References
37
Citations by year
2026: 1 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 5 · 2016: 17 · 2015: 12 · 2014: 24 · 2013: 17 · 2012: 21
FWCI
12.04
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh048663-05)
  • National Institute of Mental Health (MH-48663)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (5T32HD-07289, T32HD007289)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampal lesions, hippocampus, spatial learning, Morris water maze, fear conditioning, contextual fear, freezing behavior, inbred mouse strains, C57BL/6J mice, DBA/2J, strain differences, learning deficits
MeSH terms
Animals, Association Learning, Cerebral Cortex, Conditioning, Classical, Escape Reaction, Fear, Hippocampus, Male, Mice, Inbred Strains, Motor Activity, Neural Pathways, Problem Solving, Mental Recall, Species Specificity, Maze Learning, Mice

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