Cited by 113Neuroendocrine regulation and behaviorHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Gonadal steroids have paradoxical effects on brain oxytocin receptors

Insel, Thomas R., Young, Larry, Witt, Diane M., Crews, David·1993·Journal of Neuroendocrinology

Abstract

Specific brain receptors for oxytocin have been described in several mammalian species. The distribution of these receptors differs greatly across species and in the rat, receptor binding in specific brain regions appears to depend upon gonadal steroids. This study used in vitro receptor autoradiography to examine the effects of testosterone on oxytocin receptor binding in the mouse forebrain. Three groups of male mice were compared: castrates treated with blank capsules, castrates treated with testosterone filled capsules, and intact males. Irrespective of steroid treatment, the distribution of oxytocin receptors in mouse forebrain differed markedly from patterns previously described in the rat. In addition to these species differences in receptor distribution, testosterone had effects in the mouse which differed from the induction of receptors previously reported in the rat. In the mouse ventromedial nucleus of the hypothalamus, binding in the untreated castrate males was approximately double that observed in either the intact or the testosterone-treated castrates. In other regions of the mouse brain, such as the intermediate zone of the lateral septum, binding to oxytocin receptors was increased with testosterone treatment. These results suggest that the brain oxytocin receptor varies across species not only in its distribution but also in its regional regulation by gonadal steroids. These apparently paradoxical changes in oxytocin receptor binding may result from either direct or indirect effects of gonadal steroids in mouse brain.

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Crossref · 10.1111/j.1365-2826.1993.tb00531.x

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Authors
Insel, T. R., Young, L., Witt, D. M., & Crews, D.
Affiliations
  • National Institute of Mental Health (US)
  • National Institutes of Health (US)
Corresponding author
Insel, Thomas R.
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
1993-12
Volume
5
Issue
6
Pages
619-628
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W2098078316
Cited by
113
References
67
Citations by year
2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 10 · 2012: 4
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (NIMH-41770, NIMH00135)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin receptor, sex steroids, testosterone, castration, forebrain, ventromedial hypothalamus, lateral septum, species differences, receptor binding, mice
MeSH terms
Animals, Autoradiography, Brain, Brain Chemistry, Arvicolinae, Guinea Pigs, Cricetinae, Humans, Iodine Radioisotopes, Mesocricetus, Oxytocin, Peromyscus, Radioimmunoassay, Gonadal Steroid Hormones, Species Specificity, Testosterone, Receptors, Oxytocin, Mice, Rats

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