The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Enhanced Neurofibrillary Tangle Formation, Cerebral Atrophy, and Cognitive Deficits Induced by Repetitive Mild Brain Injury in a Transgenic Tauopathy Mouse Model
Abstract
Traumatic brain injury (TBI) is a risk factors for Alzheimer's disease (AD), and repetitive TBI (rTBI) may culminate in dementia pugilistica (DP), a syndrome characterized by progressive dementia, parkinsonism, and the hallmark brain lesions of AD, including neurofibrillary tangles (NFTs), formed by abnormal tau filaments and senile plaques (SPs) composed of Abeta fibrils. Previous study showed that mild rTBI (mrTBI) accelerated the deposition of Abeta in the brains of transgenic (Tg) mice (Tg2576) that over-express human Abeta precursor proteins with the familial AD Swedish mutations (APP695swe) and model of AD-like amyloidosis. Here, we report studies of the effects of mrTBI on AD-like tau pathologies in Tg mice expressing the shortest human tau isoform (T44) subjected to mrTBI, causing brain concussion without structural brain damage to simulate injuries linked to DP. Twelve-month-old Tg T44 (n = 18) and wild-type (WT; n = 24) mice were subjected to mrTBI (four times a day, 1 day per week, for 4 weeks; n = 24) or sham treatment (n = 18). Histopathological analysis of mice at 9 months after mrTBI revealed that one of the Tg T44 mice showed extensive telencephalic NFT and cerebral atrophy. Although statistical analysis of neurobehavioral tests at 6 months after mrTBI did not show any significant difference in any of groups of mice, the Tg T44 mouse with extensive NFT had an exceptionally low neurobehavioral score. The reasons for the augmentation of tau pathologies in only o…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, only transgenic tau mouse models [T44 (one mouse), hTau] displayed NFT pathology following repetitive TBI (153, 234).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [234]
Citations
Cites
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
A controlled cortical impact model of traumatic brain injury in the rat
Edward Dixon, C., Clifton, G. L., Lighthall, J. W., Yaghmai, A. A., & Hayes, R. L. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90104-8 · Cited by 1,141
Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J. (2001) · Acta Neuropathologica · doi:10.1007/s004010000330 · Cited by 230
Self-citationTau immunohistochemistry in acute brain injury
Smith, C., Graham, D. I., Murray, L. S., & Nicoll, J. A. R. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00488.x · Cited by 110 · cited 1×
“…clinically by a progressive dementia with parkinsonism, as well as postmortem evidence of abundant senile plaques (SPs) formed by A deposits and neurofibrillary tangles (NFTs) composed of abnormal tau filaments similar to AD (Geddes et al., 1996; Schmidt et al., 2001; Smith et al., 2003).”
Research works printed but not linked: 18
- 10.1136/jnnp.52.5.600 · DOI
- 10.1523/JNEUROSCI.22-21-09340.2002 · DOI
- 10.1159/000112903 · DOI
- 10.3233/JAD-2004-6208 · DOI
- 10.1093/ajcn/71.2.621s · DOI
- 10.1046/j.1365-2990.1996.2598025.x · DOI · Paper page
- 10.1016/S0896-6273(00)81127-7 · DOI · Paper page
- 10.1016/S0002-9440(10)63997-1 · DOI
- 10.3171/jns.2001.95.5.0859 · DOI · Paper page
- 10.1038/78078 · DOI · Paper page
- 10.1227/01.NEU.0000149008.73513.44 · DOI
- 10.1089/cns.1987.4.119 · DOI
- 10.1016/0306-4522(89)90247-9 · DOI
- 10.1002/(SICI)1096-9861(19980323)392:4<428::AID-CNE2>3.0.CO;2-2 · DOI
- 10.1097/00004647-199907000-00006 · DOI
- 10.1089/neu.1995.12.169 · DOI · Paper page
- 10.1523/JNEUROSCI.22-02-00446.2002 · DOI · Paper page
- 10.1046/j.1471-4159.2002.t01-1-01061.x · DOI · Paper page
Cited by
Sorted by citations
Items 101–125 of 125
To, X. V., Soni, N., Medeiros, R., Alateeq, K., & Nasrallah, F. A. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147955 · Cited by 8
Soni, N., Medeiros, R., Alateeq, K., To, X. V., & Nasrallah, F. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.611451 · Cited by 8
“Clinicopathological studies show that NFTs are associated with brain function loss and the cognitive deficits reported in TBI and AD with the density of NFTs reflecting the degree of dementia (Yoshiyama et al., 2005; Johnson et al., 2016; Buckley et al., 2017).”
BackgroundJamerlan, A., Dominguez, J. C., Ligsay, A. D., Youn, Y. C., An, S. S. A., & Kim, S. (2019) · Molecular & Cellular Toxicology · doi:10.1007/s13273-019-0039-3 · Cited by 5
Altered Tau Kinase Activity in rTg4510 Mice after a Single Interfaced CHIMERA Traumatic Brain Injury
Cheng, W. H., Cheung, H., Kang, A., Fan, J., Cooper, J. G., Anwer, M., Barrón, C., Wilkinson, A., Hu, G., Yue, J., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119439 · Cited by 6
“[12] induced repetitive closed head impacts (16×, 4 times per day, 1 day per week) to 12-mo Tg T44 mice, overexpressing the shortest human tau isoform T44.”
BackgroundTran, H. (2011) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7gb223z
“overexpress either mutated forms of APP or tau, not both (Smith et al., 1998; Uryu et al., 2002; Yoshiyama et al., 2005).”
BackgroundMethodInfluentialShin, S. S., Mazandi, V. M., Schneider, A. L. C., Morton, S., Starr, J. P., Weeks, M. K., Widmann, N. J., Jang, D. H., Kao, S.-H., Ahlijanian, M. K., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11071807 · Cited by 5
“Larger oligomers can then form neurofibrillary tangles in various brain regions, which has also been demonstrated in TBI [25,26], Alzheimer’s disease [27], and other neurodegenerative conditions.”
BackgroundOjo, J. O., Leary, P., Lungmus, C., Algamal, M., Mouzon, B., Bachmeier, C. J., MULLAN, M. J., Stewart, W. B., Jr., & Crawford, F. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly101 · Cited by 3
Lacivita, E., Stama, M. L., Maeda, J., Fujinaga, M., Hatori, A., Zhang, M., Colabufo, N. A., Perrone, R., Higuchi, M., Suhara, T., et al. (2016) · Chemistry & Biodiversity · doi:10.1002/cbdv.201500281 · Cited by 4
Self-citationRepetitive stretching enhances the formation of neurite swellings in cultured neuronal cells
Nakadate, H., Kurtoğlu, E., Shirasaki, S., & Aomura, S. (2016) · doi:10.15761/imm.1000231 · Cited by 2
Robey, C., Grillakis, A. A., Fan, A. X., Liu, J., Tucker, L. B., Fu, A. H., Kim, Y., & McCabe, J. T. (2025) · Neurotrauma Reports · doi:10.1089/neur.2024.0168 · Cited by 1
An implantable helmet for studying repeat TBI
Ondek, K., Lucero, S., Zwienenberg, M., & Gurkoff, G. G. (2020) · MethodsX · doi:10.1016/j.mex.2020.101142 · Cited by 1
Development of In Vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury
Brody, D., & Diamond, M. I. (2014) · doi:10.21236/ada596727 · Cited by 1
Imaging Biomarkers for Diagnosis, Prognosis, and Treatment of Alzheimer’s Disease
Wegrzyn, R. D., & Rudolph, A. S. (2012) · CRC Press eBooks · doi:10.1201/b11986-9 · Cited by 1
Current Understanding and Experimental Approaches to the Study of Repetitive Brain Injury
John, T. (2012) · InTech eBooks · doi:10.5772/27685 · Cited by 1
“…now been conducted over the past decade (Allen et al., 2000; Conte et al., 2004; Creeley et al., 2004; DeFord et al., 2002; Friess et al., 2009; Huh et al., 2007; Laurer et al., 2001; Longhi et al., 2005; Raghupathi et al., 2004; Shitaka et al., 2011; Uryu et al., 2002; Yoshiyama et al., 2005).”
BackgroundMethodInfluentialTakashima, A. (2010) · Advances in neurobiology · doi:10.1007/978-1-4419-6787-9_5 · Cited by 1
A model of repetitive mild brain injury without symptoms – risk for Parkinson’s disease with aging?Preprint
Kulkarni, P., Morrison, T. R., Cai, X., Iriah, S., Lang, M. S., Kennedy, L., Sabrick, J., Neuroth, L., Hoffman, G. E., & Ferris, C. F. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/390856 · Cited by 1
Hall, N. M., Seidenberg, P., & Goeders, N. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07162-0
Chronic Traumatic Encephalopathy Among Athletes
He, E. W. (2022) · Scholarly Review Journal · doi:10.70121/001c.121658
“However, research has indicated that following traumatic brain injuries, the iron from bleeding is correlated to the formation of NTFs but are more associated with multiple mTBIs rather than one severe injury, overlapping the causes of CTE (Yoshiyama et. al, 2005).”
BackgroundAltered tau in rTg4510 mice after a single interfaced CHIMERA traumatic brain injuryPreprint
Cheng, W. H., Cheung, H., Kang, A., Fan, J., Cooper, J. G., Anwer, M., Barrón, C., Wilkinson, A., Hu, G., Yue, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.01.506145
What Happens to Concussed Animals?
Victoroff, J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139696432.006
Genetics and Pathology of Chronic Traumatic Encephalopathy
Krafjack, L. L., & Raghupathi, R. (2015) · Current Genetic Medicine Reports · doi:10.1007/s40142-015-0082-x
“Despite the plethora of animal models of repetitive mild TBI, the use of mice in repetitive TBI has one major limitation: mice do not form neurofibrillary tangles and no non-transgenic model has been capable of recapitulating the pathological finding of tau tangles [20].”
BackgroundPathological Tau as a Cause, and Consequence, of Cellular Dysfunction
Meier, S. E. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.368
“Interestingly, NFT formation has not been observed in models of TBI using mice that only express endogenous tau [268].”
BackgroundMethodInfluentialElucidating and Pharmacologically Targeting Secondary Injury Cascades following Neural Injury
Lucke-Wold, B. P. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6120
TITLE : Development of in vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury
Diamond, M. I., & Brody, D. (2014) · doi:10.21236/ada614235
Lessons in Modeling, Preventing, and Treating Neural Injury: Improving Bench-to- Bedside Translation
Turner, R. C. (2013) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.3665
Metadata
- Authors
- Yoshiyama, Y., Uryu, K., Higuchi, M., Longhi, L., Hoover, R., Fujimoto, S., McIntosh, T., Lee, V. M.-Y., & Trojanowski, J. Q.
- Affiliations
- University of Pennsylvania (US)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- ORCID
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2005-10
- Volume
- 22
- Issue
- 10
- Pages
- 1134-1141
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2059869018
- Cited by
- 133
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 4
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (P50NS008803, NS P50-08803, NS R01-40978)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- repetitive mild traumatic brain injury, chronic traumatic encephalopathy, neurofibrillary tangles, tau pathology, brain atrophy, cognitive impairment, concussion, Alzheimer's disease, transgenic mouse model, amyloid-beta, amyloid plaques
- MeSH terms
- Animals, Atrophy, Brain Injuries, Cerebral Cortex, Cognition Disorders, Disease Models, Animal, Humans, Immunohistochemistry, Mice, Transgenic, Blotting, Western, Neurofibrillary Tangles, tau Proteins, Maze Learning, Tauopathies, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
