The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Both Hypoxemia and Extreme Hyperoxemia May Be Detrimental in Patients with Severe Traumatic Brain Injury
Abstract
An association between hypoxemia and poor outcomes from traumatic brain injury (TBI) is well documented. However, it is unclear whether hyperoxygenation is beneficial. This registry-based analysis explores the relationship between early hypoxemia and hyperoxemia on outcome from moderate-to-severe TBI. TBI patients (Abbreviated Injury Scale score 3+) were identified from the San Diego County trauma registry. Patients were stratified by arrival partial oxygen pressure (Po(2)) value. Trauma and injury severity score (TRISS) was then used to calculate predicted survival for each patient, with the mean observed-predicted survival differential determined for each arrival Po(2) stratification. Logistic regression was used to quantify the relationship between hypoxemia, hyperoxemia, and outcome from TBI after adjusting for multiple variables including intubation and ventilation status. A total of 3420 patients were included in the analysis. TRISS calculations revealed worse outcomes than predicted for both hypoxemia and extreme hyperoxemia. Logistic regression revealed an optimal Po(2) range (110-487 mm Hg), with an independent association observed between decreased survival and both hypoxemia (OR 0.54; 95% CI 0.42, 0.69; p < 0.001) and extreme hyperoxemia (OR 0.50; 95% CI 0.36, 0.71; p < 0.001). The association between hypoxemia and extreme hyperoxemia and worse outcomes was also present with use of "good outcomes" as the outcome variable (discharge to home, rehabilitation, jail, or psychiatric facility, or leaving against medical advice). We conclude that both hypoxemia and extreme hyperoxemia are associated with increased mortality and a decrease in good outcomes among TBI patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bouma, G. J., Muizelaar, J. P., Stringer, W. A., Choi, S. C., Fatouros, P., & Young, H. F. (1992) · Journal of Neurosurgery · doi:10.3171/jns.1992.77.3.0360 · Cited by 549
Smith, D. S. (1993) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-199301000-00013 · Cited by 467
Chesnut, R. M., Marshall, S. B., Piek, J., Blunt, B. A., Klauber, M. R., & Marshall, L. F. (1993) · Monitoring of Cerebral Blood Flow and Metabolism in Intensive Care · doi:10.1007/978-3-7091-9302-0_21 · Cited by 414
Continuous Monitoring of Partial Pressure of Brain Tissue Oxygen in Patients with Severe Head Injury
van Santbrink, H., Maas, A. I. R., & Avezaat, C. J. J. (1996) · Neurosurgery · doi:10.1097/00006123-199601000-00007 · Cited by 389
The effect of hypotension and hypoxia on children with severe head injuries
Pigula, F. A., Wald, S. L., Shackford, S. R., & Vane, D. W. (1993) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(93)90223-8 · Cited by 336
Should Stroke Victims Routinely Receive Supplemental Oxygen?: A Quasi-Randomized Controlled Trial
Rønning, O. M., & Guldvog, B. (1999) · Stroke · doi:10.1161/01.str.30.10.2033 · Cited by 313
Davis, D. P., Dunford, J. V., Poste, J. C., Ochs, M., Holbrook, T., Fortlage, D., Size, M. J., Kennedy, F., & Hoyt, D. B. (2004) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000135503.71684.c8 · Cited by 307
Self-citationA Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke
Singhal, A. B., Benner, T., Roccatagliata, L., Koroshetz, W. J., Schaefer, P. W., Lo, E. H., Buonanno, F. S., Gonzalez, R. G., & Sorensen, A. G. (2005) · Stroke · doi:10.1161/01.str.0000158914.66827.2e · Cited by 280
Out-of-hospital endotracheal intubation and outcome after traumatic brain injury
Wang, H. E., Peitzman, A. B., Cassidy, L. D., Adelson, P. D., & Yealy, D. M. (2004) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2004.04.008 · Cited by 276
The OPALS Major Trauma Study: impact of advanced life-support on survival and morbidity
Stiell, I. G., Nesbitt, L. P., Pickett, W., Munkley, D., Spaite, D. W., Banek, J., Field, B., Luinstra-Toohey, L., Maloney, J., Dreyer, J., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.071154 · Cited by 266
Cited by
Singer, M., Young, P. J., Laffey, J. G., Asfar, P., Taccone, F. S., Skrifvars, M. B., Meyhoff, C. S., & Radermacher, P. (2021) · Critical Care · doi:10.1186/s13054-021-03815-y · Cited by 282
Mayglothling, J., Duane, T. M., Gibbs, M., McCunn, M., Legome, E., Eastman, A. L., Whelan, J., & Shah, K. H. (2012) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0b013e31827018a5 · Cited by 200
Bench-to-bedside review: the effects of hyperoxia during critical illness
Helmerhorst, H. J. F., Schultz, M. J., van der Voort, P. H. J., de Jonge, E., & van Westerloo, D. J. (2015) · Critical Care · doi:10.1186/s13054-015-0996-4 · Cited by 187
Metadata
- Authors
- Davis, D. P., Meade, W., Sise, M. J., Kennedy, F., Simon, F., Tominaga, G., Steele, J., & Coimbra, R.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2009-12
- Volume
- 26
- Issue
- 12
- Pages
- 2217-2223
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2027706964
- Cited by
- 271
- References
- 40
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Both Hypoxemia and Extreme Hyperoxemia May Be Detrimental in Patients with Severe Traumatic Brain Injury. https://app.cochat.ai/papers/10.1089/neu.2009.0940
- The paper
- Davis, D. P., Meade, W., Sise, M. J., Kennedy, F., Simon, F., Tominaga, G., Steele, J., & Coimbra, R. (2009). Both Hypoxemia and Extreme Hyperoxemia May Be Detrimental in Patients with Severe Traumatic Brain Injury. Journal of Neurotrauma. https://doi.org/10.1089/neu.2009.0940
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
