The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Dangers of hyperoxia
Open accessAbstract
Oxygen (O 2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS).Supplemental O2, i.e. inspiratory O 2 concentrations (F I O 2) > 0.21 may cause hyperoxaemia(i.e. arterial (a) PO 2 > 100 mmHg) and, subsequently,hyperoxia(increased tissue O 2 concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O 2 toxicity and the potential harms of supplemental O 2 in various ICU conditions. The current evidence base suggests that PaO 2 > 300 mmHg (40 kPa) should be avoided, but it remains uncertain whether there is an “optimal level” which may vary for given clinical conditions. Since even moderately supra-physiological PaO 2 may be associated with deleterious side effects, it seems advisable at present to titrate O 2 to maintain PaO 2 within the normal range, avoiding both hypoxaemia and excess hyperoxaemia.
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Cites
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Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
H 2 O 2 , a Necessary Evil for Cell Signaling
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European Resuscitation Council Guidelines for Resuscitation 2015
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Supplemental Perioperative Oxygen to Reduce the Incidence of Surgical-Wound Infection
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Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient
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Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries
Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani-Cavalieri, I., Porto, L. C., & Valenca, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 336
Herrera-Campos, A. B., Zamudio-Martinez, E., Delgado-Bellido, D., Fernández-Cortés, M., Montuenga, L. M., Oliver, F. J., & Garcia-Diaz, A. (2022) · Cancers · doi:10.3390/cancers14112740 · Cited by 17
Metadata
- Authors
- Singer, M., Young, P. J., Laffey, J. G., Asfar, P., Taccone, F. S., Skrifvars, M. B., Meyhoff, C. S., & Radermacher, P.
- Venue
- Critical Care
- Published
- 2021-12-19
- Volume
- 25
- Issue
- 1
- Pages
- 440-440
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W4200543832
- Cited by
- 282
- References
- 137
- FWCI
- 26.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Singer, M., Young, P. J., Laffey, J. G., Asfar, P., Taccone, F. S., Skrifvars, M. B., Meyhoff, C. S., & Radermacher, P. (2021). Dangers of hyperoxia. Critical Care. https://doi.org/10.1186/s13054-021-03815-y
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
