Evidence for the Specificity of Intracortical Inhibitory Dysfunction in Asymptomatic Concussed Athletes
Abstract
Sports concussions affect thousands of individuals every year and are a major public health concern. Still, little is known about the long-term and cumulative effects of concussions on brain neurophysiology. The principal objective of this study was to investigate the long-lasting effects of multiple sports concussions on sensorimotor integration and somatosensory processing in a sample of 12 concussed athletes and 14 non-concussed athletes of similar age (mean, 23 years) and education (mean, 16 years). Right median nerve stimulation was paired with transcranial magnetic stimulation (TMS) of the left primary motor cortex to investigate sensorimotor integration with short latency afferent inhibition (SAI) and long latency afferent inhibition (LAI) at five interstimulus intervals (18, 20, 22, 100, 200 msec). Somatosensory evoked potentials (SEP) were recorded from the left centro-parietal region. We also investigated primary motor cortex inhibitory mechanisms with three TMS protocols: cortical silent period, long interval intracortical inhibition, and short interval intracortical inhibition. Motor evoked potentials were recorded from the right abductor pollicis brevis muscle. No differences were observed between groups for SAI, LAI, and SEP. However, cortical silent period duration was prolonged and long interval intracortical inhibition was enhanced in the concussed group. These findings suggest that multiple sports concussions lead to specific, long-term neurophysiological dy…
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Numerous studies highlight alterations in motor cortical neurophysiology after mild traumatic brain injury (mTBI).
“Numerous studies highlight alterations in motor cortical neurophysiology after mild traumatic brain injury (mTBI).”
From Mild traumatic brain injury alters function in the dorsolateral prefrontal cortex: a TMS-EEG study (2025) · cites this paper as Tremblay et al. 2011
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- Authors
- Tremblay, S., de Beaumont, L., Lassonde, M., & Théoret, H.
- Affiliations
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- McGill University, Montreal, Quebec, Canada.
- Corresponding author
- Théoret, Hugo
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2011-04
- Volume
- 28
- Issue
- 4
- Pages
- 493-502
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2157467604
- Cited by
- 86
- References
- 77
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 3
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- sports-related concussion, multiple concussions, intracortical inhibition, primary motor cortex, cortical silent period, long-interval intracortical inhibition, short-interval intracortical inhibition, short-latency afferent inhibition, sensorimotor integration, somatosensory processing, GABAB receptors, asymptomatic athletes
- MeSH terms
- Adult, Analysis of Variance, Athletic Injuries, Brain Concussion, Electric Stimulation, Evoked Potentials, Somatosensory, Humans, Male, Median Nerve, Motor Cortex, Neural Conduction, Neural Inhibition, Transcranial Magnetic Stimulation, Athletes
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