CoChat
Sign Up
Cited by 24

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

The Dual Cyclooxygenase/5-Lipoxygenase Inhibitor Licofelone Attenuates P-Glycoprotein-Mediated Drug Resistance in the Injured Spinal Cord

Dulin, Jennifer N., Moore, Meredith L., Grill, Raymond J.·2013·Journal of Neurotrauma
DOI 10.1089/neu.2012.2587
Open this paper in CoChat — free account

Abstract

There are currently no proven effective treatments that can improve recovery of function in spinal cord injury (SCI) patients. Many therapeutic compounds have shown promise in pre-clinical studies, but clinical trials have been largely unsuccessful. P-glycoprotein (Pgp, Abcb1b) is a drug efflux transporter of the blood-spinal cord barrier that limits spinal cord penetration of blood-borne xenobiotics. Pathological Pgp upregulation in diseases such as cancer causes heightened resistance to a broad variety of therapeutic drugs. Importantly, several drugs that have been evaluated for the treatment of SCI, such as riluzole, are known substrates of Pgp. We therefore examined whether Pgp-mediated pharmacoresistance diminishes delivery of riluzole to the injured spinal cord. Following moderate contusion injury at T10 in male Sprague-Dawley rats, we observed a progressive, spatial spread of increased Pgp expression from 3 days to 10 months post-SCI. Spinal cord uptake of i.p.-delivered riluzole was significantly reduced following SCI in wild type but not Abcb1a-knockout rats, highlighting a critical role for Pgp in mediating drug resistance following SCI. Because inflammation can drive Pgp upregulation, we evaluated the ability of the new generation dual anti-inflammatory drug licofelone to promote spinal cord delivery of riluzole following SCI. We found that licofelone both reduced Pgp expression and enhanced riluzole bioavailability within the lesion site at 72 h post-SCI. This wor…

Overview

Integrity signals

Registry

Crossref · 10.1089/neu.2012.2587

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 108

  1. 10.1089/neu.2009.1149 · DOI
  2. 10.1016/S0959-437X(96)80091-8 · DOI
  3. 10.2174/1567201043334650 · DOI
  4. 10.1016/j.tips.2004.06.002 · DOI · Paper page
  5. Begley D.J., 2005, Efflux Transporters and the Blood–Brain Barrier, 107
  6. 10.1056/NEJM199511233332103 · DOI
  7. Marie J.P., 1991, Blood, 78, 586, 10.1182/blood.V78.3.586.586 · DOI
  8. 10.1097/00001622-200009000-00011 · DOI
  9. 10.1016/j.neulet.2010.01.078 · DOI
  10. 10.1038/nn1676 · DOI
  11. 10.2174/138161211797440186 · DOI
  12. 10.1016/j.pscychresns.2010.05.002 · DOI
  13. 10.1016/j.tips.2005.11.009 · DOI
  14. 10.1124/mol.107.041210 · DOI
  15. 10.1016/j.pharmthera.2009.10.004 · DOI
  16. 10.1097/00006123-199905000-00052 · DOI
  17. 10.1080/10790268.1996.11719436 · DOI
  18. 10.1097/00006123-199804000-00007 · DOI
  19. Young W., 1992, J. Neurotrauma, 9, S397
  20. 10.1097/00002517-199610000-00002 · DOI
  21. 10.3171/jns.1985.63.5.0704 · DOI
  22. 10.3171/jns.1992.76.1.0023 · DOI
  23. 10.1056/NEJM199005173222001 · DOI
  24. 10.1017/S031716710000754X · DOI
  25. 10.1227/01.NEU.0000245591.16087.89 · DOI
  26. 10.3171/jns.1998.89.5.0699 · DOI
  27. 10.3171/FOC.2008.25.11.E14 · DOI
  28. 10.1021/js970163u · DOI
  29. 10.1097/00000542-200001000-00027 · DOI
  30. 10.1038/sj.sc.3101891 · DOI
  31. 10.1111/j.1471-4159.2006.03799.x · DOI
  32. 10.1089/089771503770195867 · DOI
  33. 10.1523/JNEUROSCI.5275-03.2004 · DOI
  34. 10.1523/JNEUROSCI.1661-07.2007 · DOI
  35. 10.1016/j.ejpain.2008.08.001 · DOI
  36. Milane A., 2007, J. Neurochem., 103, 164, 10.1111/j.1471-4159.2007.04772.x · DOI
  37. 10.1097/00007632-199510001-00002 · DOI
  38. 10.3171/spi.2001.94.2.0245 · DOI
  39. 10.1016/S0079-6123(02)37016-X · DOI
  40. 10.1016/j.neuroscience.2004.01.019 · DOI
  41. 10.1089/neu.2010.1539 · DOI
  42. 10.1016/j.neulet.2009.03.016 · DOI
  43. 10.3171/jns.1989.71.3.0403 · DOI
  44. 10.1016/S0750-7658(98)80058-0 · DOI
  45. 10.1038/sj.sc.3100962 · DOI
  46. Zhang L., 2003, Acta Pharmacol. Sin., 24, 903
  47. 10.2165/00023210-200822060-00002 · DOI
  48. Wiffen P.J., 2011, Cochrane Database Syst. Rev., 2, CD006044
  49. 10.1016/j.neuropharm.2008.08.032 · DOI
  50. 10.1016/S0304-3940(02)00423-8 · DOI
  51. 10.1016/S0893-133X(99)00095-0 · DOI
  52. 10.1016/j.nbd.2012.03.040 · DOI
  53. 10.1007/978-1-60761-416-6_15 · DOI
  54. 10.1111/j.1528-1167.2010.02585.x · DOI
  55. Liu B., 2009, Cell Biol. Int., 34, 21, 10.1042/CBI20090129 · DOI
  56. Szczuraszek K., 2009, Oncol. Rep., 22, 1315
  57. 10.1002/jcb.22239 · DOI
  58. 10.1016/j.canlet.2011.01.025 · DOI
  59. 10.1007/s11095-008-9596-1 · DOI
  60. 10.1002/jnr.21508 · DOI
  61. 10.1089/neu.1998.15.1005 · DOI
  62. 10.1007/1-4020-5688-5_1 · DOI
  63. 10.1146/annurev.biochem.69.1.145 · DOI · Paper page
  64. Fiorucci S., 2001, Pharmacol., 62, 1433
  65. 10.1200/JCO.2005.14.209 · DOI
  66. 10.1158/1078-0432.CCR-04-0945 · DOI
  67. Mao J.T., 2003, Clin. Cancer Res., 9, 5835
  68. 10.1016/j.bbagen.2011.02.005 · DOI
  69. 10.1111/j.1398-9995.1997.tb01039.x · DOI
  70. 10.1093/carcin/bgi012 · DOI
  71. 10.1093/rheumatology/keh105 · DOI
  72. 10.2147/ciia.2007.2.1.73 · DOI
  73. 10.1007/978-1-60327-389-3_15 · DOI
  74. 10.1089/neu.2009.0997 · DOI
  75. 10.1371/journal.pone.0016456 · DOI
  76. 10.1089/08977150360547099 · DOI
  77. 10.1089/neu.1995.12.1 · DOI · Paper page
  78. 10.1016/j.jchromb.2004.11.053 · DOI
  79. 10.1016/j.jchromb.2004.01.004 · DOI
  80. Beggs J.L., 1976, Lab. Invest., 34, 428
  81. 10.1002/(SICI)1096-9861(19961223)376:4<542::AID-CNE4>3.0.CO;2-1 · DOI
  82. Sinescu C., 2010, J. Med. Life, 3, 254
  83. 10.1073/pnas.86.2.695 · DOI
  84. 10.1016/j.neuropharm.2009.09.012 · DOI
  85. 10.2174/138920111795164020 · DOI
  86. 10.1212/WNL.47.6_Suppl_4.233S · DOI
  87. 10.1016/S0304-3940(01)01904-8 · DOI
  88. 10.1006/exnr.2001.7702 · DOI
  89. 10.1385/JMN:21:2:173 · DOI
  90. 10.1124/mol.111.074179 · DOI
  91. 10.1124/jpet.109.152520 · DOI
  92. 10.1097/00008571-200210000-00004 · DOI · Paper page
  93. 10.1097/00008571-200210000-00005 · DOI
  94. 10.1093/jnen/63.10.1038 · DOI
  95. 10.1007/s00702-008-0030-y · DOI
  96. Wijnholds J., 2005, Efflux Transporters and the Blood–Brain Barrier, 137
  97. 10.1111/j.1528-1167.2006.00939.x · DOI
  98. 10.2174/1381612043384844 · DOI
  99. 10.1111/j.1471-4159.2007.05099.x · DOI
  100. 10.1002/nbm.1343 · DOI · Paper page
  101. 10.1089/neu.2008.0860 · DOI
  102. 10.18433/J36C78 · DOI
  103. 10.2165/00003088-198917020-00004 · DOI
  104. 10.2174/138920009788498996 · DOI
  105. 10.1111/j.1471-4159.2006.03993.x · DOI
  106. 10.1111/j.1572-0241.2004.04133.x · DOI
  107. 10.1016/j.jneuroim.2005.05.009 · DOI
  108. 10.1038/sj.bjp.0707577 · DOI

Cited by

Sorted by citations

See all 24

Metadata

Authors
Dulin, J. N., Moore, M. L., & Grill, R. J.
Affiliations
  • Department of Integrative Biology and Pharmacology, The University of Texas Medical School at Houston, Houston, Texas.
  • Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, Texas.
Venue
Journal of Neurotrauma
Publisher
SAGE Publications
Published
2013-02
Volume
30
Issue
3
Pages
211-226
ISSN
  • 0897-7151
  • 1557-9042
DOI
10.1089/neu.2012.2587
Cited by
24
References
4
Language
en
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review