Efficacy and Safety of Enzyme-Modified Panax ginseng for Anti-Wrinkle Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study
Abstract
Human skin undergoes changes during aging that result from the synergistic effects of intrinsic and extrinsic factors that may culminate in wrinkle formation, a characteristic of aged skin. Panax ginseng and ginsenosides have promising properties in preventing skin aging. Our previous study demonstrated that enzyme-modified ginseng extract (EG) has inhibitory effects against ultraviolet B (UVB) radiation-induced skin aging. The purpose of the current study was to evaluate the preventive effects of EG on eye-wrinkle formation by applying EG cream in 23 randomized human subjects. Compared to the placebo, EG significantly reduced the global photo-damage score. In addition, total roughness (R1), smoothness depth (R4), and arithmetic roughness average (R5) were significantly decreased with use of EG. In a post-study questionnaire, subjects responded that EG was absorbed efficiently into the skin and was more potent in moisturizing and softening skin than the placebo. No participants reported adverse reactions to treatment. In conclusion, EG sufficiently suppressed eye wrinkle formation by decreasing various roughness measures on the basis of assessment with non-invasive devices. Therefore, our results indicate that EG is a promising anti-aging candidate that could be used as an ingredient in natural functional food and cosmetic products.
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The Hwang et al. 31 study is considered Level 2b evidence according to the Oxford Centre for Evidence-Based Medicine.
“The study is a single‐center, randomized, double‐blind, placebo‐controlled trial, which is considered Level 2b evidence according to the Oxford Centre for Evidence‐Based Medicine.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [31]
Enzyme-modified Panax ginseng showed a significant improvement in wrinkle depth and overall skin appearance compared to placebo.
“The study found that the group receiving the enzyme‐modified Panax ginseng showed a significant improvement in wrinkle depth and overall skin appearance compared to the placebo group.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [31]
The Hwang et al. 31 study had a small sample size of only 40 participants.
“First, the sample size of the study is small, with only 40 participants included.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [31]
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Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
- Authors
- Hwang, E., Park, S.-Y., Jo, H., Lee, D.-G., Kim, H.-T., Kim, Y. M., Yin, C. S., & Yi, T. H.
- Affiliations
- Kyung Hee University (KR)
- Semyung University (KR)
- Corresponding author
- Yi, Tae Hoo
- Venue
- Rejuvenation Research
- Publisher
- SAGE Publications
- Published
- 2015-10
- Volume
- 18
- Issue
- 5
- Pages
- 449-457
- ISSN
- 1094-5458 (ISSN-L)
- 1549-1684
- 1557-8577
- OpenAlex
- W1705315052
- Cited by
- 20
- References
- 24
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Rejuvenation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- Panax ginseng, ginsenosides, skin aging, anti-aging cosmetics, skin roughness, photodamage, topical cream, skin hydration, skin softening
- MeSH terms
- Adult, Aged, Demography, Double-Blind Method, Female, Panax, Humans, Middle Aged, Plant Extracts, Surveys and Questionnaires, Skin, Skin Aging, Treatment Outcome, Patient Satisfaction
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