The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Immunogenicity of Adult Mesenchymal Stem Cells: Lessons from the Fetal Allograft
Abstract
Herein we review recent data that support host tolerance of allogeneic adult mesenchymal stem cells (MSC). Evidence is emerging that donor MSC deploy a very powerful array of mechanisms that allow escape from host allogeneic responses. These mechanisms include limited expression of alloantigen by the stem cell and cell contact-dependent and -independent mechanisms. MSC modulate host dendritic cell and T cell function, promoting induction of suppressor or regulatory T cells. These effects are complemented by the induction of divisional arrest anergy in T cells and by stem cell production of soluble immunomodulatory factors, including interleukin-10, transforming growth factor-beta, prostaglandin E2, and hepatocyte growth factor. In addition, MSC express the enzyme indoleamine 2,3-dioxygenase, which creates a tryptophan-depleted milieu that promotes immunosuppression. We propose that these observations show striking similarity to emerging data on the maternal acceptance of the fetal allograft. This comparison suggests new approaches to determine the contribution of different mechanisms to the successful use of MSC in regenerative medicine.
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Cites
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341
Nanotubular Highways for Intercellular Organelle Transport
Rustom, A., Saffrich, R., Markovic, I., Walther, P., & Gerdes, H.-H. (2004) · Science · doi:10.1126/science.1093133 · Cited by 2,038
Munn, D. H., Sharma, M. D., Hou, D., Baban, B., Lee, J. R., Antonia, S. J., Messina, J. L., Chandler, P., Koni, P. A., & Mellor, A. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21583 · Cited by 852
Cited by
Mesenchymal stem cells avoid allogeneic rejection
Ryan, J. M., Barry, F. P., Murphy, J. M., & Mahon, B. P. (2005) · Journal of Inflammation · doi:10.1186/1476-9255-2-8 · Cited by 714
Self-citationGonzález, M. A., Gonzalez–Rey, E., Rico, L., Büscher, D., & Delgado, M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.11.041 · Cited by 631
González, M. A., Gonzalez‐Rey, E., Rico, L., Büscher, D., & Delgado, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24405 · Cited by 489
Stroke-Induced Immunodepression: Experimental Evidence and Clinical Relevance
Dirnagl, U., Klehmet, J., Braun, J. S., Harms, H., Meisel, C., Ziemssen, T., Prass, K., & Meisel, A. (2007) · Stroke · doi:10.1161/01.str.0000251441.89665.bc · Cited by 473
Immune modulation by mesenchymal stem cells
Rasmusson, I. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.019 · Cited by 374
Metadata
- Authors
- Barry, F. P., Murphy, J. M., English, K., & Mahon, B. P.
- Venue
- Stem Cells and Development
- Publisher
- SAGE Publications
- Published
- 2005-06
- Volume
- 14
- Issue
- 3
- Pages
- 252-265
- ISSN
- 1525-8165 (ISSN-L)
- 1547-3287
- 1557-8534
- OpenAlex
- W2082711170
- Cited by
- 201
- References
- 5
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
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