The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Platelet-Rich Fibrin is a Bioscaffold and Reservoir of Growth Factors for Tissue Regeneration
Abstract
The platelet-rich fibrin (PRF) is known as a rich source of autologous cytokines and growth factors and universally used for tissue regeneration in current clinical medicine. However, the microstructure of PRF has not been fully investigated nor have been studied the key molecules that differ PRF from platelet-rich plasma. We fabricated PRF under Choukroun's protocol and produced its extract (PRFe) by freezing at -80°C. The conventional histological, immunohistological staining, and scanning electron microscopy images showed the microstructure of PRF, appearing as two zones, the zone of platelets and the zone of fibrin, which resembled a mesh containing blood cells. The PRFe increased proliferation, migration, and promoted differentiation of the human alveolar bone marrow stem cells (hABMSCs) at 0.5% concentration in vitro. From the results of proteome array, matrix metalloproteinase 9 (MMP9) and Serpin E1 were detected especially in PRFe but not in concentrated platelet-rich plasma. Simultaneous elevation of MMP9, CD44, and transforming growth factor β-1 receptor was shown at 0.5% PRFe treatment to the hABMSC in immunoblot. Mineralization assay showed that MMP9 directly regulated mineralization differentiation of hABMSC. Transplantation of the fresh PRF into the mouse calvarias enhanced regeneration of the critical-sized defect. Our results strongly support the new characteristics of PRF as a bioscaffold and reservoir of growth factors for tissue regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Marx, R. E., Carlson, E. R., Eichstaedt, R. M., Schimmele, S. R., Strauss, J. E., & Georgeff, K. R. (1998) · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · doi:10.1016/s1079-2104(98)90029-4 · Cited by 2,598
Dohan Ehrenfest, D. M., Rasmusson, L., & Albrektsson, T. (2009) · Trends in Biotechnology · doi:10.1016/j.tibtech.2008.11.009 · Cited by 2,008
Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Gogly, B. (2006) · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · doi:10.1016/j.tripleo.2005.07.008 · Cited by 1,861
Choukroun, J., Diss, A., Simonpieri, A., Girard, M.-O., Schoeffler, C., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Dohan, D. (2006) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2005.07.011 · Cited by 1,328
Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Gogly, B. (2006) · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · doi:10.1016/j.tripleo.2005.07.009 · Cited by 1,191
Adipose-derived adult stromal cells heal critical-size mouse calvarial defects
Cowan, C. M., Shi, Y.-Y., Aalami, O. O., Chou, Y.-F., Mari, C., Thomas, R., Quarto, N., Contag, C. H., Wu, B., & Longaker, M. T. (2004) · Nature Biotechnology · doi:10.1038/nbt958 · Cited by 914
Whitman, D. H., Berry, R. L., & Green, D. M. (1997) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0278-2391(97)90187-7 · Cited by 817
Thrombin generation and fibrin clot structure
Wolberg, A. S. (2007) · Blood Reviews · doi:10.1016/j.blre.2006.11.001 · Cited by 747
Choukroun, J., Diss, A., Simonpieri, A., Girard, M.-O., Schoeffler, C., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Dohan, D. M. (2006) · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · doi:10.1016/j.tripleo.2005.07.012 · Cited by 734
Yu, Q., & Stamenkovic, I. (1999) · Genes & Development · doi:10.1101/gad.13.1.35 · Cited by 713
Cited by
Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H., Nakata, K., Uematsu, K., Su, C.-Y., & Kawase, T. (2016) · International Journal of Implant Dentistry · doi:10.1186/s40729-016-0052-4 · Cited by 459
Zhou, Y., Liu, X., She, H., Wang, R., Bai, F., & Xiang, B. (2022) · Regenerative Therapy · doi:10.1016/j.reth.2022.08.006 · Cited by 49
Metadata
- Authors
- Kang, Y.-H., Jeon, S. H., Park, J.-Y., Chung, J.-H., Choung, Y.-H., Choung, H.-W., Kim, E.-S., & Choung, P.-H.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2011-02
- Volume
- 17
- Issue
- 3-4
- Pages
- 349-359
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- OpenAlex
- W1992667806
- Cited by
- 254
- References
- 31
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Platelet-Rich Fibrin is a Bioscaffold and Reservoir of Growth Factors for Tissue Regeneration. https://app.cochat.ai/papers/10.1089/ten.tea.2010.0327
- The paper
- Kang, Y.-H., Jeon, S. H., Park, J.-Y., Chung, J.-H., Choung, Y.-H., Choung, H.-W., Kim, E.-S., & Choung, P.-H. (2011). Platelet-Rich Fibrin is a Bioscaffold and Reservoir of Growth Factors for Tissue Regeneration. Tissue Engineering Part A. https://doi.org/10.1089/ten.tea.2010.0327
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
