The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF)
Open accessAbstract
BACKGROUND: The development of platelet-rich fibrin (PRF) drastically simplified the preparation procedure of platelet-concentrated biomaterials, such as platelet-rich plasma (PRP), and facilitated their clinical application. PRF's clinical effectiveness has often been demonstrated in pre-clinical and clinical studies; however, it is still controversial whether growth factors are significantly concentrated in PRF preparations to facilitate wound healing and tissue regeneration. To address this matter, we performed a comparative study of growth factor contents in PRP and its derivatives, such as advanced PRF (A-PRF) and concentrated growth factors (CGF). METHODS: PRP and its derivatives were prepared from the same peripheral blood samples collected from healthy donors. A-PRF and CGF preparations were homogenized and centrifuged to produce extracts. Platelet and white blood cell counts in A-PRF and CGF preparations were determined by subtracting those counts in red blood cell fractions, supernatant acellular serum fractions, and A-PRF/CGF exudate fractions from those counts of whole blood samples. Concentrations of growth factors (TGF-β1, PDGF-BB, VEGF) and pro-inflammatory cytokines (IL-1β, IL-6) were determined using ELISA kits. RESULTS: Compared to PRP preparations, both A-PRF and CGF extracts contained compatible or higher levels of platelets and platelet-derived growth factors. In a cell proliferation assay, both A-PRF and CGF extracts significantly stimulated the proliferation of human periosteal cells without significant reduction at higher doses. CONCLUSIONS: These data clearly demonstrate that both A-PRF and CGF preparations contain significant amounts of growth factors capable of stimulating periosteal cell proliferation, suggesting that A-PRF and CGF preparations function not only as a scaffolding material but also as a reservoir to deliver certain growth factors at the site of application.
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Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Gogly, B. (2006) · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · doi:10.1016/j.tripleo.2005.07.008 · Cited by 1,861
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Self-citationPlatelet-Rich Fibrin is a Bioscaffold and Reservoir of Growth Factors for Tissue Regeneration
Kang, Y.-H., Jeon, S. H., Park, J.-Y., Chung, J.-H., Choung, Y.-H., Choung, H.-W., Kim, E.-S., & Choung, P.-H. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0327 · Cited by 254
Platelet-rich Plasma and Platelet-rich fibrin in human cell culture
Gaßling, V. L. W., Açil, Y., Springer, I. N., Hubert, N., & Wiltfang, J. (2009) · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · doi:10.1016/j.tripleo.2009.02.007 · Cited by 185
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Self-citationPlatelet‐rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation
Roy, S., Driggs, J., Elgharably, H., Biswas, S., Findley, M., Khanna, S., Gnyawali, U. S., Bergdall, V. K., & Sen, C. K. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2011.00740.x · Cited by 174
Bioactivity and stability of endogenous fibrogenic factors in platelet‐rich fibrin
Lundquist, R., Dziegiel, M. H., & Ågren, M. S. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00344.x · Cited by 173
The use of plasma-rich growth factors (PRGF) in oral surgery.
Anitua, E. (2001) · PubMed · Cited by 162
A recently developed bifacial platelet-rich fibrin matrix
Lucarelli, E., Beretta, R., Dozza, B., Tazzari, P. L., O’Connell, S., Ricci, F., Pierini, M., Squarzoni, S., Pagliaro, P. P., Oprita, E., et al. (2010) · European Cells and Materials · doi:10.22203/ecm.v020a02 · Cited by 131
Zumstein, M. A., Berger, S., Schober, M., Boileau, P., Nyffeler, R. W., Horn, M., & Dahinden, C. A. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112800624337 · Cited by 115
Cited by
Zhou, Y., Liu, X., She, H., Wang, R., Bai, F., & Xiang, B. (2022) · Regenerative Therapy · doi:10.1016/j.reth.2022.08.006 · Cited by 49
Metadata
- Authors
- Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H., Nakata, K., Uematsu, K., Su, C.-Y., & Kawase, T.
- Venue
- International Journal of Implant Dentistry
- Published
- 2016-08-22
- Volume
- 2
- Issue
- 1
- Pages
- 19-19
- ISSN
- 2198-4034 (ISSN-L)
- OpenAlex
- W2511643530
- Cited by
- 459
- References
- 13
- FWCI
- 33.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). https://app.cochat.ai/papers/10.1186/s40729-016-0052-4
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- Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H., Nakata, K., Uematsu, K., Su, C.-Y., & Kawase, T. (2016). Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). International Journal of Implant Dentistry. https://doi.org/10.1186/s40729-016-0052-4
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