The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds
Open accessAbstract
The extracellular matrix (ECM) plays important roles in influencing cellular behavior such as attachment, differentiation, and proliferation. However, in conventional culture and tissue engineering strategies, single proteins are frequently utilized, which do not mimic the complex extracellular microenvironment seen in vivo. In this study we report a method to decellularize brain tissue using detergents. This decellularized brain matrix is rich in glycosaminoglycans and contains collagen I, collagen III, collagen IV, collagen V, collagen VI, perlecan, and laminin. By further processing the material into a liquid form, the brain matrix can be used as a cell culture coating. Neurons derived from human induced pluripotent stem cells plated on the brain matrix express neuronal markers and assume neuronal morphology. Additionally, the same material can potentially be used as a scaffold for tissue engineering as it reassembles upon injection in vivo to form a gel. Thus, our work demonstrates the ability to use decellularized brain ECM for cell culture and tissue engineering applications.
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Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Decellularization of tissues and organs
Gilbert, T. W., Sellaro, T. L., & Badylak, S. F. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.014 · Cited by 2,222
Ruoslahti, E. (1996) · Glycobiology · doi:10.1093/glycob/6.5.489 · Cited by 467 · cited 1×
“14,15 Recently, several groups attempted to recapitulate the physical, chemical, and biological properties of brain tissue in culture by using hydrogels of hyaluronic acid, collagen, and laminin to provide proteins and GAGs for neural stem cell growth 16 or by studying neural cell response to…”
Venstrom, K. A., & Reichardt, L. F. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.11.8370483 · Cited by 269
Cited by
Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680
A hydrogel derived from decellularized dermal extracellular matrix
Wolf, M. T., Daly, K. A., Brennan-Pierce, E. P., Johnson, S. A., Carruthers, C. A., D'Amore, A., Nagarkar, S. P., Velankar, S. S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.051 · Cited by 482
Extracellular matrix hydrogel therapies: In vivo applications and development
Spang, M. T., & Christman, K. L. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.12.019 · Cited by 304
Self-citationMulti-lineage human iPSC-derived platforms for disease modeling and drug discovery
Sharma, A., Sances, S., Workman, M. J., & Svendsen, C. N. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.02.011 · Cited by 296
Regenerative Therapies for Central Nervous System Diseases: a Biomaterials Approach
Tam, R. Y., Fuehrmann, T., Mitrousis, N., & Shoichet, M. S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.237 · Cited by 293
Metadata
- Authors
- DeQuach, J. A., Yuan, S. H., Goldstein, L. S. B., & Christman, K. L.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2011-11
- Volume
- 17
- Issue
- 21-22
- Pages
- 2583-2592
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- OpenAlex
- W2146646647
- Cited by
- 234
- References
- 4
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- green
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- DeQuach, J. A., Yuan, S. H., Goldstein, L. S. B., & Christman, K. L. (2011). Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds. Tissue Engineering Part A. https://doi.org/10.1089/ten.tea.2010.0724
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