Peripheral Nerve Repair in Rats Using Composite Hydrogel-Filled Aligned Nanofiber Conduits with Incorporated Nerve Growth Factor

FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy

Kehoe, S., Zhang, X. F., & Boyd, D. (2011) · Injury · doi:10.1016/j.injury.2010.12.030 · Cited by 726 · see citing works

Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-ε-caprolactone and a collagen/poly-ε-caprolactone blend

Schnell, E., Klinkhammer, K., Balzer, S., Brook, G. A., Klee, D., Dalton, P. D., & Mey, J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.03.009 · Cited by 726 · see citing works

Peripheral Nerve Injury and Repair

Lee, S. K., & Wolfe, S. W. (2000) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200007000-00005 · Cited by 685 · see citing works

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

Attal, N., Jazat, F., Kayser, V., & Guilbaud, G. (1990) · Pain · doi:10.1016/0304-3959(90)90022-6 · Cited by 503 · see citing works

Current applications and future perspectives of artificial nerve conduits

Jiang, X., Lim, S. H., Mao, H., & Chew, S. Y. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.009 · Cited by 394 · see citing works

Bioactive Nanofibers: Synergistic Effects of Nanotopography and Chemical Signaling on Cell Guidance

Patel, S. A., Kurpinski, K. T., Quigley, R., Gao, H., Hsiao, B. S., Poo, M., & Li, S. (2007) · Nano Letters · doi:10.1021/nl071182z · Cited by 362 · see citing works

US Food and Drug Administration/Conformit Europe-Approved Absorbable Nerve Conduits for Clinical Repair of Peripheral and Cranial Nerves

Meek, M. F., & Coert, J. H. (2008) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e31804d441c · Cited by 271 · see citing works

Limitations of Conduits in Peripheral Nerve Repairs

Moore, A. M., Kasukurthi, R., Magill, C. K., Farhadi, H. F., Borschel, G. H., & Mackinnon, S. E. (2009) · Hand · doi:10.1007/s11552-008-9158-3 · Cited by 268 · see citing works

Nerve fiber growth in culture on fibronectin, collagen, and glycosaminoglycan substrates

Carbonetto, S., Gruver, M. M., & Turner, D. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-11-02324.1983 · Cited by 264 · see citing works

Outcome measures of peripheral nerve regeneration

Wood, M. D., Kemp, S. W. P., Weber, C., Borschel, G. H., & Gordon, T. (2011) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2011.04.008 · Cited by 264 · see citing works

Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps

Dodla, M. C., & Bellamkonda, R. V. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.08.045 · Cited by 254 · see citing works

A systematic review of animal models used to study nerve regeneration in tissue-engineered scaffolds

Angius, D., Wang, H., Spinner, R. J., Gutierrez-Cotto, Y., Yaszemski, M. J., & Windebank, A. J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.07.056 · Cited by 228 · see citing works

Nerve growth factor enhances regeneration through silicone chambers

Rich, K. M., Alexander, T. D., Pryor, J. C., & Hollowell, J. P. (1989) · Experimental Neurology · doi:10.1016/0014-4886(89)90115-5 · Cited by 216 · see citing works

Cell-Laden Hydrogel Constructs of Hyaluronic Acid, Collagen, and Laminin for Neural Tissue Engineering

Suri, S., & Schmidt, C. E. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0381 · Cited by 214 · see citing works

Photopatterned collagen–hyaluronic acid interpenetrating polymer network hydrogels

Suri, S., & Schmidt, C. E. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.05.004 · Cited by 209 · see citing works

Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration

Madduri, S., Papaloïzos, M., & Gander, B. A. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.073 · Cited by 196 · see citing works

In Vitro Assessment of Axonal Growth Using Dorsal Root Ganglia Explants in a Novel Three-Dimensional Collagen Matrix

Bozkurt, A., Brook, G. A., Moellers, S., et al. (2007) · Tissue Engineering · doi:10.1089/ten.2007.0116 · Cited by 191 · see citing works

Treatment of Acute Peripheral Nerve Injuries: Current Concepts

Isaacs, J. E. (2010) · The Journal Of Hand Surgery · doi:10.1016/j.jhsa.2009.12.009 · Cited by 146 · see citing works

Neurotrophin releasing single and multiple lumen nerve conduits

Yang, Y., Laporte, L. D., Rives, C. B., Jang, J., Lin, W., Shull, K. R., & Shea, L. D. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.02.022 · Cited by 137 · see citing works

Dose and duration of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve injury in the rat

Kemp, S. W. P., Webb, A. A., Dhaliwal, S., Syed, S., Walsh, S. K., & Midha, R. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.03.017 · Cited by 129 · see citing works

Early peripheral nerve healing in collagen and silicone tube implants: Myofibroblasts and the cellular response

Chamberlain, L. J., Yannas, I. V., Arrizabalaga, A., et al. (1998) · Biomaterials · doi:10.1016/s0142-9612(98)00018-0 · Cited by 128 · see citing works

Nerve Fiber Growth on Defined Hydrogel Substrates

Carbonetto, S., Gruver, M. M., & Turner, D. (1982) · Science · doi:10.1126/science.7079743 · Cited by 126 · see citing works

In vivostudy of novel nanofibrous intra-luminal guidance channels to promote nerve regeneration

Koh, H. S., Yong, T., Teo, W. E., Chan, C. K., Puhaindran, M. E., Tan, T. C., Lim, A., Lim, B.-H., & Ramakrishna, S. (2010) · Journal of Neural Engineering · doi:10.1088/1741-2560/7/4/046003 · Cited by 119 · see citing works

Injectable intrathecal delivery system for localized administration of EGF and FGF-2 to the injured rat spinal cord

Hamann, M. C. J., Tator, C. H., & Shoichet, M. S. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.01.030 · Cited by 116 · see citing works

Return of Motor Function After Segmental Nerve Loss in a Rat Model: Comparison of Autogenous Nerve Graft, Collagen Conduit, and Processed Allograft (AxoGen)

Giusti, G., Willems, W. F., Kremer, T. L., et al. (2012) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.k.00253 · Cited by 114 · see citing works

Effects of hyaluronic acid on peripheral nerve scarring and regeneration in rats

Özgenel, G. Y. (2003) · Microsurgery · doi:10.1002/micr.10209 · Cited by 110 · see citing works

Hyaluronic acid enhances peripheral nerve regeneration in vivo

Wang, K., Nemeth, I. R., Seckel, B. R., Chakalis-Haley, D. P., Swann, D. A., Kuo, J.-W., Bryan, D. J., & Cetrulo, C. L. (1998) · Microsurgery · doi:10.1002/(sici)1098-2752(1998)18:4 · Cited by 102 · see citing works

Hyaluronic-acid-based semi-interpenetrating materials

Xin, X., Borzacchiello, A., Netti, P. A., Ambrosio, L., & Nicolais, L. (2004) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/1568562041753025 · Cited by 101 · see citing works

Engineering Bi-Layer Nanofibrous Conduits for Peripheral Nerve Regeneration

Zhu, Y., Wang, A., Patel, S. A., et al. (2011) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2010.0565 · Cited by 98 · see citing works

Peripheral nerve regeneration through a synthetic hydrogel nerve tube

Belkas, J. S., Munro, C. A., Shoichet, M. S., et al. (2005) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2005-00286 · Cited by 91 · see citing works

Effects of collagen 1, fibronectin, laminin and hyaluronic acid concentration in multi-component gels on neurite extension

Deister, C. A., Aljabari, S., & Schmidt, C. E. (2007) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856207781494377 · Cited by 89 · see citing works

Electrical Stimulation Accelerates Motor Functional Recovery in the Rat Model of 15-mm Sciatic Nerve Gap Bridged by Scaffolds With Longitudinally Oriented Microchannels

Huang, J., Lü, L., Hu, X., Ye, Z., Peng, Y., Yan, X., Geng, D., & Luo, Z. (2010) · Neurorehabilitation and neural repair · doi:10.1177/1545968310368686 · Cited by 86 · see citing works

Nanofibrous nerve conduit-enhanced peripheral nerve regeneration

Jiang, X., Mi, R., Höke, A., & Chew, S. Y. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1531 · Cited by 83 · see citing works

Effects of Nerve Growth Factor on Nerve Regeneration through a Vein Graft across a Gap

Pu, L. L. Q., Syed, S. A., Reid, M., et al. (1999) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199910000-00021 · Cited by 77 · see citing works

Effect of Surface Pore Structure of Nerve Guide Conduit on Peripheral Nerve Regeneration

Oh, S. H., Kim, J. R., Kwon, G. B., et al. (2012) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2012.0221 · Cited by 75 · see citing works

Differential action of morphine and various opioid agonists on thermal allodynia and hyperalgesia in mononeuropathic rats

Lee, S., Kayser, V., Desmeules, J. A., & Guilbaud, G. (1994) · Pain · doi:10.1016/0304-3959(94)90228-3 · Cited by 72 · see citing works

In vitro comparison of motor and sensory neuron outgrowth in a 3D collagen matrix

Allodi, I., Guzmán-Lenis, M.-S., Hernández, J., et al. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.03.006 · Cited by 68 · see citing works

Keratin Gel Filler for Peripheral Nerve Repair in a Rodent Sciatic Nerve Injury Model

Lin, Y.-C., Ramadan, M., Dyke, M. E. V., Kokai, L. E., Philips, B. J., Rubin, J. P., & Marra, K. G. (2011) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3182268ae0 · Cited by 68 · see citing works

Novel intrathecal delivery system for treatment of spinal cord injury

Hamann, M. C. J., Tsai, E. C., Tator, C. H., & Shoichet, M. S. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00040-2 · Cited by 58 · see citing works

Salicylic acid‐derived poly(anhydride‐ester) electrospun fibers designed for regenerating the peripheral nervous system

Griffin, J., Delgado‐Rivera, R., Meiners, S. A., & Uhrich, K. E. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33049 · Cited by 56 · see citing works

Collagen gel three-dimensional matrices combined with adhesive proteins stimulate neuronal differentiation of mesenchymal stem cells

Lee, J. H., Yu, H., Lee, G., et al. (2011) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0613 · Cited by 55 · see citing works

Surface-modified nanofibrous biomaterial bridge for the enhancement and control of neurite outgrowth

Zander, N. E., Orlicki, J. A., Rawlett, A. M., et al. (2010) · Biointerphases · doi:10.1116/1.3526140 · Cited by 51 · see citing works

Ionically cross-linked chitosan microspheres for controlled release of bioactive nerve growth factor

Zeng, W., Huang, J., Hu, X., Xiao, W., Rong, M., Yuan, Z., & Luo, Z. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.10.005 · Cited by 47 · see citing works

Rat sciatic nerve repair with a poly‐lactic‐co‐glycolic acid scaffold and nerve growth factor releasing microspheres

de Boer, R., Knight, A. M., Borntraeger, A., et al. (2011) · Microsurgery · doi:10.1002/micr.20869 · Cited by 46 · see citing works

Characterization of cortical neuron outgrowth in two‐ and three‐dimensional culture systems

Lin, P., Wu, C., Chen, C.-H., et al. (2005) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30276 · Cited by 43 · see citing works

Nanofibrous scaffolds electrospun from elastomeric biodegradable poly(L-lactide-co-ε-caprolactone) copolymer

Chung, S., Moghe, A. K., Montero, G. A., Kim, S. H., & King, M. W. (2009) · Biomedical Materials · doi:10.1088/1748-6041/4/1/015019 · Cited by 40 · see citing works

Short‐ and long‐term peripheral nerve regeneration using a poly‐lactic‐co‐glycolic‐acid scaffold containing nerve growth factor and glial cell line‐derived neurotrophic factor releasing microspheres

de Boer, R., Borntraeger, A., Knight, A. M., Hébert‐Blouin, M., Spinner, R. J., Malessy, M. J. A., Yaszemski, M. J., & Windebank, A. J. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34088 · Cited by 37 · see citing works

Maintaining bioactivity of NGF for controlled release from PLGA using PEG

Johnson, P. J., Skornia, S. L., Stabenfeldt, S. E., et al. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31635 · Cited by 34 · see citing works

New artificial nerve conduits made with photocrosslinked hyaluronic acid for peripheral nerve regeneration.

Sakai, Y., Matsuyama, Y., Takahashi, K., et al. (2007) · PubMed · Cited by 32 · see citing works

Functional Motor Recovery after Peripheral Nerve Repair with an Aligned Nanofiber Tubular Conduit in a Rat Model

Jin, J., Park, M., Rengarajan, A., Zhang, Q., Limburg, S., Joshi, S. K., Patel, S. A., Kim, H. T., & Kuo, A. C. (2012) · Regenerative Medicine · doi:10.2217/rme.12.87 · Cited by 28 · see citing works

New 3D hyaluronan-based scaffold forin vitroreconstruction of the rat sciatic nerve

Zavan, B., Abatangelo, G., Mazzoleni, F., et al. (2008) · Neurological Research · doi:10.1179/174313208x281082 · Cited by 22 · see citing works

Comparing FK-506 with Basic Fibroblast Growth Factor (b-FGF) on the Repair of a Peripheral Nerve Defect Using an Autogenous Vein Bridge Model

Chaiyasate, K., Schaffner, A. D., Jackson, I. T., et al. (2009) · Journal of Investigative Surgery · doi:10.3109/08941930903410775 · Cited by 11 · see citing works

Submodality-Selective Hyperalgesia Adjacent to Partially Injured Sciatic Nerve in the Rat is Dependent on Capsaicin-Sensitive Afferent Fibers and Independent of Collateral Sprouting or a Dorsal Root Reflex

Mansikka, H. T., & Pertovaara, A. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00114-7 · Cited by 8 · see citing works

Nerve guide conduits for peripheral nerve injury repair: A review on design, materials and fabrication methods

Vijayavenkataraman, S. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.02.003 · Cited by 556 · see citing works

Application of PLCL as a biodegradable polymer in biomedical engineering

Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works

Advances in Large Gap Peripheral Nerve Injury Repair and Regeneration with Bridging Nerve Guidance Conduits

Wu, S., Shen, W., Ge, X., Ao, F., Zheng, Y., Wang, Y., Jia, X., Mao, Y., & Luo, Y. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300078 · Cited by 33 · see citing works

A novel bioactive nerve conduit for the repair of peripheral nerve injury

Yin, Y., Li, B.-B., Yan, Q., Wang, X., & Li, S. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.175062 · Cited by 16 · see citing works

End-to-side neurorrhaphy using an electrospun PCL/collagen nerve conduit for complex peripheral motor nerve regeneration

Lee, B., Ju, Y. M., Cho, J., Jackson, J. D., Lee, S. J., Atala, A., & Yoo, J. J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.008 · Cited by 101 · see citing works

Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids

Ikeguchi, R., Aoyama, T., Tanaka, M., et al. (2022) · Journal of Artificial Organs · doi:10.1007/s10047-022-01358-9 · Cited by 16 · see citing works

Keratin Gel Filler for Peripheral Nerve Repair in a Rodent Sciatic Nerve Injury Model

Lin, Y.-C., Ramadan, M., Dyke, M. E. V., Kokai, L. E., Philips, B. J., Rubin, J. P., & Marra, K. G. (2011) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3182268ae0 · Cited by 68 · see citing works