Cited by 685Nerve injury and regenerationNerve Injury and RehabilitationPeripheral Nerve Disorders

Peripheral Nerve Injury and Repair

Lee, Steve K., Wolfe, Scott W.·2000·Journal of the American Academy of Orthopaedic Surgeons

Abstract

Peripheral nerve injuries are common, and there is no easily available formula for successful treatment. Incomplete injuries are most frequent. Seddon classified nerve injuries into three categories: neurapraxia, axonotmesis, and neurotmesis. After complete axonal transection, the neuron undergoes a number of degenerative processes, followed by attempts at regeneration. A distal growth cone seeks out connections with the degenerated distal fiber. The current surgical standard is epineurial repair with nylon suture. To span gaps that primary repair cannot bridge without excessive tension, nerve-cable interfascicular auto-grafts are employed. Unfortunately, results of nerve repair to date have been no better than fair, with only 50% of patients regaining useful function. There is much ongoing research regarding pharmacologic agents, immune system modulators, enhancing factors, and entubulation chambers. Clinically applicable developments from these investigations will continue to improve the results of treatment of nerve injuries.

Integrity signals

Registry

Crossref · 10.5435/00124635-200007000-00005

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43 of 43 references verified0 citation errors · 0 not checkable

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Authors
Lee, S. K., & Wolfe, S. W.
Affiliations
  • United States Air Force (US)
  • Yale University (US)
Venue
Journal of the American Academy of Orthopaedic Surgeons
Published
2000-07
Volume
8
Issue
4
Pages
243-252
ISSN
1067-151X (ISSN-L)
OpenAlex
W2120002445
Cited by
685
References
43
Citations by year
2026: 28 · 2025: 46 · 2024: 39 · 2023: 41 · 2022: 54 · 2021: 47 · 2020: 39 · 2019: 55 · 2018: 31 · 2017: 46 · 2016: 27 · 2015: 43 · 2014: 32 · 2013: 25 · 2012: 24
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Academy of Orthopaedic Surgeons (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
Keywords
peripheral nerve injury, nerve repair, neuropraxia, axonotmesis, neurotmesis, axon transection, nerve regeneration, growth cones, nerve grafts, nerve gap bridging, immunomodulation
MeSH terms
Humans, Nerve Regeneration, Peripheral Nerves, Suture Techniques, Transplantation, Autologous, Transplantation, Homologous, Injury Severity Score, Nerve Transfer, Treatment Outcome, Recovery of Function, Peripheral Nerve Injuries

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