Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337

Foreign body reaction to biomaterials

Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138 · cited 1×

Biomaterials Science: An Introduction to Materials in Medicine

Ratner, B. D., Hoffman, A. S., Schöen, F. J., & Lemons, J. E. (1996) · doi:10.1016/c2009-0-02433-7 · Cited by 5,125

On the mechanisms of biocompatibility

Williams, D. F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.023 · Cited by 2,772

Local force and geometry sensing regulate cell functions

Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328 · cited 1×

Tissue-engineered autologous bladders for patients needing cystoplasty

Atala, A., Bauer, S. B., Söker, S., Yoo, J. J., & Retik, A. B. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68438-9 · Cited by 1,857

Evolution of the immune system in humans from infancy to old age

Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796

SARS-CoV-2 and tissue damage: current insights and biomaterial-based therapeutic strategies

Roy, H. S., Singh, R., & Ghosh, D. (2021) · Biomaterials Science · doi:10.1039/d0bm02077j · Cited by 4

Decellularized Umbilical Cord as a Scaffold to Support Healing of Full-Thickness Wounds

Kondratenko, A. A., Викторович, Т. Д., Volov, D. A., Ивановна, К. Л., Chernov, V. E., Glushakov, R. I., Sirotkina, M. Y., Zemlyanoy, D. A., Bildyug, N. B., Chebotarev, S. V., et al. (2024) · Biomimetics · doi:10.3390/biomimetics9070405 · Cited by 3

The Role and Involvement of Functional Three-Dimensional Porcine-Derived Collagen Matrix Biomaterials in Periodontal Regeneration: A Comprehensive Review

Cojocaru, C., Budală, D. G., Virvescu, D. I., Rotundu, G., Bida, F. C., Tudorici, T. A., Surlari, Z., Scurtu, M., Goriuc, A., & Luchian, I. A. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16110417 · Cited by 5

Engineering the future of organ transplantation: A comprehensive review of 3D bioprinting advances for organ bioengineering

Idnani, R., & Khan, S. (2025) · Bioprinting · doi:10.1016/j.bprint.2025.e00463 · Cited by 4

Porous silicon materials for cancer and immunotherapy

Fontana, F., Liu, Z., Hirvonen, J. J., & Santos, H. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821677-4.00020-3 · Cited by 3

Decellularized umbilical cord stroma in tissue engineering and regenerative medicine: a systematic review

Basok, Y. B., Kondratenko, A. A., Kalyuzhnaya, L. I., Volkova, E. A., Vorobyov, K., & Sevastianov, V. I. (2023) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2023-2-82-98 · Cited by 3

Phenotypical modifications of immune cells are enhanced by extracellular matrix

Teplický, T., Mateašík, A., Balázsiová, Z., Kajo, K., Vallová, M., Filová, B., Trnka, M., & Čunderlı́ková, B. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112710 · Cited by 3

Minireview: biocompatibility of engineered biomaterials, their interaction with the host cells, and evaluation of their properties

Jiménez-Rosales, A., Cortés‐Camargo, S., & Acuña-Ávila, P. E. (2022) · International Journal of Polymeric Materials · doi:10.1080/00914037.2022.2120877 · Cited by 2

Preliminary study of improving immune tolerance in vivo of bioprosthetic heart valves through a novel antigenic removal method

Song, M., Liang, Y., Tang, Z., Xie, X., Liu, Y., Qi, X., Jiang, Z., Chen, Z., Chen, C., Wu, Q., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1141247 · Cited by 2

Matrix bound nanovesicles: A great promise for TERM in less than a decade of research

Francesco, D. D., Mantovani, D., Hussey, G. S., & Boccafoschi, F. (2025) · Matrix Biology · doi:10.1016/j.matbio.2025.10.001 · Cited by 4

EFFICACY OF ACELLULAR-LYOPHILIZED HUMAN UMBILICAL CORD ECM-POWDER GUIDED BY BOVINE URINARY BLADDER MATRIX CONDUIT FOR PERIPHERAL NERVE REPAIR IN DOGS MODEL

AL-Zaidi, A. A. N., Al-Timmemi, H. A. K., & Shabeeb, Z. A. (2021) · PLANT ARCHIVES · doi:10.51470/plantarchives.2021.v21.s1.070 · Cited by 2

Tissue Engineering and Regenerative Medicine International Society Asia‐Pacific Chapter Conference 2022

Oliveira, P. F., Fragal, E. H., Sudre, G., Montembault, A., Lux, F., Tillement, O., Bonnefont-Rebeix, C., Buff, S., Udrescu, C., Chapet, O., et al. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.29036.abstracts · Cited by 2

Disorders of Localized Inflammation in Wound Healing

Nascari, D. G., Crum, R. J., & Badylak, S. F. (2020) · Springer eBooks · doi:10.1007/978-3-030-56510-7_10 · Cited by 2

Immunomodulation Strategies Using Biomaterial Chemistry and Physical Properties

Mukherjee, S. (2024) · Synthesis lectures on biomedical engineering · doi:10.1007/978-3-031-50844-8_2 · Cited by 1

The mechanism of COL4A2‐activated FAK‒PI3K‒AKT promotion of osteogenic differentiation in decellularized extracellular matrix

Zheng, Z., Fang, C., Sun, Y., Yao, M., Yang, T., Huang, J., Wang, D., & Xu, F. (2025) · Open Research (University of Surrey) · doi:10.1002/viw.20250038 · Cited by 1

Axolotl-derived decellularized skin ECM as a pro-regenerative scaffold for attenuating fibrotic wound healing

Wang, M., Kuan, C., Ma, H., & Cheng, N. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102443 · Cited by 4

Ultra-fine micronized human dermal matrix reprograms the chronic pressure-ulcer microenvironment to accelerate healing

Jin, H., Shin, B., Kim, D., Seo, Y., Lee, Y., & Lee, S.-M. (2026) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/22808000261460977 · Cited by 1

Injectable human tendon extracellular matrix via isopropanol-assisted delipidation and mild decellularization for tendon regeneration

Lee, J. K., Mun, J., Kim, H. Y., Jung, Y.-S., An, S., Kim, C., & Lee, K. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1745558 · Cited by 1

Engineering extracellular matrix-based liver hydrogels as advanced bio-mimetic platforms

Wieland, J., Weinhart, M., Papke, B., Käs, J. A., Roth, K., Sack, I., Pratschke, J., Igor, S., Hillebrandt, K. H., & Daneshgar, A. (2026) · npj gut and liver. · doi:10.1038/s44355-026-00073-z · Cited by 1

Aerosolizable Formulations of Porcine Extracellular Matrix with Antibacterial and Immunomodulatory Effects

Buendia-Otero, M., Velez-Roman, L., Jimenez-Osorio, J., Ayus-Martinez, S., Meza-Morales, W., Domenech, M., Dion, G. R., Freytes, D. O., & Mora‐Navarro, C. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01304 · Cited by 1

Nanobiomaterials in musculoskeletal regeneration

Tabatabaee, S., Najafi-Ashtiani, M., Mousavi, A., & Baheiraei, N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820262-3.00002-5 · Cited by 1

Decellularized vascular matrix material -TEVG coated with PRP for anti-degradation and anti-inflammationPreprint

Wu, Y., Xu, J., Sun, X.-H., Jiang, H., Zhou, H., Liu, Q., Cong, X., Wu, Y., & Lin, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4352075/v1 · Cited by 1

Development of tissue engineering grafts for osteochondral regeneration

Nie, X. (2018) · doi:10.32657/10220/47707

Regenerative Immunology: Pushing Biomaterials Beyond Tissue Repair

Barbosa, J. N., & Barbosa, J. N. (2020) · International Journal of Regenerative Medicine · doi:10.31487/j.rgm.2020.02.02

Utilising marine collagen as a niche structure for enhanced osteoarthritic repair

Ahmed, Z. F. (2019) · Cronfa (Swansea University) · doi:10.23889/suthesis.53521

Application of Natural Hydrogels for Cell Therapy: Focus on Osteoarthritis

Kim, C. S., & Park, S. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839163975-00393

Biomaterials and immunomodulation for spinal cord repair

Oudega, M., & Maldonado-Lasunción, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821440-4.00011-6

Mechanisms for Biomaterials Reconstruct Microenvironment in Bone Regeneration

Wei, Y., & Li, M. (2022) · Wiley eBooks · doi:10.1002/9783527837823.ch5

Regenerative Verfahren in der Mund‑, Kiefer- und Gesichtschirurgie

Smeets, R., Kämmerer, P. W., Heimes, D., Zernial, O., Ghanad, I., Fiedler, I. A. K., Fuest, S., Gosau, M., & Schäfer, S. (2023) · wissen kompakt · doi:10.1007/s11838-023-00173-z

Regenerative Surgery: Is This an Independent Field of Health Sciences or Only a Semantic Exercise?

Monetti, A. R., Savino, J. R., Miller, J., Bowlby, J. J., Byers, L. N., Rengaraj, A., Jeong, W., Peveri, E., Ruley, A. J., Asthana, A., et al. (2023) · Current Transplantation Reports · doi:10.1007/s40472-023-00409-1

A New Collector Device for the Immediate Use of Particulate Autogenous Bone Grafts

Andreucci, C. A., Fonseca, E. M. M., & Jorge, R. N. (2023) · Applied Sciences · doi:10.3390/app132011334

Editorial: Modulation of the Immune System to Improve Tissue Regeneration Strategies

Bracaglia, L. G., & Kyriakides, T. R. (2024) · Tissue Engineering Part A · doi:10.1089/ten.tea.2024.29055.editorial

Navigating the evolution of ophthalmic drug delivery and ocular regenerative medicine from conventional to cutting-edge treatments

Nezhad, N. M., Rahimi, M., Gheybi, F., Kesharwani, P., Oroojalian, F., & Sahebkar, A. (2025) · Applied Materials Today · doi:10.1016/j.apmt.2025.102602 · Cited by 1

Advancements in Biomaterials for Cartilage Tissue Engineering: Challenges and Future Directions

Jeyaraman, M., Jeyaraman, N., Ramasubramanian, S., & Nallakumarasamy, A. (2025) · Springer eBooks · doi:10.1007/978-981-96-3017-2_9

Mimicking secreted extracellular matrix-like hydrocolloid of SF/CS/CMC biological macromolecules for compounded injectable plaster-like material

Puttamawarawat, A., Sangwichien, C., Khangkhamano, M., & Meesane, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148962

Hydrogel degradation products as immunomodulatory cues in neural injury: mechanisms and implications for neural repair

Kishore, J., Boucan, F. S. O. L., Abazari, M. F., Baldo, K. A. T., Awogbindin, I. O., Akhavan, A., Tremblay, M., & Willerth, S. M. (2026) · Journal of Materials Chemistry B · doi:10.1039/d6tb00368k · Cited by 1

Peptide delivery in the management of diabetes: Exploring bioinspired nanoarchitectures using stimuli-responsive materials and supramolecular depots

Abdullahi, A. D., Ibrahim, M. A., & Serem, J. C. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127169

Bioactive Mineralized Cell-Derived Extracellular Matrix via Polymer-Induced Liquid Precursor Enhances Osteogenesis and Bone Regeneration

Kwon, J. W., Jeon, J., Yang, S. W., Chung, Y., Park, J. H., Joung, Y. K., Yang, H. S., & Park, K. (2026) · Biomaterials Research · doi:10.34133/bmr.0410

Micronized extracellular matrix particles for tissue repair: mechanisms and applications

Zhong, H., Fu, Y., Wu, X., Zhou, C., Yu, H., Yao, C., & Xiao, E. (2026) · Translational research · doi:10.1016/j.trsl.2026.08.006

3D-printed fish-skin-derived composite dECM hydrogel patch for immunomodulatory and pro-angiogenic diabetic wound repair

Lee, S. H., Moon, J. S., Noh, S., Yi, H., & Lee, H. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103753

Decellularized skin enriched with methacrylated hyaluronic acid enhances cell adhesion and accelerates wound closure

Platania, V., Tsanaktsidou, E., Kammona, O., & Chatzinikolaidou, Μ. (2026) · Biomaterials Science · doi:10.1039/d6bm01132b

Modulation of Innate Immune Response for Tissue Engineering

Kim, M. (2015) · Biosystems & biorobotics · doi:10.1007/978-3-319-21813-7_7

Immune responses to implants – a review of the implications for the design of immunomodulatory biomaterials

Franz, S., Rammelt, S., Scharnweber, D., & Simon, J. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.078 · Cited by 1,391

Immune Aspects of Scaffold Design

(2017) · Frontiers in biomaterials · doi:10.2174/9781681085364117040011

Extracellular matrix scaffold-immune microenvironment modulates tissue regeneration

Yu, Y., Zhang, W., Liu, X., Wang, H., Shen, J., Xiao, H., Mei, J., Chai, Y., & Wen, G. (2021) · Composites Part B Engineering · doi:10.1016/j.compositesb.2021.109524 · Cited by 63

Immunomodulatory biomaterials

Dziki, J. L., & Badylak, S. F. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2018.02.005 · Cited by 54