The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials
Open accessAbstract
Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.
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“As described in the previous section, ECM bioscaffolds deliver immunomodulatory signals through retained bioactive molecules and native-like architecture that influence immune cell activation, polarization, and effector function [48,80].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [80]
Citations
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Extracellular matrix-based materials for regenerative medicine
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Metadata
- Authors
- Dziki, J. L., Huleihel, L., Scarritt, M. E., & Badylak, S. F.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Badylak, Stephen F.
- ORCID
- Badylak, Stephen F.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2017-10
- Volume
- 23
- Issue
- 19-20
- Pages
- 1152-1159
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- PMC
- PMC6112165
- OpenAlex
- W2607766702
- Cited by
- 141
- References
- 94
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 14 · 2023: 17 · 2022: 21 · 2021: 28 · 2020: 10 · 2019: 10 · 2018: 13 · 2017: 6
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Tissue Engineering Part A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R21EB017184)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- immunomodulation, immune response, tissue engineering, organ transplantation
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Immunologic Factors, Immunosuppression Therapy, Organ Transplantation, Tissue Scaffolds
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