Cited by 141Tissue Engineering and Regenerative MedicineBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applications

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Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

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Dziki, Jenna L., Huleihel, Luai, Scarritt, Michelle E., Badylak, Stephen F.·2017·Tissue Engineering Part A

DOI 10.1089/ten.tea.2016.0538PMC PMC6112165

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Abstract

Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.

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Authors: Dziki, J. L., Huleihel, L., Scarritt, M. E., & Badylak, S. F.
Affiliations: University of Pittsburgh (US)
Corresponding author: Badylak, Stephen F.
ORCID: Badylak, Stephen F.
Venue: Tissue Engineering Part A
Publisher: SAGE Publications
Published: 2017-10
Volume: 23
Issue: 19-20
Pages: 1152-1159
ISSN: 1937-3341 (ISSN-L)
1937-335X
DOI: 10.1089/ten.tea.2016.0538
PMC: PMC6112165
OpenAlex: W2607766702
Cited by: 141
References: 94
Citations by year: 2026: 9 · 2025: 13 · 2024: 14 · 2023: 17 · 2022: 21 · 2021: 28 · 2020: 10 · 2019: 10 · 2018: 13 · 2017: 6
FWCI: 10.93
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Tissue Engineering Part A (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Biomedical Imaging and Bioengineering (R21EB017184)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: immunomodulation, immune response, tissue engineering, organ transplantation
MeSH terms: Animals, Biocompatible Materials, Extracellular Matrix, Humans, Immunologic Factors, Immunosuppression Therapy, Organ Transplantation, Tissue Scaffolds

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Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

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