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The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches
Abstract
Bone marrow-derived mesenchymal stem cells (MSCs) have demonstrated potential for regenerative medicine strategies. Knowledge of the way these cells respond to their environment in in vitro culture and after implantation in vivo is crucial for successful therapy. Oxygen tension plays a pivotal role in both situations. In vivo, a hypoxic environment can lead to apoptosis, but hypoxic preconditioning of MSCs and overexpression of prosurvival genes like Akt can reduce hypoxia-induced cell death. In cell culture, hypoxia can increase proliferation rates and enhance differentiation along the different mesenchymal lineages. Hypoxia also modulates the paracrine activity of MSCs, causing upregulation of various secretable factors, among which are important angiogenic factors such as vascular endothelial growth factor and interleukin-6 (IL6). Finally, hypoxia plays an important role in mobilization and homing of MSCs, primarily by its ability to induce stromal cell-derived factor-1 expression along with its receptor CXCR4. This article reviews the current literature on the effects of hypoxia on MSCs and aims to elucidate its potential role in regenerative medicine strategies.
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“hypoxia-mediated preconditioning of BM-MSCs could reduce hypoxia-induced cell death and increase BM-MSCs proliferation and differentiation [8] in vitro.”
From Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice (2014) · cites this paper as [8]
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Caplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,724
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
Toma, C., Pittenger, M. F., Cahill, K. S., Byrne, B. J., & Kessler, P. (2002) · Circulation · doi:10.1161/hc0102.101442 · Cited by 2,234
Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues.
Friedenstein, A. J., Kv, P., KUROLESOVA, A. I., & Frolova, G. P. (1968) · PubMed · Cited by 1,921
Ma, Q., Jones, D., Borghesani, P. R., Segal, R. A., Nagasawa, T., Kishimoto, T., Bronson, R. T., & Springer, T. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9448 · Cited by 1,720
Research works printed but not linked: 2
- Aubin J.E. Davies J.E. Osteogenic cell differentiation. Bone Engineering. Toronto: Em Squared Inc., 2000; 19–30.
- 10.1177/096368979700600206 · DOI
Cited by
Sorted by citations
Items 201–297 of 297
Tafti, Z. A., Mahmoodi, M., Hajizadeh, M. R., Ezzatizadeh, V., Baharvand, H., Vosough, M., & Piryaei, A. (2018) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2018.5288 · Cited by 11
Lu, W., Tang, Y. M., Zhang, Z., Zhang, X., Yao, Y., Fu, C., Wang, X., & Ma, G. (2015) · PubMed Central · Cited by 11
MARUYAMA, N., Kokubo, K., Shinbo, T., HIROSE, M., Kobayashi, M., Sakuragawa, N., & Kobayashi, H. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1412 · Cited by 12
Hua, P., Liu, J.-Y., Tao, J., & Yang, S. (2015) · BioMed Research International · doi:10.1155/2015/568502 · Cited by 10
Prado‐Lòpez, S., Duffy, M. M., Baustian, C., Alagesan, S., Hanley, S. A., Stocca, A., Griffin, M. D., & Ceredig, R. H. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.30 · Cited by 10
Biological Rationale for the Use of Vertebral Whole Bone Marrow in Spinal Surgery
Salamanna, F., Cepollaro, S., Contartese, D., Giavaresi, G., Bròdano, G. B., Griffoni, C., Gasbarrini, A., & Fini, M. (2018) · Spine · doi:10.1097/brs.0000000000002626 · Cited by 10
Silva, J. C., Moura, C. S., Borrecho, G., Matos, A., Cabral, J. M. S., Linhardt, R. J., & Ferreira, F. C. (2020) · International Journal of Polymeric Materials · doi:10.1080/00914037.2019.1706511 · Cited by 10
Lee, S. M., Jun, D. W., Kang, H. T., Oh, J., Saeed, W. K., & Ahn, S. B. (2021) · International Journal of Stem Cells · doi:10.15283/ijsc20096 · Cited by 10
Fu, W., Xiang, Z., Huang, F., Cen, S., Zhong, G., Duan, X., Liu, M., & Leung, F. K. L. (2015) · Cell and Tissue Banking · doi:10.1007/s10561-015-9527-4 · Cited by 10
Feng, X., Zhou, J., Chen, J.-Y., Feng, B. C., Hu, R., Wu, J., Pan, Q., Yang, J., Yu, J., & Cao, H. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i9.714 · Cited by 9
Wang, L., Bai, G., & Chen, F. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0127 · Cited by 9
Low-cost, open-source cell culture chamber for regulating physiologic oxygen levels
Marchus, C. R., Knudson, J. A., Morrison, A. E., Strawn, I. K., Hartman, A. J., Shrestha, D. S., Pancheri, N. M., Glasgow, I. K., & Schiele, N. R. (2021) · HardwareX · doi:10.1016/j.ohx.2021.e00253 · Cited by 9
Маслов, Л. Н., Podoksenov, Y. K., Portnychenko, A. G., & Naumova, A. V. (2013) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn.v68i12.855 · Cited by 9
Paracrine activity of multipotent mesenchymal stromal cells and its modulation in hypoxia
Andreeva, E. R., & Buravkova, L. B. (2013) · Human Physiology · doi:10.1134/s0362119713030043 · Cited by 9
Zhang, B., Ye, H., & Yang, A. (2018) · BMC Systems Biology · doi:10.1186/s12918-018-0560-3 · Cited by 10
Wang, D., Ji, Y. R., Chen, K., Du, W. T., Zhou, Y., Han, Z., Chi, Y., Liang, L., Bayard, F., & Han, Z. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000338509 · Cited by 8
Lee, J. S., Kim, H. S., Kim, S., Kim, D., & Lee, C. (2018) · PubMed Central · doi:10.14348/molcells.2018.2231 · Cited by 8
Barros, I., Marcelo, A., Silva, T. P., Barata, J., Rufino‐Ramos, D., de Almeida, L. P., & Miranda, C. O. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.584277 · Cited by 8
Romaniyanto, R., Prakoeswa, C. R. S., Tinduh, D., Notobroto, H. B., Rantam, F. A., Utomo, D. N., Suroto, H., & Ferdiansyah, F. (2021) · Indonesian Journal of Biotechnology · doi:10.22146/ijbiotech.63318 · Cited by 8
Tangtrongsup, S., & Kisiday, J. D. (2019) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-019-00566-3 · Cited by 7
Agata, H., Sumita, Y., Asahina, I., Tojo, A., & Kagami, H. (2013) · PubMed · doi:10.14670/hh-28.985 · Cited by 7
Kim, D. S., Lee, M. W., Ko, Y. J., Park, H. J., Park, Y. J., Kim, D.-I., Jung, H. L., Sung, K. W., Koo, H. H., & Yoo, K. H. (2016) · Biomedical Research · doi:10.2220/biomedres.37.311 · Cited by 7
Du, L., Lv, R., Yang, X., Cheng, S., Xu, J., & Ma, T. (2016) · Biotechnology Letters · doi:10.1007/s10529-016-2067-6 · Cited by 7
Large-scale in-vitro expansion of RBCs from hematopoietic stem cells
Ramesh, B., & Guhathakurta, S. (2012) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/10731199.2012.702315 · Cited by 7
Roato, I., Orrico, C., Meinardi, S., Pedraza, R., Balma, A. M., Baima, G., Genova, T., Aimetti, M., & Mussano, F. D. (2025) · Cells · doi:10.3390/cells14120864 · Cited by 6
Illuminating the Regenerative Properties of Stem Cells In Vivo with Bioluminescence Imaging
Madsen, S. D., Giler, M. K., Bunnell, B. A., & O’Connor, K. C. (2020) · Biotechnology Journal · doi:10.1002/biot.202000248 · Cited by 6
Peng, C., Yan, J., Jiang, Y., Wu, L., Li, M., & Fan, X. (2023) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-023-10438-x · Cited by 6
Direct pulp capping with autologous bone marrow derived stem cells in dogs.
Farzad‐Mohajeri, S., Pedram, M. S., Saeedifar, N., Abbas, F. M., Dehghan, M. M., Bahrami, N., & Hashemikamangar, S. S. (2022) · PubMed Central · doi:10.30466/vrf.2020.122172.2874 · Cited by 5
Baccouche, B. M., Elde, S., Wang, H., & Woo, Y. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00357-z · Cited by 6
Cytoprotection and Preconditioning for Stem Cell Therapy
Sharadadevi Mannur, Y., J., R., & Garber, J. J. (2011) · InTech eBooks · doi:10.5772/25296 · Cited by 5
Characteristics of Mesenchymal Stem Cells under Hypoxia
Amorin, B., Alegretti, A. P., Valim, V. D. S., da Silva, A. M. P., da Silva, M. A. L., Sehn, F., & Silla, L. M. D. R. (2013) · CellBio · doi:10.4236/cellbio.2013.21002 · Cited by 5
Tsiapalis, D., Ribeiro, S., Pieri, A. D., Sallent, I., Guillaumin, S., Gaspar, D., Korntner, S. H., Bayon, Y., Gomes, M. E., Reis, R. L., et al. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11140-7 · Cited by 6
ABC-transporters and drug efflux in hematologic cancers
Lazarowski, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816434-1.00006-1 · Cited by 5
Our NIH Years: A Confluence of Beginnings
Herzenberg, L. A., & Herzenberg, L. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.x112.426742 · Cited by 5
Najar, M., Dollé, L., Crompot, E., Verhulst, S., van Grunsven, L. A., Busser, H., & Lagneaux, L. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2017.0312 · Cited by 5
Sadeghi-Avalshahr, A., Nazarnezhad, S., Noughabi, M. K., Hassanzadeh, H., Namaei‐Ghasemnia, N., & Jalali, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145725 · Cited by 4
Minuth, W. W., & Denk, L. (2013) · Transplantation Technology · doi:10.7243/2053-6623-1-2 · Cited by 4
Genomic Analysis of Invasive Human Bone Marrow Derived Mesenchymal Stem Cells
Mathews, L. (2013) · Journal of Bone Marrow Research · doi:10.4172/2329-8820.1000122 · Cited by 4
Fine Tuning Mesenchymal Stromal Cells – Code For Mitigating Kidney Diseases
Makkar, D., Gakhar, D., Mishra, V., & Rakha, A. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10684-9 · Cited by 4
Dave, A., Kar, S., & Banerjee, E. R. (2018) · Biomedical Research and Therapy · doi:10.15419/bmrat.v5i4.434 · Cited by 4
Jin, H., Lee, W. J., Lee, S., Yi, T., Song, S. U., Shim, G., & Oh, Y. (2014) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-014-0156-x · Cited by 4
Loncaric, D., Stanković, B., Ghousein, A., Vreća, M., Spasovski, V., Villacreces, A., Debeissat, C., Grosset, C. F., Ivanović, Z., & Pavlović, S. (2019) · Archives of Biological Sciences · doi:10.2298/abs181117001l · Cited by 4
Hussain, Z. (2025) · Exploration of Digestive Diseases · doi:10.37349/edd.2025.100563 · Cited by 3
Where are Cell-Based Therapies Heading? Current Limitations and Future Directions
Suzuki, G., Young, R. F., & Suzuki, H. (2017) · Heart Research - Open Journal · doi:10.17140/hroj-4-144 · Cited by 3
Xu, Y., Rahman, M., Wang, Z., Zhang, B., Xie, H., Wang, L., Xu, H., Sun, X., Cheng, S., & Wu, Q. (2025) · eLife · doi:10.7554/elife.106023 · Cited by 3
Resistance of Multipotent Mesenchymal Stromal Cells to Anoxia In Vitro
Buravkova, L. B., Andreeva, E. R., Rylova, J. V., & Grigoriev, A. I. (2012) · InTech eBooks · doi:10.5772/28433 · Cited by 2
Cell Therapy for the Treatment of Chronic Ischemic Heart Disease
Rodrigo, S. F., van Ramshorst, J., Beeres, S. L. M. A., Bax, J. J., Schalij, M. J., & Atsma, D. E. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211797904172 · Cited by 2
Biomimetic chimeric peptide-tethered hydrogels for human mesenchymal stem cell delivery
Shim, G., Kim, G., Choi, J., Yi, T., Cho, Y. K., Song, S. U., Byun, Y., & Oh, Y. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.09.051 · Cited by 2
Eweida, A. M., Sandberg, E., Ritthaler, O., Fleckenstein, J., Abo‐Madyan, Y., Giordano, F. A., Schulte, M., Kneser, U., & Harhaus, L. (2024) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2024.03.020 · Cited by 2
Tissue Engineering Strategies for Cartilage Repair
Jahr, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-53316-2_10 · Cited by 2
Sharkey, J. V. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.09.162123 · Cited by 2
Тurdieva, S. T., Агзамова, Ш., & Khasanova, G. (2024) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-221-1-44-52 · Cited by 1
Xu, Y., Rahman, M., Wang, Z., Zhang, B., Xie, H., Wang, L., Xu, H., Sun, X., Cheng, S., & Wu, Q. (2025) · eLife · doi:10.7554/elife.106023.3 · Cited by 1
Bērziņš, U., Baroniņš, J., Sorokins, H., Goel, S., Shishkin, A., Zvirgzdina, R., Rautmane, A., & Minchev, D. S. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1687461 · Cited by 1
Effects of hypoxia on the biological characteristics of urine-derived stem cells
Xiao, Y., Guo, Z., Shao, W., Hq, X., & Huang, Y. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1851623 · Cited by 1
Umbilical cord stem cells: the hidden swan in a family of ugly ducklings
Mattei, T. A. (2012) · Acta Neurochirurgica · doi:10.1007/s00701-012-1437-7 · Cited by 1
Stem cells in musculoskeletal system for clinical application
Min, B., & Li, T. Z. (2011) · Journal of Korean Medical Association · doi:10.5124/jkma.2011.54.5.491 · Cited by 1
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Chacko, S. M., & Kuppusamy, P. (2013) · CRC Press eBooks · doi:10.1201/b14663-15 · Cited by 1
Mesenchymal Stromal Cells: Clinical Experience, Challenges, and Future Directions
Hematti, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802826-1.00012-x · Cited by 1
Dionigi, B. (2013) · AAP National Conference and Exhibition · Cited by 1
Methods and Practices to Diversify Cell-Based Products
Vertès, A. A. (2017) · Regenerative Medicine · doi:10.2217/rme-2017-0093 · Cited by 1
(2014) · Journal of Transplantation & Stem Cell Biology · doi:10.13188/2374-9326.1000006 · Cited by 1
HypoxamiR-210-3p regulates mesenchymal stem cells proliferation via P53 & Akt
Kumar, S., Yadav, V., Sharma, N., & Sethi, A. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04834-9 · Cited by 1
Detection of hypoxia in the pulmonary tissues of Xenopus laevis over repeated dives
Fujiyama, S., Okui, T., & Kato, T. (2023) · Development Growth & Differentiation · doi:10.1111/dgd.12837 · Cited by 1
Kuster, G. M., & Liao, R. (2016) · Circulation Research · doi:10.1161/circresaha.116.308410 · Cited by 1
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Hanna, B. (2014) · Scholar Commons (University of South Carolina)
Impact of Growth Factors on the Proliferation of Ear Mesenchymal Stem Cells on Porous Microcarriers
Sart, S., Schneider, Y., & Agathos, S. N. (2011) · Springer eBooks · doi:10.1007/978-94-007-0884-6_27
Curley, G. F. (2012) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/17147
Аверьянов, А. В., Конопляников, А. Г., Al, C., Петров, В. Н., Konopliannikova, O. A., Агаева, Е. В., Tsyb, A. F., Kuzovlev, O. P., Брюховецкий, А. С., Kulagina, N. S., et al. (2011) · Genes and Cells
Mesenchymal Stem/Stromal Cells: Opportunities and Obstacles in ARDS
Curley, G. F., Hayes, M., & Laffey, J. G. (2013) · Springer eBooks · doi:10.1007/978-3-642-35109-9_38
Маслов, Л. Н., Podoksenov, Y. K., Портниченко, А. Г., & Russian Federation (2013)
Molecular Mechanisms of Smooth Muscle Cell Differentiation from Adipose-Derived Stem Cell
Wang, F., & Emmersen, J. (2022) · River Publishers eBooks · doi:10.1201/9781003339779-9
Qian, Z., Xing, Q., Fase, C., Jansen, K., & Zhao, F. (2017) · AIMS Cell and Tissue Engineering · doi:10.3934/celltissue.2017.1.47
Xie, L. Y. (2011) · Louisiana State University · doi:10.31390/gradschool_dissertations.3799
Alfaifi, M. A., Vigneswara, V., Luu, N., Baan, C. C., Hoogduijn, M. J., Gargesha, M., Roy, D., Elliman, S. J., O’Flynn, L., Hirschfield, G. M., et al. (2018) · Journal of Hepatology · doi:10.1016/s0168-8278(18)31153-x
Angiogenesis: Perspectives from Therapeutic Angiogenesis
Bethel, M., Arora, V., & Annex, B. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-56954-9_6
Effects of allogeneic mesenchymal stem cells in experimental treatment of pulmonary emphysema
Averyanov, A. V., Kuzovlev, O. P., Kulagina, N., Георгиевич, К. А., Petrov, V. A., Konoplyannikova, O. A., Агаева, Е. В., Tsyb, A. F., Bruhovetsky, А., Trusov, A., et al. (2011) · Journal of clinical practice · doi:10.17816/clinpract83655
Zayed, M., Iohara, K., Watanabe, H., Ishikawa, M., Tominaga, M., & Nakashima, M. (2021) · Research Square · doi:10.21203/rs.3.rs-102950/v2
Wang, H., Cai, Z., Song, P., Liu, D., Jiang, F., Xu, B., & Zhang, T. (2022) · Research Square · doi:10.21203/rs.3.rs-2013471/v1
Shephard, M. T., Merkhan, M. M., Dale, T. P., & Forsyth, N. R. (2023) · Research Square · doi:10.21203/rs.3.rs-3006436/v1
Efeitos da hipóxia em células-tronco mesenquimais sobre-expressando BMP-9
PAZ, J. E. R. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.58.2023.tde-23102023-153320
Hypoxia inhibits newt skeletal muscle dedifferentiationPreprint
Vdovin, G., Walters, H., Troyanovskiy, K. E., Tsuchiya, Y., & Yun, M. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.29.626015
Xu, Y., Rahman, M., Wang, Z., Zhang, B., Xie, H., Wang, L., Xu, H., Sun, X., Cheng, S., & Wu, Q. (2025) · eLife · doi:10.7554/elife.106023.1
Pont, J. J. H. H. M. D., Singh, P. K., & Singh, V. P. (2025) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00463-4
Xu, Y., Rahman, M., Wang, Z., Zhang, B., Xie, H., Wang, L., Xu, H., Sun, X., Cheng, S., & Wu, Q. (2025) · eLife · doi:10.7554/elife.106023.2
Zayed, M., Iohara, K., Watanabe, H., Ishikawa, M., Tominaga, M., & Nakashima, M. (2021) · Figshare · doi:10.6084/m9.figshare.14702221
Elashry, M. I., Kinde, M., Klymiuk, M. C., Eldaey, A., Wenisch, S., & Arnhold, S. (2022) · Figshare · doi:10.6084/m9.figshare.19128863
Femtosecond Laser Engraving Promotes the Repopulation of Decellularized Human Articular Cartilage
Schneider, C., Zehetner, J., Schädl, B., Domke, M., Keibl, C., Rieder, B., Heimel, P., Kleiner, A., Teuschl, A., Wolbank, S., et al. (2025) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1155/term/2334978
Zhao, Z., Zhang, H., Zhou, F., Yang, Y., Huang, B., & Liu, X. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110754
Leroux, L. (2010) · theses.fr (ABES) · doi:10.70675/e100813fz05e6z4691za9bbz1f96950e43c1
Valokola, M. G., Ahmadi, F., Bayat, R., Haeri, S. M. J., Fallahnezhad, S., & Sahebkar, A. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00503-z
Current Status and Future Directions in Regenerative Endodontic Therapy
Wang, X., & Gao, B. (2026) · International Dental Journal · doi:10.1016/j.identj.2026.111225
Metadata
- Authors
- Das, R., Jahr, H., van Osch, G. J. V. M., & Farrell, E.
- Affiliations
- Erasmus MC (NL)
- University Medical Center Rotterdam,
- Corresponding author
- Farrell, Eric
- Venue
- Tissue Engineering Part B Reviews
- Publisher
- SAGE Publications
- Published
- 2009-10-09
- Volume
- 16
- Issue
- 2
- Pages
- 159-168
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W2017720509
- Cited by
- 297
- References
- 107
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 26 · 2017: 19 · 2016: 19 · 2015: 24 · 2014: 30 · 2013: 26 · 2012: 24
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tissue Engineering Part B Reviews (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Dutch Arthritis Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- hypoxia, bone marrow-derived mesenchymal stem cells, oxygen partial pressure, hypoxic preconditioning, apoptosis, Akt signaling, cell proliferation, multilineage differentiation, paracrine signaling, angiogenic factors, vascular endothelial growth factor, interleukin-6, CXCL12, CXCR4, stem cell homing, stem cell mobilization, regenerative medicine
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Cell Survival, Humans, Models, Biological, Cell Hypoxia, Regenerative Medicine, Cell Proliferation, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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