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The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches
Abstract
Bone marrow-derived mesenchymal stem cells (MSCs) have demonstrated potential for regenerative medicine strategies. Knowledge of the way these cells respond to their environment in in vitro culture and after implantation in vivo is crucial for successful therapy. Oxygen tension plays a pivotal role in both situations. In vivo, a hypoxic environment can lead to apoptosis, but hypoxic preconditioning of MSCs and overexpression of prosurvival genes like Akt can reduce hypoxia-induced cell death. In cell culture, hypoxia can increase proliferation rates and enhance differentiation along the different mesenchymal lineages. Hypoxia also modulates the paracrine activity of MSCs, causing upregulation of various secretable factors, among which are important angiogenic factors such as vascular endothelial growth factor and interleukin-6 (IL6). Finally, hypoxia plays an important role in mobilization and homing of MSCs, primarily by its ability to induce stromal cell-derived factor-1 expression along with its receptor CXCR4. This article reviews the current literature on the effects of hypoxia on MSCs and aims to elucidate its potential role in regenerative medicine strategies.
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“hypoxia-mediated preconditioning of BM-MSCs could reduce hypoxia-induced cell death and increase BM-MSCs proliferation and differentiation [8] in vitro.”
From Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice (2014) · cites this paper as [8]
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Metadata
- Authors
- Das, R., Jahr, H., van Osch, G. J. V. M., & Farrell, E.
- Affiliations
- Erasmus MC (NL)
- University Medical Center Rotterdam,
- Corresponding author
- Farrell, Eric
- Venue
- Tissue Engineering Part B Reviews
- Publisher
- SAGE Publications
- Published
- 2009-10-09
- Volume
- 16
- Issue
- 2
- Pages
- 159-168
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W2017720509
- Cited by
- 297
- References
- 107
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 26 · 2017: 19 · 2016: 19 · 2015: 24 · 2014: 30 · 2013: 26 · 2012: 24
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tissue Engineering Part B Reviews (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Dutch Arthritis Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- hypoxia, bone marrow-derived mesenchymal stem cells, oxygen partial pressure, hypoxic preconditioning, apoptosis, Akt signaling, cell proliferation, multilineage differentiation, paracrine signaling, angiogenic factors, vascular endothelial growth factor, interleukin-6, CXCL12, CXCR4, stem cell homing, stem cell mobilization, regenerative medicine
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Cell Survival, Humans, Models, Biological, Cell Hypoxia, Regenerative Medicine, Cell Proliferation, Mesenchymal Stem Cells
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