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Cited by 695

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Outcomes of Patients with Differentiated Thyroid Carcinoma Following Initial Therapy

Jonklaas, Jacqueline, Sarlis, Nicholas J., Litofsky, Danielle, Ain, Kenneth B., Bigos, S. Thomas, Brierley, James D., Cooper, David S., Haugen, Bryan R., Ladenson, Paul W., Magner, James, Robbins, Jacob, Ross, Douglas S., Skarulis, Monica, Maxon, Harry R., Sherman, Steven I.·2006·Thyroid
DOI 10.1089/thy.2006.16.1229
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Abstract

This analysis was performed to determine the effect of initial therapy on the outcomes of thyroid cancer patients. The study setting was a prospectively followed multi-institutional registry. Patients were stratified as low risk (stages I and II) or high risk (stages III and IV). Treatments employed included near-total thyroidectomy, administration of radioactive iodine, and thyroid hormone suppression therapy. Outcome measures were overall survival, disease-specific survival, and disease-free survival. Near-total thyroidectomy, radioactive iodine, and aggressive thyroid hormone suppression therapy were each independently associated with longer overall survival in high-risk patients. Near-total thyroidectomy followed by radioactive iodine therapy, and moderate thyroid hormone suppression therapy, both predicted improved overall survival in stage II patients. No treatment modality, including lack of radioactive iodine, was associated with altered survival in stage I patients. Based on our overall survival data, we confirm that near-total thyroidectomy is indicated in high-risk patients. We also conclude that radioactive iodine therapy is beneficial for stage II, III, and IV patients. Importantly, we show for the first time that superior outcomes are associated with aggressive thyroid hormone suppression therapy in high-risk patients, but are achieved with modest suppression in stage II patients. We were unable to show any impact, positive or negative, of specific therapies in stage I patients.

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Authors
Jonklaas, J., Sarlis, N. J., Litofsky, D., Ain, K. B., Bigos, S. T., Brierley, J. D., Cooper, D. S., Haugen, B. R., Ladenson, P. W., Magner, J., Robbins, J., Ross, D. S., Skarulis, M., Maxon, H. R., & Sherman, S. I.
Venue
Thyroid
Publisher
SAGE Publications
Published
2006-12
Volume
16
Issue
12
Pages
1229-1242
ISSN
  • 1050-7256 (ISSN-L)
  • 1557-9077
DOI
10.1089/thy.2006.16.1229
OpenAlex
W1975344814
Cited by
695
References
0
FWCI
14.52
Type
journal article
Language
en
Open access
closed

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