The Role of Propylthiouracil in the Management of Graves' Disease in Adults: Report of a Meeting Jointly Sponsored by the American Thyroid Association and the Food and Drug Administration
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Udgivelsesdato: 2009
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If not recognized, PTU-induced hepatotoxicity can lead to liver failure and death.
“If not recognized, it can lead to liver failure and death (115,157-159).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [157]
Cites
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“FDA to recommended that PTU be reserved for patients who are in their first trimester of pregnancy or who are allergic to or intolerant of MMI (157,470) MMI and PTU both appear in breast milk in only small concentrations, and studies of breastfed infants of mothers taking ATDs have demonstrated normal thyroid function…”
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- Authors
- Bahn, R. S., Burch, H. S., Cooper, D. S., Garber, J. R., Greenlee, C. M., Klein, I. L., Laurberg, P., McDougall, I. R., Rivkees, S. A., Ross, D., Sosa, J. A., & Stan, M. N.
- Affiliations
- Mayo Clinic (US)
- Walter Reed National Military Medical Center (US)
- Johns Hopkins University (US)
- Harvard Vanguard Medical Associates (US)
- Saint John's Health Center (US)
- North Shore University Hospital (US)
- Aalborg University Hospital (DK)
- Stanford Medicine (US)
- Yale University (US)
- Harvard University (US)
- Corresponding author
- Bahn, Rebecca S.
- ORCID
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2009-07
- Volume
- 19
- Issue
- 7
- Pages
- 673-674
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W1975945740
- Cited by
- 223
- References
- 2
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 9 · 2016: 19 · 2015: 22 · 2014: 13 · 2013: 16 · 2012: 26
- FWCI
- 15.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- propylthiouracil, Graves' disease, antithyroid drug therapy, hyperthyroidism management, adults
- MeSH terms
- Adult, Female, Graves Disease, Humans, Methimazole, Pregnancy, Propylthiouracil, Societies, Medical, Antithyroid Agents, United States, United States Food and Drug Administration, Liver Failure
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