A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia
Open accessAbstract
Background: Glycogen storage disease type Ia (GSD Ia), also known as von Gierke disease, is the most common glycogen storage disorder. It is caused by the deficiency of glucose-6-phosphatase, the enzyme that catalyzes the final step of gluconeogenesis and glycogenolysis. The accumulation of glucose-6-phosphate leads to increased glycogen and triglyceride levels in the liver. Patients with GSD Ia can develop steatohepatitis, cirrhosis, and increased risk for hepatocellular adenomas and carcinomas. We previously showed that animal models of GSD Ia had defective autophagy and dysfunctional mitochondria. In this study, we examined the effect of VK2809, a liver-specific thyroid hormone receptor β agonist, on hepatic steatosis, autophagy, and mitochondrial biogenesis in a mouse model of GSD Ia. Methods: G6pc -/- -deficient (GSD Ia) mice were treated with VK2809 or vehicle control by daily intraperitoneal injection for four days. The hepatic triglyceride and glycogen were determined by biochemical assays. Autophagy and mitochondrial biogenesis were measured by Western blotting for key autophagy and mitochondrial markers. Results: VK2809 treatment decreased hepatic mass and triglyceride content in GSD Ia mice. VK2809 stimulated hepatic autophagic flux as evidenced by increased microtubule-associated protein light chain 3-II (LC3B-II), decreased p62 protein levels, activation of AMP-activated protein kinase (AMPK), inhibition of the mammalian target of rapamycin (mTOR) signaling, enha…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
VK2809, a liver-specific THRβ agonist, decreased hepatic triglyceride levels in mice by simultaneous restoration of autophagy, mitochondrial biogenesis, and β-oxidation of fatty acids.
“VK2809, a liver-specific THRβ agonist, decreased hepatic triglyceride levels in mice by simultaneous restoration of autophagy, mitochondrial biogenesis, and β-oxidation of fatty acids (80).”
From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [80]
Cites
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · see citing works
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works
Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1
Bjørkøy, G., Lamark, T., Pankiv, S., Øvervatn, A., Brech, A., & Johansen, T. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03612-4 · Cited by 1,145 · see citing works
Direct effects of thyroid hormones on hepatic lipid metabolism
Sinha, R. A., Singh, B. K., & Yen, P. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.10 · Cited by 665 · see citing works
Self-citationKishnani, P. S., Austin, S. L., Abdenur, J. E., Arn, P. H., Bali, D. S., Boney, A., Chung, W. K., Dagli, A. I., Dale, D. C., Koeberl, D. D., et al. (2014) · Genetics in Medicine · doi:10.1038/gim.2014.128 · Cited by 499 · see citing works
Self-citationMeta-analysis: Subclinical Thyroid Dysfunction and the Risk for Coronary Heart Disease and Mortality
Ochs, N., Auer, R., Bauer, D. C., Nanchen, D., Gussekloo, J., Cornuz, J., & Rodondi, N. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-11-200806030-00225 · Cited by 477 · see citing works
Fisher, C. D., Lickteig, A. J., Augustine, L. M., Ranger‐Moore, J., Jackson, J. P., Ferguson, S., & Cherrington, N. J. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.027466 · Cited by 352 · see citing works
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
Sinha, R. A., Farah, B. L., Singh, B. K., Siddique, M. M., Li, Y., Wu, Y., Ilkayeva, O., Gooding, J. R., Ching, J., Zhou, J., et al. (2013) · Hepatology · doi:10.1002/hep.26667 · Cited by 343 · see citing works
Self-citationSunny, N. E., Bril, F., & Cusi, K. J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.11.006 · Cited by 321 · see citing works
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy
Sinha, R. A., You, S.-H., Zhou, J., Siddique, M. M., Bay, B.-H., Zhu, X., Privalsky, M. L., Cheng, S.-Y., Stevens, R. D., Summers, S. A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60580 · Cited by 303 · see citing works
Self-citationLiver autophagy contributes to the maintenance of blood glucose and amino acid levels
Ezaki, J., Matsumoto, N., Takeda‐Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., et al. (2011) · Autophagy · doi:10.4161/auto.7.7.15371 · Cited by 282 · see citing works
Kim, S.-J., Tang, T., Abbott, M. J., Viscarra, J. A., Wang, Y., & Sul, H. S. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00244-16 · Cited by 278 · see citing works
Erion, M. D., Cable, E. E., Ito, B. R., Jiang, H., Fujitaki, J. M., Finn, P. D., Zhang, B., Hou, J., Boyer, S. H., van Poelje, P. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702759104 · Cited by 273 · see citing works
Glucose-6-phosphatase deficiency
Froissart, R., Piraud, M., Mollet-Boudjemline, A., Vianey‐Saban, C., Petit, F. M., Hubert-Buron, A., Eberschweiler, P. T., Gajdos, V., & Labrune, P. (2011) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-6-27 · Cited by 264 · see citing works
Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy
CHOU, J. Y., Jun, H. S., & Mansfield, B. C. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.189 · Cited by 233 · see citing works
Kelly, M. J., Pietranico-Cole, S., Larigan, J. D., Haynes, N.-E., Reynolds, C. H., Scott, N., Vermeulen, J., Dvorozniak, M., Conde-Knape, K., Huang, K.-S., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm4019299 · Cited by 231 · see citing works
Yau, W. W., Singh, B. K., Lesmana, R., Zhou, J., Sinha, R. A., Wong, K. A., Wu, Y., Bay, B.-H., Sugii, S., Sun, L., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1511263 · Cited by 229 · see citing works
Self-citationSinha, R. A., Singh, B. K., Zhou, J., Wu, Y., Farah, B. L., Ohba, K., Lesmana, R., Gooding, J. R., Bay, B., & Yen, P. M. (2015) · Autophagy · doi:10.1080/15548627.2015.1061849 · Cited by 208 · see citing works
Self-citationCable, E. E., Finn, P. D., Stebbins, J. W., Hou, J., Ito, B. R., van Poelje, P. D., Linemeyer, D. L., & Erion, M. D. (2008) · Hepatology · doi:10.1002/hep.22572 · Cited by 206 · see citing works
The role of glucose 6‐phosphate in the control of glycogen synthase
Viijlar‐Palasí, C., & Guinovart, J. J. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212078 · Cited by 196 · see citing works
Function of Autophagy in Nonalcoholic Fatty Liver Disease
Czaja, M. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-4025-x · Cited by 193 · see citing works
Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.014 · Cited by 191 · see citing works
Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle
Demartino, G., & Goldberg, A. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.3.1369 · Cited by 150 · see citing works
Thyroid hormone (T3) and TRβ agonist GC‐1 inhibit/reverse nonalcoholic fatty liver in rats
Perra, A., Simbula, G., Simbula, M., Pibiri, M., Kowalik, M. A., Sulas, P., Cocco, M. T., Ledda‐Columbano, G. M., & Columbano, A. (2008) · The FASEB Journal · doi:10.1096/fj.08-108464 · Cited by 147 · see citing works
Singh, B. K., Sinha, R. A., Tripathi, M., Mendoza, A., Ohba, K., Sy, J. A. C., Xie, S. Y., Zhou, J., Ho, J. P., Chang, C.-Y., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aam5855 · Cited by 145 · see citing works
Self-citationMutel, E., Abdul-Wahed, A., Ramamonjisoa, N., Stefanutti, A., Houberdon, I., Cavassila, S., Pilleul, F., Beuf, O., Gautier‐Stein, A., Penhoat, A., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.08.014 · Cited by 138 · see citing works
Bruinstroop, E., Dalan, R., Cao, Y., Bee, Y. M., Chandran, K., Cho, L. W., Soh, S. B., Teo, E. K., Toh, S.-A., Leow, M. K. S., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00475 · Cited by 108 · see citing works
Self-citationInduction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency
Farah, B. L., Landau, D. J., Sinha, R. A., Brooks, E. D., Wu, Y., Fung, S. Y. S., Tanaka, T., Hirayama, M., Bay, B., Koeberl, D. D., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.008 · Cited by 97 · see citing works
Self-citationLesmana, R., Sinha, R. A., Singh, B. K., Zhou, J., Ohba, K., Wu, Y., Yau, W. W. Y., Bay, B., & Yen, P. M. (2015) · Endocrinology · doi:10.1210/en.2015-1632 · Cited by 97 · see citing works
Self-citationBandsma, R., Prinsen, B. H. C. M. T., der Velden, M. G. M. D. S., Rake, J. P., Boer, T. S., Smit, G., Reijngoud, D., & Kuipers, F. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e31816c9013 · Cited by 89 · see citing works
Koeberl, D. D., Sun, B., Damodaran, T. V., Brown, T. T., Millington, D. S., Benjamin, D. K., Bird, A., Schneider, A., Hillman, S. L., Jackson, M., et al. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302774 · Cited by 77 · see citing works
Self-citationCho, J., Kim, G.-Y., Pan, C., Anduaga, J., Choi, E., Mansfield, B. C., & CHOU, J. Y. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006819 · Cited by 75 · see citing works
Changes in Thyroid Status During Perinatal Development of MCT8-Deficient Male Mice
Ferrara, A. M., Liao, X.-H., Gil-Ibáñez, P., Marcinkowski, T., Bernal, J., Weiss, R. E., Dumitrescu, A. M., & Refetoff, S. (2013) · Endocrinology · doi:10.1210/en.2012-2031 · Cited by 70 · see citing works
Self-citationKotoulas, O. B., Kalamidas, S. A., & Kondomerkos, D. J. (2004) · Microscopy Research and Technique · doi:10.1002/jemt.20046 · Cited by 70 · see citing works
Monteillet, L., Gjorgjieva, M., Silva, M., Verzieux, V., Imikirene, L., Duchampt, A., Guillou, H., Mithieux, G., & Rajas, F. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.07.006 · Cited by 64 · see citing works
Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)
Farah, B. L., Sinha, R. A., Wu, Y., Singh, B. K., Lim, A. R., Hirayama, M., Landau, D. J., Bay, B., Koeberl, D. D., & Yen, P. M. (2017) · Scientific Reports · doi:10.1038/srep44408 · Cited by 57 · see citing works
Self-citationEmerging therapies for glycogen storage disease type I
Koeberl, D. D., Kishnani, P. S., Bali, D. S., & Chen, Y.-T. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.02.003 · Cited by 50 · see citing works
Self-citationWaskowicz, L. R., Zhou, J., Landau, D. J., Brooks, E. D., Lim, A. R., Yavarow, Z. A., Kudo, T., Zhang, H., Wu, Y., Grant, S., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy343 · Cited by 47 · see citing works
Self-citationGjorgjieva, M., Caldéraro, J., Monteillet, L., Silva, M., Raffin, M., Brevet, M., Romestaing, C., Roussel, D., Zucman‐Rossi, J., Mithieux, G., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.07.017 · Cited by 45 · see citing works
Wang, G., Young, S. P., Bali, D. S., Hutt, J. A., Li, S., Benson, J. M., & Koeberl, D. D. (2014) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2014.18 · Cited by 40 · see citing works
Self-citationFujitaki, J. M., Cable, E. E., Ito, B. R., Zhang, B., Hou, J., Yang, C. Z., Bullough, D. A., Ferrero, J. L., van Poelje, P. D., Linemeyer, D. L., et al. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.021642 · Cited by 36 · see citing works
Sever, S., Weinstein, D. A., Wolfsdorf, J. I., Gedik, R., & Schaefer, E. J. (2012) · Journal of clinical lipidology · doi:10.1016/j.jacl.2012.08.005 · Cited by 25 · see citing works
Recent development and gene therapy for glycogen storage disease type Ia
CHOU, J. Y., Kim, G., & Cho, J. (2017) · Liver Research · doi:10.1016/j.livres.2017.12.001 · Cited by 17 · see citing works
Thyroid Hormones Regulate Hepatic Glycogen Synthase*
Malbon, C. C., & Campbell, R. E. (1984) · Endocrinology · doi:10.1210/endo-115-2-681 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus
Ferguson, D., & Finck, B. N. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00507-z · Cited by 507 · see citing works
Negi, C. K., Babica, P., Bajard, L., Vašků, J. B., & Tarantino, G. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154925 · Cited by 193 · see citing works
Saponaro, F., Sestito, S., Runfola, M., Rapposelli, S., & Chiellini, G. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00331 · Cited by 124 · see citing works
Zhou, Z., Wang, H., Zhang, X., Song, M., Yao, S., Jiang, P., Liu, D., Wang, Z., Lv, H., Li, R., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2038994 · Cited by 114 · see citing works
NAFLD and thyroid function: pathophysiological and therapeutic considerations
Hatziagelaki, E., Paschou, S. A., Schön, M., Psaltopoulou, T., & Roden, M. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.08.001 · Cited by 93 · see citing works
Zhou, J., Tripathi, M., Ho, J. P., Widjaja, A. A., Shekeran, S. G., Camat, M. D., James, A., Wu, Y., Ching, J., Kovalik, J., et al. (2022) · Thyroid · doi:10.1089/thy.2021.0621 · Cited by 86 · see citing works
Self-citationLuong, X. G., Stevens, S., Jekle, A., Lin, T., Gupta, K., Misner, D., Chanda, S. M., Mukherjee, S., Williams, C., Stoycheva, A. D., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240338 · Cited by 77 · see citing works
Actions of thyroid hormones and thyromimetics on the liver
Sinha, R. A., Bruinstroop, E., & Yen, P. M. (2024) · Nature reviews: Gastroenterology & hepatology · doi:10.1038/s41575-024-00991-4 · Cited by 64 · see citing works
Self-citationKim, Y. S., & Kim, S. G. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0173 · Cited by 62 · see citing works
Runfola, M., Sestito, S., Bellusci, L., Pietra, V. L., D’Amore, V. M., Kowalik, M. A., Chiellini, G., Gul, S., Perra, A., Columbano, A., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.112006 · Cited by 59 · see citing works
Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review
Fu, Z., Zhao, P., Yang, X.-P., Li, H., Hu, S.-D., Xu, Y., & Du, X.-H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1094020 · Cited by 56 · see citing works
Bioenergetic Aspects of Mitochondrial Actions of Thyroid Hormones
Cioffi, F., Giacco, A., Goglia, F., & Silvestri, E. (2022) · Cells · doi:10.3390/cells11060997 · Cited by 55 · see citing works
MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism
Zhou, J., Singh, B. K., Ho, J. P., Lim, A. R., Bruinstroop, E., Ohba, K., Sinha, R. A., & Yen, P. M. (2021) · Autophagy · doi:10.1080/15548627.2021.1899691 · Cited by 48 · see citing works
Self-citationThyroid Hormone Receptor-β Agonists in NAFLD Therapy: Possibilities and Challenges
Li, L., Song, Y., Shi, Y., & Sun, L. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad072 · Cited by 45 · see citing works
Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis
Wirth, E. K., Puengel, T., Spranger, J., & Tacke, F. (2022) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2022.2110864 · Cited by 42 · see citing works
Ramanathan, R., Patwa, S. A., Ali, A. H., & Ibdah, J. A. (2023) · Cells · doi:10.3390/cells12242806 · Cited by 47 · see citing works
Emerging Therapies in Hypothyroidism
Bianco, A. C. (2024) · Annual Review of Medicine · doi:10.1146/annurev-med-060622-101007 · Cited by 36 · see citing works
Potential role of two novel agonists of thyroid hormone receptor‐β on liver regeneration
Perra, A., Kowalik, M. A., Cabras, L., Runfola, M., Sestito, S., Migliore, C., Giordano, S., Chiellini, G., Rapposelli, S., & Columbano, A. (2020) · Cell Proliferation · doi:10.1111/cpr.12808 · Cited by 35 · see citing works
Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
Petagine, L., Zariwala, M. G., & Patel, V. B. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i32.4831 · Cited by 37 · see citing works
Resmetirom: The First Disease‐Specific Treatment for MASH
Mousa, A. M., Mahmoud, M., & AlShuraiaan, G. M. (2025) · International Journal of Endocrinology · doi:10.1155/ije/6430023 · Cited by 34 · see citing works
Development of Thyroid Hormones and Synthetic Thyromimetics in Non-Alcoholic Fatty Liver Disease
Zhao, M., Xie, H., Shan, H., Zheng, Z., Li, G., Li, M., & Hong, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031102 · Cited by 31 · see citing works
Hu, Y., Sun, C., Chen, Y., Liu, Y., & Fan, J. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2024.00123 · Cited by 32 · see citing works
Oliveira, L. S. D., & Ritter, M. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000596 · Cited by 32 · see citing works
Yavarow, Z. A., Kang, H., Waskowicz, L. R., Bay, B., Young, S. P., Yen, P. M., & Koeberl, D. D. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz290 · Cited by 28 · see citing works
Self-citationZhou, J., Gauthier, K. C., Ho, J. P., Lim, A. R., Zhu, X., Han, C. R., Sinha, R. A., Cheng, S.-Y., & Yen, P. M. (2021) · Endocrinology · doi:10.1210/endocr/bqab112 · Cited by 30 · see citing works
Self-citationPathogenesis and Therapeutic Strategies Related to Non-Alcoholic Fatty Liver Disease
Teng, T., Qiu, S., Zhao, Y., Zhao, S., Sun, D., Hou, L., Li, Y., Zhou, K., Yu, X., Yang, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147841 · Cited by 26 · see citing works
Thyroid hormone receptor beta: Relevance in human health and diseases
Rehman, G., Kumari, N., Bano, F., & Tyagi, R. K. (2023) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2023.100144 · Cited by 26 · see citing works
Huisman, T. M., Dieterich, D. T., & Friedman, S. L. (2021) · Journal of Experimental Pharmacology · doi:10.2147/jep.s265286 · Cited by 23 · see citing works
Wang, K., Chen, F., Wang, J., & Liu, H. S. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.07.025 · Cited by 21 · see citing works
Zhong, J., Gou, Y., Zhao, P., Dong, X., Guo, M., Li, A., Hao, A., Luu, H. H., He, T., Reid, R. R., et al. (2023) · Pediatric Discovery · doi:10.1002/pdi3.3 · Cited by 17 · see citing works
Liu, A., Huang, M.-T., Xi, Y., Deng, X.-L., & Xu, K.-S. (2025) · Biomedicines · doi:10.3390/biomedicines13061422 · Cited by 16 · see citing works
The roles of autophagy and thyroid hormone in the pathogenesis and treatment of NAFLD
Zhou, J., Sinha, R. A., & Yen, P. M. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2021.82 · Cited by 17 · see citing works
Self-citationPu, S., Zhao, B., Jiang, Y., & Cui, X. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02474-0 · Cited by 16 · see citing works
Drug Pipeline for MASLD: What Can Be Learned from the Successful Story of Resmetirom
Knezović, E., Hefer, M., Blažanović, S., Petrović, A., Tomičić, V., Srb, N., Kirner, D., Smolić, R., & Smolić, M. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47030154 · Cited by 16 · see citing works
Wu, Y., Dong, P., Wu, Q., Zhang, Y., Xu, G., Pan, C., & Tong, H. (2025) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3606 · Cited by 15 · see citing works
Future Treatment Options and Regimens for Nonalcoholic Fatty Liver Disease
Francque, S., & Ratziu, V. (2023) · Clinics in Liver Disease · doi:10.1016/j.cld.2023.01.010 · Cited by 12 · see citing works
Targeting THR-β for MASLD Treatment: Current Progression and Emerging Prospects.
Li, J.-W., Chen, R., Zhang, J.-H., He, J.-H., Wang, Y.-X., & Li, Y. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03114 · Cited by 10 · see citing works
Huang, S., Deng, Z., Wang, W., Liao, G., Zhao, Y., Zhong, H., Zhang, Q., Liu, J., Mao, X., Chen, B., et al. (2023) · International Journal of Endocrinology · doi:10.1155/2023/4950597 · Cited by 11 · see citing works
Intracellular spatiotemporal metabolism in connection to target engagement
Zhang, J., Qiu, Z., Zhang, Y. J., Wang, G., & Hao, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115024 · Cited by 10 · see citing works
Cho, J., Weinstein, D. A., & Lee, Y. (2020) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12267 · Cited by 9 · see citing works
Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome.
dos Santos, B. G., Brisnovali, N. F., & Goedeke, L. (2024) · Biochemical Journal · doi:10.1042/bcj20240005 · Cited by 5 · see citing works
Rossi, A., Simeoli, C., Pivonello, R., Salerno, M., Rosano, C., Brunetti, B., Strisciuglio, P., Colao, A. A. L., Parenti, G., Melis, D., et al. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-024-09880-2 · Cited by 6 · see citing works
Thyroid Hormone Analogs: Recent Developments
Freund, M., van Geest, F. S., Groeneweg, S., van Geest, F. S., & Visser, W. E. (2025) · Thyroid · doi:10.1089/thy.2025.0245 · Cited by 6 · see citing works
Zhang, M., Lv, X., Wang, C., Wang, L., Wang, H., Wang, X., Du, Y., Li, J., Han, X., Fan, L., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1595566 · Cited by 5 · see citing works
Emerging Therapies and Therapeutic Targets for Composite Liver Disease: NASH
Sobhia, M. E., Kumari, S., Kumar, H., Gandhe, A., Kaushik, D., Kumar, H., Jain, J., Ankita, A., Mallick, M., Pavani, B., et al. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230714113808 · Cited by 4 · see citing works
Patel, R. B., Barnwal, S. K., A, A. M. S. M., & Francis, D. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.10.001 · Cited by 4 · see citing works
Recent advances in the treatment of non-alcoholic fatty liver disease with astragaloside IV
Wang, H., Jiang, Y., Wang, S., Lu, C., Tang, L., Gu, T., & Shu, S. (2025) · Acta Pharmaceutica · doi:10.2478/acph-2025-0022 · Cited by 3 · see citing works
Organophosphorus compounds and neurological conditions: Dr. Jekyll and Mr. Hyde
Aztiria, E., & Baier, C. J. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107563 · Cited by 3 · see citing works
Targeting THR-β for MASLD: Mechanisms and Drug Development
Hua, Y., Liu, Y., Xing, L.-J., Yu, X., Zheng, P.-Y., Yang, L., & Song, H.-Y. (2025) · Drug Design, Development and Therapy · doi:10.2147/dddt.s558221 · Cited by 4 · see citing works
Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions
Qu, J., Qin, W., Dong, M., Ma, Z., Li, S., Liu, R., Chen, R., Li, C. H., & Li, X. (2026) · MedComm · doi:10.1002/mco2.70750 · Cited by 3 · see citing works
The thyroid-liver axis in MASLD: From metabolic control to clinical translation
Chouik, Y., Caussy, C., & Tacke, F. (2026) · Med · doi:10.1016/j.medj.2026.101173 · Cited by 3 · see citing works
Shang, S., Wan, Q., Chen, F., & Hu, J. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149739 · Cited by 3 · see citing works
Studies on glycogen storage disease type 1a animal models: a brief perspective
Petrova, I. O., & Smirnikhina, S. (2022) · Transgenic Research · doi:10.1007/s11248-022-00325-7 · Cited by 3 · see citing works
Current and Emerging Treatments for Non-alcoholic Steatohepatitis
Horn, C. L., Ta, A. C., & Gunn, N. (2020) · Current Hepatology Reports · doi:10.1007/s11901-020-00540-y · Cited by 3 · see citing works
Cui, H., Lin, D., Dang, Q., & Bai, X. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.3c02151 · Cited by 2 · see citing works
Yang, Y., Xiao, J., Qiu, W., & Jiang, L. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2276-7973 · Cited by 2 · see citing works
Goswami, S., & Khare, V. R. (2024) · Thyroid Research and Practice · doi:10.4103/trp.trp_22_23 · Cited by 1 · see citing works
Diabetes and Obesity as Catalysts in MASH Progression: Mechanisms and Emerging Therapies
Munda, B., Bhutia, C., Deepti, & Khatri, M. (2026) · Letters in Applied NanoBioScience · doi:10.33263/lianbs151.011
Thyroid-Liver Axis: Mechanistic Insights and Clinical Implications
Parveen, N., Chittawar, S., Khandelwal, D., & Aggarwal, S. (2026) · Cureus · doi:10.7759/cureus.110637
Lipotoxicity in MAFLD/MASH: cellular mechanisms and targetable nodes
Tawai, J., Zhou, K., & Xiong, J. (2026) · Targetome · doi:10.48130/targetome-0026-0047
- Authors
- Zhou, J., Waskowicz, L. R., Lim, A., Liao, X.-H., Lian, B., Masamune, H., Refetoff, S., Tran, B., Koeberl, D. D., & Yen, P. M.
- Affiliations
- Duke-NUS Medical School (SG)
- Duke Medical Center (US)
- University of Chicago (US)
- Viking Therapeutics (United States) (US)
- Duke University (US)
- National University of Singapore (SG)
- Corresponding author
- Koeberl, Dwight D.
- Yen, Paul M.
- ORCID
- Venue
- Thyroid®
- Publisher
- SAGE Publications
- Published
- 2019-08
- Volume
- 29
- Issue
- 8
- Pages
- 1158-1167
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- PMC
- PMC6707038
- OpenAlex
- W2962815903
- Cited by
- 60
- References
- 44
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 11 · 2023: 11 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 2
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Thyroid (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK105434, R01DK015070)
- Topics
- Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- glycogen storage disease type Ia, von Gierke disease, hepatic steatosis, thyroid hormone receptor beta agonist, autophagy, mitochondrial biogenesis, fatty acid beta-oxidation, AMPK/mTOR signaling, glucose-6-phosphatase deficiency, non-alcoholic fatty liver disease, FGF21, CPT1A
- MeSH terms
- Animals, Autophagy, Organelle Biogenesis, Disease Models, Animal, Fatty Acids, Fatty Liver, Glucose-6-Phosphatase, Glycogen Storage Disease Type I, Glycogen, Liver, Mitochondria, Liver, Oxidation-Reduction, Triglycerides, Mice, Knockout, Thyroid Hormone Receptors beta, Mice, Organophosphonates
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
