Cited by 93Liver Disease Diagnosis and TreatmentThyroid Disorders and TreatmentsAlcohol Consumption and Health Effects

NAFLD and thyroid function: pathophysiological and therapeutic considerations

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Hatziagelaki, Erifili, Paschou, Stavroula A., Schön, Martin, Psaltopoulou, Theodora, Roden, Michael·2022·Trends in Endocrinology & Metabolism

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic, but also extrahepatic, complications. Thyroid hormones are master regulators of energy and lipid homeostasis, and the presence of abnormal thyroid function in NAFLD suggests pathogenic relationships. Specifically, persons with hypothyroidism feature dyslipidemia and lower hepatic β-oxidation, which favors accumulation of triglycerides and lipotoxins, insulin resistance, and subsequently de novo lipogenesis. Recent studies indicate that liver-specific thyroid hormone receptor β agonists are effective for the treatment of NAFLD, likely due to improved lipid homeostasis and mitochondrial respiration, which, in turn, may contribute to a reduced risk of NAFLD progression. Taken together, the possible coexistence of thyroid disease and NAFLD calls for increased awareness and optimized strategies for mutual screening and management.

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Crossref · 10.1016/j.tem.2022.08.001

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Authors
Hatziagelaki, E., Paschou, S. A., Schön, M., Psaltopoulou, T., & Roden, M.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • Deutsches Diabetes-Zentrum e.V. (DE)
  • Düsseldorf University Hospital (DE)
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2022-11
Volume
33
Issue
11
Pages
755-768
ISSN
1043-2760 (ISSN-L)
OpenAlex
W4297216245
Cited by
93
References
113
Citations by year
2026: 17 · 2025: 41 · 2024: 25 · 2023: 8 · 2022: 2
FWCI
3.01
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
German Federal Ministry of Health
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
non-alcoholic fatty liver disease, thyroid function, hypothyroidism, thyroid hormone receptor beta agonist, lipid homeostasis, hepatic beta-oxidation, insulin resistance, de novo lipogenesis, dyslipidemia, mitochondrial respiration, NAFLD screening
MeSH terms
Humans, Liver, Thyroid Gland, Triglycerides, Thyroid Hormone Receptors beta, Lipogenesis, Non-alcoholic Fatty Liver Disease

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