The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring
Open accessAbstract
SIGNIFICANCE: Wound healing is an intricate biological process in which the skin, or any other tissue, repairs itself after injury. Normal wound healing relies on the appropriate levels of cytokines and growth factors to ensure that cellular responses are mediated in a coordinated manner. Among the many growth factors studied in the context of wound healing, transforming growth factor beta (TGF-β) is thought to have the broadest spectrum of effects. RECENT ADVANCES: Many of the molecular mechanisms underlying the TGF-β/Smad signaling pathway have been elucidated, and the role of TGF-β in wound healing has been well characterized. Targeting the TGF-β signaling pathway using therapeutic agents to improve wound healing and/or reduce scarring has been successful in pre-clinical studies. CRITICAL ISSUES: through mechanisms that have not been fully elucidated. The challenge of translating preclinical studies targeting the TGF-β signaling pathway to a clinical setting may require more extensive preclinical research using animal models that more closely mimic wound healing and scarring in humans, and taking into account the spatial, temporal, and cell-type-specific aspects of TGF-β isoform expression and function. FUTURE DIRECTIONS: Understanding the differences in TGF-β isoform signaling at the molecular level and identification of novel components of the TGF-β signaling pathway that critically regulate wound healing may lead to the discovery of potential therapeutic targets for treatment of impaired wound healing and pathological scarring.
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Cites
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Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,857
PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
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Mechanism of activation of the TGF-β receptor
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The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Cellular and extracellular matrix modulation of corneal stromal opacity
Torricelli, A. A. M., & Wilson, S. E. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.09.013 · Cited by 124
Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
Hofmann, E., Fink, J., Pignet, A.-L., Schwarz, A., Schellnegger, M., Nischwitz, S. P., Holzer-Geissler, J. C. J., Kamolz, L.-P., & Kotzbeck, P. (2023) · Biomedicines · doi:10.3390/biomedicines11041056 · Cited by 104
CD109, a master regulator of inflammatory responses
Batal, A., Garousi, S., Finnson, K. W., & Philip, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1505008 · Cited by 21
Self-citation
Metadata
- Authors
- Finnson, K. W., McLean, S., Di Guglielmo, G. M., & Philip, A.
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2013-06
- Volume
- 2
- Issue
- 5
- Pages
- 195-214
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- OpenAlex
- W2057538896
- Cited by
- 300
- References
- 165
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
