Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

3D bioprinting of tissues and organs

Murphy, S. V., & Atala, A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2958 · Cited by 7,034 · see citing works

In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

Liang, C.-C., Park, A. Y., & Guan, J.-L. (2007) · Nature Protocols · doi:10.1038/nprot.2007.30 · Cited by 4,696 · see citing works

Wound repair and regeneration: Mechanisms, signaling, and translation

Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works

The third dimension bridges the gap between cell culture and live tissue

Pampaloni, F., Reynaud, E. G., & Stelzer, E. H. K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2236 · Cited by 2,817 · see citing works

Wound Healing: A Cellular Perspective.

Rodrigues, M., Kosaric, N., Bonham, C., & Gurtner, G. (2019) · Physiological Reviews · doi:10.1152/physrev.00067.2017 · Cited by 2,752 · see citing works

Adipose-derived stem cells for regenerative medicine

Gimble, J. M., Katz, A. J., & Bunnell, B. A. (2007) · Circulation Research · doi:10.1161/01.res.0000265074.83288.09 · Cited by 2,332 · see citing works

Wound Repair and Regeneration

Reinke, J. M., & Sorg, H. (2012) · European Surgical Research · doi:10.1159/000339613 · Cited by 1,898 · see citing works

Wound healing: cellular mechanisms and pathological outcomes

Wilkinson, H. N., & Hardman, M. J. (2020) · Open Biology · doi:10.1098/rsob.200223 · Cited by 1,886 · see citing works

Three-dimensional in vitro cell culture models in drug discovery and drug repositioning

Langhans, S. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00006 · Cited by 1,522 · see citing works

Inflammation in Chronic Wounds

Zhao, R., Liang, H. H., Clarke, E., Jackson, C., & Xue, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122085 · Cited by 1,201 · see citing works

In vitro cell migration and invasion assays

Kramer, N., Walzl, A., Unger, C., Rosner, M., Krupitza, G., Hengstschläger, M., & Dolznig, H. (2013) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.08.001 · Cited by 1,170 · see citing works

Progress in 3D bioprinting technology for tissue/organ regenerative engineering

Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119536 · Cited by 1,156 · see citing works

The pig as a model for human wound healing

Sullivan, T. P., Eaglstein, W. H., Davis, S. C., & Mertz, P. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00066.x · Cited by 1,091 · see citing works

Three-Dimensional Cell Culture: A Breakthrough in Vivo

Antoni, D., Burckel, H., Josset, E., & Noël, G. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16035517 · Cited by 998 · see citing works

Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis

Ogawa, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030606 · Cited by 985 · see citing works

Immunology of Acute and Chronic Wound Healing

Raziyeva, K., Kim, Y., Zharkinbekov, Z., Kassymbek, K., Jimi, S., & Saparov, A. (2021) · Biomolecules · doi:10.3390/biom11050700 · Cited by 967 · see citing works

Micromotion of mammalian cells measured electrically.

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Wound healing, fibroblast heterogeneity, and fibrosis

Talbott, H. E., Mascharak, S., Griffin, M., Wan, D. C., & Longaker, M. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.07.006 · Cited by 745 · see citing works

An introduction to the wound healing assay using live-cell microscopy

Jonkman, J. E. N., Cathcart, J. A., Xu, F., Bartolini, M. E., Amon, J. E., Stevens, K. M., & Colarusso, P. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.36224 · Cited by 735 · see citing works

Skin tissue engineering — In vivo and in vitro applications

Groeber, F., Holeiter, M., Hampel, M., Hinderer, S., & Schenke‐Layland, K. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.005 · Cited by 633 · see citing works

Generation of induced pluripotent stem cells from human blood

Loh, Y.-H., Agarwal, S., Park, I.-H., Urbach, A., Huo, H., Heffner, G. C., Kim, K., Miller, J. D., Ng, K., & Daley, G. Q. (2009) · Blood · doi:10.1182/blood-2009-02-204800 · Cited by 626 · see citing works

The immunology of the porcine skin and its value as a model for human skin

Summerfield, A., Meurens, F., & Ricklin, M. E. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2014.10.023 · Cited by 551 · see citing works

Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity

Nunan, R., Harding, K. G., & Martin, P. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.016782 · Cited by 542 · see citing works

Animal models in burn research

Abdullahi, A., Amini‐Nik, S., & Jeschke, M. G. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1612-5 · Cited by 470 · see citing works

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

Szabowski, A., Maas‐Szabowski, N., Andrecht, S., Kolbus, A., Schorpp‐Kistner, M., Fusenig, N. E., & Angel, P. E. (2000) · Cell · doi:10.1016/s0092-8674(00)00178-1 · Cited by 423 · see citing works

Electrical wound-healing assay for cells in vitro

Keese, C. R., Wegener, J., Walker, S. R., & Giæver, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307588100 · Cited by 423 · see citing works

Surgical Approaches to Create Murine Models of Human Wound Healing

Wong, V., Sorkin, M., Glotzbach, J. P., Longaker, M. T., & Gurtner, G. C. (2010) · BioMed Research International · doi:10.1155/2011/969618 · Cited by 418 · see citing works

Treatment of Inflamed Hypertrophic Scars Using Intralesional 5-FU

FITZPATRICK, R. E. (1999) · Dermatologic Surgery · doi:10.1046/j.1524-4725.1999.08165.x · Cited by 373 · see citing works

The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models

Limandjaja, G. C., Niessen, F. B., Scheper, R. J., & Gibbs, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00360 · Cited by 356 · see citing works

Engineering cellular microenvironments to improve cell-based drug testing

Bhadriraju, K., & Chen, C. S. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02273-0 · Cited by 355 · see citing works

The use of skin models in drug development

Mathes, S. H., Ruffner, H., & Graf‐Hausner, U. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.006 · Cited by 321 · see citing works

Metabolic orchestration of the wound healing response

Eming, S. A., Murray, P. J., & Pearce, E. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.017 · Cited by 319 · see citing works

Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents

Sun, T. L., Jackson, S. J., Haycock, J. W., & MacNeil, S. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.12.021 · Cited by 309 · see citing works

Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism

Maas‐Szabowski, N., Shimotoyodome, A., & Fusenig, N. E. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1843 · Cited by 302 · see citing works

Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring

Finnson, K. W., McLean, S., Guglielmo, G. M. D., & Philip, A. (2013) · Advances in Wound Care · doi:10.1089/wound.2013.0429 · Cited by 302 · see citing works

Animal models for percutaneous absorption

Jung, E., & Maïbach, H. I. (2014) · Journal of Applied Toxicology · doi:10.1002/jat.3004 · Cited by 293 · see citing works

3D Cell Printing of Perfusable Vascularized Human Skin Equivalent Composed of Epidermis, Dermis, and Hypodermis for Better Structural Recapitulation of Native Skin

Kim, B. S., Gao, G., Kim, J. Y., & Cho, D. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801019 · Cited by 292 · see citing works

Age-Related Aspects of Cutaneous Wound Healing: A Mini-Review

Sgonc, R., & Gruber, J. (2013) · Gerontology · doi:10.1159/000342344 · Cited by 288 · see citing works

Abnormal wound healing: keloids

Robles, D. T., & Berg, D. (2007) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2006.09.009 · Cited by 281 · see citing works

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

Ataç, B., Wagner, I. P., Horland, R., Lauster, R., Marx, U., Tonevitsky, A., Azar, R. P., & Lindner, G. (2013) · Lab on a Chip · doi:10.1039/c3lc50227a · Cited by 273 · see citing works

Skin Bioprinting: Impending Reality or Fantasy?

Ng, W. L., Wang, S., Yeong, W. Y., & Naing, M. W. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.04.006 · Cited by 251 · see citing works

Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC‐Derived Endothelial Cells

Abaci, H. E., Guo, Z., Coffman, A., Gillette, B. M., Lee, W.-H., Sia, S. K., & Christiano, A. M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500936 · Cited by 248 · see citing works

Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts

Maas‐Szabowski, N., Stark, H., & Fusenig, N. E. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00987.x · Cited by 232 · see citing works

IFATS Collection: Using Human Adipose-Derived Stem/Stromal Cells for the Production of New Skin Substitutes

Trottier, V., Marceau-Fortier, G., Germain, L., Vincent, C., & Fradette, J. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0031 · Cited by 231 · see citing works

Fibroblast Dysfunction Is a Key Factor in the Non-Healing of Chronic Venous Leg Ulcers

Wall, I. B., Moseley, R., Baird, D. M., Kipling, D., Giles, P., Laffafian, I., Price, P. E., Thomas, D. W., & Stephens, P. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.114 · Cited by 226 · see citing works

Deep dermal fibroblasts contribute to hypertrophic scarring

Wang, J., Dodd, C. M., Shankowsky, H. A., Scott, P. G., & Tredget, E. E. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.101 · Cited by 218 · see citing works

The Impact of Prolonged Inflammation on Wound Healing

Holzer-Geissler, J. C. J., Schwingenschuh, S., Zacharias, M., Einsiedler, J., Kainz, S., Reisenegger, P., Holeček, C., Hofmann, E., Wolff‐Winiski, B., Fahrngruber, H., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10040856 · Cited by 216 · see citing works

Efficacy and Safety of Intralesional 5-Fluorouracil in the Treatment of Keloids

Gupta, S., & Kalra, A. (2002) · Dermatology · doi:10.1159/000051830 · Cited by 210 · see citing works

3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function

Niehues, H., Bouwstra, J. A., El Ghalbzouri, A., Brandner, J. M., Zeeuwen, P. L. J. M., & van den Bogaard, E. H. (2018) · Experimental Dermatology · doi:10.1111/exd.13531 · Cited by 210 · see citing works

Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro

Diegelmann, R. F., Cohen, I. K., & McCoy, B. J. (1979) · Journal of Cellular Physiology · doi:10.1002/jcp.1040980210 · Cited by 202 · see citing works

Models for use in wound healing research: A survey focusing on in vitro and in vivo adult soft tissue

Gottrup, F., Ågren, M. S., & Karlsmark, T. (2000) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2000.00083.x · Cited by 199 · see citing works

Mechanisms of wound reepithelialization: hints from a tissue‐engineered reconstructed skin to long‐standing questions

Laplante, A., Germain, L., Auger, F. A., & Moulin, V. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0250com · Cited by 199 · see citing works

A Simplified Method for Quantifying Cell Migration/Wound Healing in 96-Well Plates

Yue, P. Y., Leung, E. P. Y., Mak, N. K., & Wong, R. N. (2010) · SLAS DISCOVERY · doi:10.1177/1087057110361772 · Cited by 196 · see citing works

Modulation of Collagen Synthesis by Transforming Growth Factor-β in Keloid and Hypertrophic Scar Fibroblasts

Younai, S. S., Nichter, L. S., Wellisz, T., Reinisch, J. F., Nimni, M. E., & Tuan, T. (1994) · Annals of Plastic Surgery · doi:10.1097/00000637-199408000-00005 · Cited by 193 · see citing works

Hyperglycaemic conditions decrease cultured keratinocyte mobility: implications for impaired wound healing in patients with diabetes

Lan, C.-C. E., Liu, I.-H., Fang, A.-H., Wen, C.-H., & Wu, C.-S. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08789.x · Cited by 183 · see citing works

A narrative review of the epidemiology and economics of chronic wounds

Graves, N., Phillips, C. J., & Harding, K. G. (2021) · British Journal of Dermatology · doi:10.1111/bjd.20692 · Cited by 177 · see citing works

Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars

Darougheh, A., Asilian, A., & Shariati, F. A. (2008) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2007.02631.x · Cited by 175 · see citing works

Mesenchymal Stem Cells: Molecular Targets for Tissue Engineering

Satija, N. K., Gurudutta, G. U., Sharma, S., Afrin, F., Gupta, P., Verma, Y. K., Singh, V. K., & Tripathi, R. (2007) · Stem Cells and Development · doi:10.1089/scd.2006.9998 · Cited by 171 · see citing works

Fibroblasts facilitate re-epithelialization in wounded human skin equivalents

Ghalbzouri, A. E., Hensbergen, P. J., Gibbs, S., Kempenaar, J. A., van der Schors, R. C., & Ponec, M. (2003) · Laboratory Investigation · doi:10.1038/labinvest.3700014 · Cited by 162 · see citing works

Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing.

Babu, M., Diegelmann, R. F., & Oliver, N. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1642 · Cited by 159 · see citing works

Porcine wound models for skin substitution and burn treatment

Middelkoop, E., van den Bogaerdt, A. J., Lamme, E. N., Hoekstra, M. J., Brandsma, K., & Ulrich, M. M. W. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00502-7 · Cited by 153 · see citing works

In vitro wound healing assays – state of the art

Stamm, A., Reimers, K., Strauß, S., Vogt, P. M., Scheper, T. H., & Pepelanova, I. (2016) · BioNanoMaterials · doi:10.1515/bnm-2016-0002 · Cited by 153 · see citing works

Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective

van den Broek, L. J., Limandjaja, G. C., Niessen, F. B., & Gibbs, S. (2014) · Experimental Dermatology · doi:10.1111/exd.12419 · Cited by 148 · see citing works

In vitro 3D Full‐Thickness Skin‐Equivalent Tissue Model Using Silk and Collagen Biomaterials

Bellas, E., Seiberg, M., Garlick, J. A., & Kaplan, D. L. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201200262 · Cited by 148 · see citing works

Role of Macrophages in Wound HealingPreprint

Willenborg, S., Injarabian, L., & Eming, S. A. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041216 · Cited by 147 · see citing works

Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors

Moulin, V., Larochelle, S., Langlois, C., Thibault, I., Lopez‐Vallé, C. A., & Roy, M. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.10415 · Cited by 144 · see citing works

Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars

Bellemare, J., Roberge, C. J., Bergeron, D., Lopez‐Vallé, C. A., Roy, M., & Moulin, V. J. (2005) · The Journal of Pathology · doi:10.1002/path.1737 · Cited by 135 · see citing works

Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner

Lim, I. J., Phan, T. T., Bay, B., Qi, R. Z., Huynh, H. T., Tan, W. T. L., Lee, S.-T., & Longaker, M. T. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00555.2001 · Cited by 135 · see citing works

Atlas of Small Animal Wound Management and Reconstructive Surgery

Pavletic, M. M. (2018) · Wiley eBooks · doi:10.1002/9781119267539 · Cited by 133 · see citing works

Animal models of skin disease for drug discovery

Avci, P., Sadasivam, M., Gupta, A., De Melo, W. C., Huang, Y.-Y., Yin, R., Chandran, R., Kumar, R., Otufowora, A., Nyame, T., et al. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.761202 · Cited by 130 · see citing works

Keratinocytes Promote Proliferation and Inhibit Apoptosis of the Underlying Fibroblasts: An Important Role in the Pathogenesis of Keloid

Funayama, E., Chodon, T., Oyama, A., & Sugihara, T. (2003) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2003.12572.x · Cited by 129 · see citing works

Is There an Ideal Animal Model to Study Hypertrophic Scarring?

Ramos, M. L. C., Gragnani, A., & Ferreira, L. M. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181667557 · Cited by 128 · see citing works

The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research fields

Naldaiz‐Gastesi, N., Bahri, O. A., de Munaín, A. L., McCullagh, K. J. A., & Izeta, A. (2018) · Journal of Anatomy · doi:10.1111/joa.12840 · Cited by 121 · see citing works

Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections – a randomized controlled trial

Hietanen, K., Järvinen, T. A. H., Huhtala, H., Tolonen, T., Kuokkanen, H., & Kaartinen, I. (2018) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2018.05.052 · Cited by 121 · see citing works

Development of a Three-Dimensional Human Skin Equivalent Wound Model for Investigating Novel Wound Healing Therapies

Xie, Y., Rizzi, S. C., Dawson, R., Lynam, E. C., Richards, S., Leavesley, D. I., & Upton, Z. (2010) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2009.0725 · Cited by 115 · see citing works

A first vascularized skin equivalent for as an alternative to animal experimentation

Groeber, F. (2016) · ALTEX · doi:10.14573/altex.1604041 · Cited by 113 · see citing works

Investigation of the Influence of Keloid-Derived Keratinocytes on Fibroblast Growth and Proliferation in Vitro

Lim, I. J., Phan, T. T., Song, C., Tan, W. T. L., & Longaker, M. T. (2001) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200103000-00022 · Cited by 111 · see citing works

Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering

Huber, B., Borchers, K., Tovar, G. E. M., & Kluger, P. J. (2015) · Journal of Biomaterials Applications · doi:10.1177/0885328215587450 · Cited by 111 · see citing works

The development of a 3D immunocompetent model of human skin

Chau, D. Y. S., Johnson, C., MacNeil, S., Haycock, J. W., & Ghaemmaghami, A. M. (2013) · Biofabrication · doi:10.1088/1758-5082/5/3/035011 · Cited by 110 · see citing works

Intralesional 5‐fluorouracil in the treatment of keloid scars

Apikian, M., & Goodman, G. J. (2004) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.2004.00072.x · Cited by 108 · see citing works

Epidermal Regulation of Dermal Fibroblast Activity

Garner, W. L. (1998) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199807000-00021 · Cited by 107 · see citing works

Keloid‐derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology

Hahn, J. M., Glaser, K., McFarland, K. L., Aronow, B. J., Boyce, S. T., & Supp, D. M. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12060 · Cited by 107 · see citing works

Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial

Khalid, A., Mehrose, M. Y., Saleem, M., Yousaf, M. A., Mujahid, A. M., Rehman, S. U., Ahmad, S., & Tarar, M. N. (2018) · Burns · doi:10.1016/j.burns.2018.08.011 · Cited by 107 · see citing works

Increased Proliferation in Keloid Fibroblasts Woundedin Vitro

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Three-Dimensional Human Tissue Models That Incorporate Diabetic Foot Ulcer-Derived Fibroblasts Mimic In Vivo Features of Chronic Wounds

Maione, A. G., Brudno, Y., Stojadinović, O., Park, L. K., Smith, A., Tellechea, A., Leal, E. C., Kearney, C. J., Veves, A., Tomic‐Canic, M., et al. (2014) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2014.0414 · Cited by 103 · see citing works

3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components

Yucha, S. E. V., Tamamoto, K. A., Nguyen, H., Abbott, R. D., Cairns, D. M., & Kaplan, D. L. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.044 · Cited by 101 · see citing works

Effects of Solar Ultraviolet Radiation on Engineered Human Skin Equivalent Containing Both Langerhans Cells and Dermal Dendritic Cells

Béchetoille, N., Dezutter‐Dambuyant, C., Damour, O., André, V., Orly, I., & Perrier, É. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0405 · Cited by 100 · see citing works

Technical Advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration

Ouwehand, K., Spiekstra, S. W., Waaijman, T., Scheper, R. J., de Gruijl, T. D., & Gibbs, S. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0610374 · Cited by 94 · see citing works

Burns as a model of SIRS

Dahiya, P. (2009) · Frontiers in bioscience · doi:10.2741/3580 · Cited by 93 · see citing works

Histogenesis of Experimentally Produced Keloids

Mancini, R. E., & QUAIFE, J. V. (1962) · Journal of Investigative Dermatology · doi:10.1038/jid.1962.29 · Cited by 87 · see citing works

Current Therapeutic Approach to Hypertrophic Scars

Mokoš, Z. B., Balić, A., Grgurević, L., Dumić-Čule, I., Kostović, K., Čeović, R., & Marinović, B. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00083 · Cited by 87 · see citing works

A Primary Protocol for the Management of Ear Keloids: Results of Excision Combined with Intraoperative and Postoperative Steroid Injections

Rosen, D. J., Patel, M., Freeman, K. D., & Weiss, P. R. (2007) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000279373.25099.2a · Cited by 86 · see citing works

Methods to study differences in cell mobility during skin wound healing in vitro

Monsuur, H. N., Boink, M. A., Weijers, E. M., Roffel, S., Breetveld, M., Gefen, A., van den Broek, L. J., & Gibbs, S. (2016) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2016.01.040 · Cited by 85 · see citing works

Wounds: Biology, Pathology, and Management

Lorenz, H. P., & Longaker, M. T. (2008) · Springer eBooks · doi:10.1007/978-0-387-68113-9_10 · Cited by 84 · see citing works

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Current Insights and Future Directions in Scar Management and Skin Regeneration

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Biological Models for Evaluating Hydrogel-Based Formulations in Wound Healing

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A systematic review and meta-analysis to investigate the effectiveness of exosome for diabetic wounds

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Scar-reducing ionically conductive chitosan bandage: Combining ionic and electrical stimulation for optimal wound healing

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Impact of donor pool size on the variability of platelet lysate-derived extracellular vesicles for regenerative medicine

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Human Skin Fibroblasts as an In Vitro Model Illustrating Changes in Collagen Levels and Skin Cell Migration Under the Influence of Selected Plant Hormones

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Penicillamine-based chiral ZnO nanoparticles: A dual mechanism for infected wound healing via antibacterial activity and immune regulation

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Pressure Ulcers and Nutrients: From Established Evidence to Gaps in Knowledge

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Safety and effectiveness of an antiseptic wound cleansing and irrigation solution containing polyhexamethylene biguanide

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Exploring Synergistic Effects of Bioprinted Extracellular Vesicles for Skin Regeneration

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Understanding the ideal wound healing mechanistic behavior using in silico modelling perspectives: A review

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Anatomy of a bioengineered human pigmented skin equivalent to provide fundamental insights into skin tone melanin dynamics

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Innervated Coculture Device to Model Peripheral Nerve-Mediated Fibroblast Activation

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Targeted Antibacterial Endolysin to Treat Infected Wounds on 3D Full-Thickness Skin Model: XZ.700 Efficacy

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A standardized in vitro bioengineered skin for penetrating wound modeling

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Effect of Betulin Colloidal Particles on Proliferation and Cytokine Secretion of Human Skin Fibroblasts

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A dermis-on-a-chip model for compound screening

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Development of Antimicrobial Wound Healing Hydrogels Based on the Microbial Polysaccharide Pullulan

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Advancing preclinical research with reconstructed in vitro skin models mimicking non-healing wounds

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Inhibition of Th2 Differentiation Accelerates Chronic Wound Healing by Facilitating Lymphangiogenesis

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Comparative effectiveness of plant-derived compounds in keloid management: a review

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Harnessing traditional chinese medicine for wound healing and modern wound models: An overview

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Establishing Primary and Stable Cell Lines from Frozen Wing Biopsies for Cellular, Physiological, and Genetic Studies in Bats

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Effects of silver nanoparticle and low-level laser on the immune response and healing of albino mice skin wounds

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Janus nanofiber membrane films loading with bioactive calcium silicate for the promotion of burn wound healing

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Evaluating pomegranate seed oil for potential topical applications: safety, anti-inflammatory activity and wound healing in skin cell models

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Therapeutic value of mesenchymal stem cell-derived extracellular vesicles in hypertrophic and keloid scars: a systematic review and meta-analysis

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Melt electrowriting scaffolds for investigating Schwann cell-mediated modulation of vascular network formation

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Wound Closure Promotion by Leucine-Based Pseudo-Proteins: An In Vitro Study

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The role of Latin America medicinal plants in wound healing

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3D Printing of Photocrosslinked Alginate Dialdehyde‐Gelatin Hydrogels Reinforced with Cobalt‐Containing Mesoporous Bioactive Glass Nanoparticles for Developing Skin Wound Dressings

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Lipid analysis of human primary dermal fibroblasts and epidermal keratinocytes after near-infrared exposure using mass spectrometry imaging

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Laminaria japonica polysaccharide nano‑silver film with synergistic antibiosis for wound healing

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Topical Administration of Vitamin D2 Combined with Colloidal Silver Nanoparticles Promotes Wound Repair and Protection Against Skin Irritation and UVB Irradiation in 3D Reconstructed Human Skin Models

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Properties of chitosan-gelatine based, aloe vera and propolis added biofunctional wound dressing material

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A programmable platform for probing cell migration and proliferation

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Features of apoptotic and proliferative processes in experimental infected radiation-induced skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma

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Automated In Vitro Wound Healing AssayPreprint

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An In Vitro Artificial Wound Slough–Biofilm Model Developed for Evaluating a Novel Antibiofilm Technology

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Challenges in the translation of chronic wound therapeutics from bench to bedside

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From Fins to Furs: Unlocking the Therapeutic Potential of Animal-derived Bioactives for Wound Care

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Development of pathological skin models: from conventional techniques to 3D bioprinting

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Exploring traditional Japanese herbal ointments for wound healing: A wide diversity of practices, metabolites, and effects

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Machine learning-based investigation of the relationship between plasma emission spectra and biological responses *

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Engineering the Healing Process: Advanced In Vitro Wound Models and Technologies

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Temporal In Vitro Models of Skin Wound Healing Components: A Cell-Specific Framework for Acute and Chronic Repair Mechanisms

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Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge Model for Human Skin and its Diseases

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Vegetable Butter-Based Nanocarriers: Do Nanoparticulation and Quercetin Loading Modulate In vitro Cellular Effects Involved in Wound Healing?

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Developing Three-Dimensional (3D) Skin Models to Study the Interaction Between the Skin Microbiome and Immune Cells in Chronic Wounds

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Assessment of Skin Wound Healing Potentiality of the Topical Prosopis Juliflora Leaf Extract Vs. Sulphadiazine in Male Albino Rat; Histological and Immunohistochemical Study

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The determination of fibroblast and keratinocyte death types after their transplantation into γ-irradiated porous scaffold in vitro

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In vitro skin models. Challenges and Future Steps

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Fisiología de la cicatrización de las heridas cutáneas: análisis centrado en el papel de la respuesta inmunitaria innata y las aplicaciones terapéuticas

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Wound Healing Potential of a Novel Sedum Species: S. album Murales

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Exploring New Horizons in Wound Healing: A Comprehensive Analysis

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Ex Vivo Human Skin Model to Study Immediate and Early Local Responses to External Stimuli

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Efecto en la cicatrización de heridas inducido por proteínas de Mangifera indica var. manila en fibroblastos humanos

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New Methodological Approach to Follow the Re‐Epithelialisation Phase in the Wound Healing Process on a 3D Full Thickness Skin Model

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EXPERIMENTAL ANIMAL MODELS IN WOUND HEALING RESEARCH: MECHANISMS, APPLICATIONS, AND LIMITATIONS

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Mixing vs. layering: How to make an in vivo like skin model

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Wound Healing Composite Nanofiber Materials: Polymer Nanofibers Reinforced with Nature-derived Components

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Preclinical Models for Wound Healing and Repair Studies

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A Sandwich-Structured Drug-Loaded Polyester Dressing with Unidirectional Liquid Transport Capability for Exudate Management and Wound Healing

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Open Pilonidal Excision as a Translational Human Model for Wound Healing and Skin Regeneration Research

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Three-dimensional bioprinted platforms for disease management: cancer and chronic wounds

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Soluble CD83 Accelerates Wound Healing and Attenuates Inflammatory Responses Induced by Chronic Wound Fluid in a Human 3D in Vitro Wound Healing Model

Hollard, C., Peckert-Maier, K., Ronicke, M., Sinner, P., Stritt, F., Spöttl, T., Mühl-Zürbes, P., Wirtz, S., Erfurt-Berge, C. S., Steinkasserer, A., et al. (2026) · Wound Repair and Regeneration · doi:10.1111/wrr.70158

A Cross-tissue Temporal Multi-omics Atlas Reveals the Molecular Architecture of Pressure InjuryPreprint

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Advanced functional electrospun membranes as dressings for diabetic wound healing

Di, T., Yang, Q., Wen, Y., Yang, S., Yang, X., Chen, P., & Zhang, M. (2026) · Applied Materials Today · doi:10.1016/j.apmt.2026.103303

Fascia explants enable real-time dynamic studies of wound fibroblast ancestry in living tissues

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Combined Effect: Development and Physical/Biological Assessment of PVA/Chitosan Hydrogels Containing rhTGF-β1-Loaded PLGA Nanoparticles

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Application of Smart Hydrogels in Diabetic Wound Management: Microenvironment-Responsive Strategies and Clinical Translation Challenges

Li, C.-R., Wang, K. Z., Xia, S., Hu, P., Liu, H., Liu, C., Wang, S. K., 蒋, 先., & Song, H. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6c00731

Reversing diabetic wound stagnation: macrophage polarization dysregulation as a therapeutic linchpin from pathogenesis to precision interventions

Liu, S., Cai, C., Liu, H., Zhao, Z., Han, C., Wang, X., & Wang, Y. (2026) · Burns & Trauma · doi:10.1093/burnst/tkag044

Nanoparticle-driven macrophage polarization as a therapeutic strategy for chronic diabetic wounds

Yanhui, L., & Wb, Z. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117161

Antioxidant MOF Nanozyme‐Engineered Periodontal Ligament Stem Cells Promote Diabetic Wound Healing

Liu, X., Dong, Q., Sun, Y., Wu, J., Zhao, X., Chu, C., Li, T., Chao, D., & Ding, G. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71523

Engineering a reproducible 3D wound model with defined macrophage polarization and partial-thickness mechanical injuryPreprint

Suppiyar, Q., Ibing, W., Garabet, W., Wagenhäuser, M. U., Twarock, S., Schelzig, H., & Rembe, J. (2026) · Research Square · doi:10.21203/rs.3.rs-10548292/v1

In vitro pre-vascularized model of the human skin based on collagen hydrogel reinforced by fibrin-coated nanofibrous membrane

Tomšů, J., Doubková, M., Brož, A., Blanquer, A., Hadraba, D., Trávníčková, M., Šuca, H., Šupová, M., Jenčová, V., & Bacakova, L. (2026) · Journal of Tissue Engineering · doi:10.1177/20417314261478553

The pursuit of perfect healing: deciphering the code of scarless healing in regenerative medicine

Ritu, F. A., Duan, R., Ullah, N., Fahad, A. A., Siddiqui, A., Touqeer, M., & Huang, D. (2026) · Frontiers of Materials Science · doi:10.1007/s11706-026-0782-z

Advances in the application of in vitro skin wound models for disease modeling and therapeutic development in diabetes and related disorders

Li, Z., Liu, X., Zhang, Z., Zhang, J., Si, N., Gu, Z., Chen, Z., & Yin, N. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.181617

Wound healing and cutaneous scarring models of the human skin

Ashrafi, M. H., Hague, A. G., Baguneid, M. S., Alonso-Rasgado, T. A., & Bayat, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810545-0.00009-7 · Cited by 10 · see citing works

Preclinical models for wound-healing studies

Pastar, I., Liang, L., Sawaya, A. P., Wikramanayake, T. C., Glinos, G. D., Drakulich, S., Chen, V., Stojadinović, O., Davis, S. C., & Tomic‐Canic, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810545-0.00010-3 · Cited by 39 · see citing works

Non‐animal models of wound healing in cutaneous repair: In silico, in vitro, ex vivo, and in vivo models of wounds and scars in human skin

Ud‐Din, S., & Bayat, A. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12513 · Cited by 127 · see citing works

Chronic Wound Healing Models

Flynn, K., Mahmoud, N. N., Sharifi, S., Gould, L. J., & Mahmoudi, M. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00030 · Cited by 101 · see citing works

Comparative wound healing—Are the small animal veterinarian's clinical patients an improved translational model for human wound healing research?

Volk, S. W., & Bohling, M. W. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12049 · Cited by 93 · see citing works