The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair
Open accessAbstract
Significance: Angiogenesis, the growth of new blood vessels from existing vessels, is an important aspect of the repair process. Restoration of blood flow to damaged tissues provides oxygen and nutrients required to support the growth and function of reparative cells. Vascular endothelial growth factor (VEGF) is one of the most potent proangiogenic growth factors in the skin, and the amount of VEGF present in a wound can significantly impact healing. Recent Advances: The activity of VEGF was once considered to be specific for endothelial cells lining the inside of blood vessels, partly because VEGF receptor (VEGFR) expression was believed to be restricted to endothelial cells. It is now known, however, that VEGFRs can be expressed by a variety of other cell types involved in wound repair. For example, keratinocytes and macrophages, which both carry out important functions during wound healing, express VEGFRs and are capable of responding directly to VEGF. Critical Issues: The mechanisms by which VEGF promotes angiogenesis are well established. Recent studies, however, indicate that VEGF can directly affect the activity of several nonendothelial cell types present in the skin. The implications of these extra-angiogenic effects of VEGF on wound repair are not yet known, but they suggest that this growth factor may play a more complex role during wound healing than previously believed. Future Directions: Despite the large number of studies focusing on VEGF and wound healing, it is clear that the current knowledge of how VEGF contributes to the repair of skin wounds is incomplete. Further research is needed to obtain a more comprehensive understanding of VEGF activities during the wound healing process.
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Cites
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Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
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Differential Roles of Macrophages in Diverse Phases of Skin Repair
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Control of hair growth and follicle size by VEGF-mediated angiogenesis
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Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice
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Cited by
Guan, Y., Niu, H., Liu, Z., Dang, Y., Shen, J., Zayed, M., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 631
Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Nourian Dehkordi, A., Mirahmadi Babaheydari, F., Chehelgerdi, M., & Raeisi Dehkordi, S. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 533
Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing
Mehrabi, T., Mesgar, A. S., & Mohammadi, Z. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00528 · Cited by 253
PLGA based drug delivery systems: promising carriers for wound healing activity
Chereddy, K. K., Vandermeulen, G., & Préat, V. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12404 · Cited by 215
High-throughput 5’ UTR engineering for enhanced protein production in non-viral gene therapies
Cao, J., Novoa, E. M., Zhang, Z., Chen, W. C. W., Liu, D., Choi, G. C. G., Wong, A. S. L., Wehrspaun, C., Kellis, M., & Lu, T. K. (2021) · Nature Communications · doi:10.1038/s41467-021-24436-7 · Cited by 159
Metadata
- Authors
- Johnson, K. E., & Wilgus, T. A.
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2014-10
- Volume
- 3
- Issue
- 10
- Pages
- 647-661
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- OpenAlex
- W2024623214
- Cited by
- 1,100
- References
- 14
- FWCI
- 30.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Johnson, K. E., & Wilgus, T. A. (2014). Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair. Advances in Wound Care. https://doi.org/10.1089/wound.2013.0517
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