The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The Effect of pH on the Extracellular Matrix and Biofilms
Open accessAbstract
Significance: Chronic wounds become caught in a state of inflammation causing an increase in levels of degrading proteases, which destroy components of the extracellular matrix (ECM) that are essential for the wound healing process. This review aims to highlight and provide readers with an overview of what is currently known about the role of pH and its effect on the ECM and biofilms within healing and nonhealing wounds. Recent Advances: The pH profiles of healthy skin, acute wounds, and chronic wounds differ significantly. Chronic wounds have an alkaline pH whereas healthy skin has a slightly acidic pH. Although there is evidence on the effect of pH on protease production and bacterial proliferation in wounds, there is little evidence to show its effect on ECM synthesis and degradation. Critical Issues: The implications for the complex nature of chronic wounds are that no single treatment is relevant for all wounds, but rather a combination of methodologies must be adopted. It is known that pH of a wound reduces throughout the stages of healing, suggesting that wound pH measurements could be beneficial to identify nonhealing wounds earlier and decide on the most appropriate course of treatment. Future Direction: Wound healing is a very complex process with multiple factors known to play a role. All aspects of the nonhealing wound (defective ECM, pH, microbial invasion, and excess proteases) need to be taken into account when investigating or clinically treating a chronic wound.
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Cites
Human skin wounds: A major and snowballing threat to public health and the economy
Sen, C. K., Gordillo, G. M., Roy, S., Kirsner, R., Lambert, L., Hunt, T. K., Gottrup, F., Gurtner, G. C., & Longaker, M. T. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00543.x · Cited by 2,965
James, G. A., Swogger, E., Wolcott, R., Pulcini, E. D., Secor, P., Sestrich, J., Costerton, J. W., & Stewart, P. S. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00321.x · Cited by 1,543
Interactions between extracellular matrix and growth factors in wound healing
Schultz, G. S., & Wysocki, A. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00466.x · Cited by 1,126
Edwards, R., & Harding, K. G. (2004) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200404000-00004 · Cited by 1,099
Influence of pH on wound-healing: a new perspective for wound-therapy?
Schneider, L. A., Korber, A., Grabbe, S., & Dissemond, J. (2007) · Archives of Dermatological Research · doi:10.1007/s00403-006-0713-x · Cited by 1,066
Wound healing and the role of fibroblasts
P., B. (2013) · Journal of Wound Care · doi:10.12968/jowc.2013.22.8.407 · Cited by 779
Biofilm bacteria: formation and comparative susceptibility to antibiotics.
Olson, M. E., Ceri, H., Morck, D. W., Buret, A. G., & Read, R. R. (2002) · Europe PMC (PubMed Central) · Cited by 687
Multiple bacterial species reside in chronic wounds: a longitudinal study
Gjødsbøl, K., Christensen, J. J., Karlsmark, T., Jørgensen, B., Klein, B. M., & Krogfelt, K. A. (2006) · International Wound Journal · doi:10.1111/j.1742-481x.2006.00159.x · Cited by 622
A review of the scientific evidence for biofilms in wounds
Percival, S. L., Hill, K. E., Williams, D. W., Hooper, S. J., Thomas, D. W., & Costerton, J. W. (2012) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2012.00836.x · Cited by 483
Self-citationDistribution of Fibronectin During Wound Healing in Vivo
Grinnell, F., Billingham, R. E., & Burgess, L. (1981) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12525694 · Cited by 472
Cited by
Ninan, N., Forget, A., Shastri, V. P., Voelcker, N. H., & Blencowe, A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10491 · Cited by 676
Optical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications
Steinegger, A., Wolfbeis, O. S., & Borisov, S. M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00451 · Cited by 622
Advanced Hydrogels as Wound Dressings
Tavakoli, S., & Klar, A. S. (2020) · Biomolecules · doi:10.3390/biom10081169 · Cited by 544
Design Challenges in Polymeric Scaffolds for Tissue Engineering
Echeverria Molina, M. I., Malollari, K. G., & Komvopoulos, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.617141 · Cited by 397
Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine
Huang, F., Lu, X., Yang, Y., Yang, Y., Li, Y., Kuai, L., Li, B., Dong, H., & Shi, J. (2023) · Advanced Science · doi:10.1002/advs.202203308 · Cited by 365
Metadata
- Authors
- Jones, E. M., Cochrane, C. A., & Percival, S. L.
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2015-07
- Volume
- 4
- Issue
- 7
- Pages
- 431-439
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- OpenAlex
- W2330090019
- Cited by
- 455
- References
- 42
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- green
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