Hypoxia-inducible Factor-1α mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,953

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

Semenza, G., Roth, P. H., Fang, H. M., & Wang, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31580-6 · Cited by 1,892

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

Jang, S. K., Kräusslich, H., Nicklin, M. J. H., Duke, G. M., Palmenberg, A. C., & Wimmer, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2636-2643.1988 · Cited by 1,390

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

Pause, A., Belsham, G. J., Gingras, A., Donzé, O., Lin, T.-A., Lawrence, J. C., & Sonenberg, N. (1994) · Nature · doi:10.1038/371762a0 · Cited by 1,242

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

Huang, E. L., Arany, Z. P., Livingston, D. M., & Bunn, H. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.32253 · Cited by 1,204

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

Ebert, B. L., Firth, J. D., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29083 · Cited by 569

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

Macejak, D. G., & Sarnow, P. (1991) · Nature · doi:10.1038/353090a0 · Cited by 563

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

Firth, J. D., Ebert, B. L., Pugh, C. W., & Ratcliffe, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6496 · Cited by 525

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

Stein, I., Itin, A., Einat, P., Skaliter, R., Grossman, Z., & Keshet, E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3112 · Cited by 507

Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

Ponte, P. A., Gunning, P. W., Blau, H. M., & Kedes, L. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.10.1783 · Cited by 383

AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A)

Lagnado, C. A., Brown, C. Y., & Goodall, G. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7984-7995.1994 · Cited by 335

Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes

Vagner, S., Gensac, M.-C., Maret, A., Bayard, F., Amalric, F., Prats, H., & Prats, A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.35 · Cited by 334

C-Myc 5′ untranslated region contains an internal ribosome entry segment

Stoneley, M., Paulin, F., Quesne, J. P. C. L., Chappell, S. A., & Willis, A. E. (1998) · Oncogene · doi:10.1038/sj.onc.1201763 · Cited by 333

Hypoxia Is a Strong Inducer of Vascular Endothelial Growth Factor mRNA Expression in the Heart

Ladoux, A., & Frelin, C. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2144 · Cited by 308

Two Independent Internal Ribosome Entry Sites Are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA

Huez, I., Créancier, L., Audigier, S., Gensac, M.-C., Prats, A., & Prats, H. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6178 · Cited by 308

A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection

Holčı́k, M., Lefebvre, C. A., Yeh, C., Chow, T. Y.-K., & Korneluk, R. G. (1999) · Nature Cell Biology · doi:10.1038/11109 · Cited by 302

Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription

Akiri, G., Nahari, D., Finkelstein, Y., Le, S., Elroy‐Stein, O., & Levi, B.-Z. (1998) · Oncogene · doi:10.1038/sj.onc.1202019 · Cited by 261

Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice

Kappel, A., Rönicke, V., Damert, A., Flamme, I., Risau, W., & Breier, G. (1999) · Blood · doi:10.1182/blood.v93.12.4284 · Cited by 223

c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis

Stoneley, M., Chappell, S. A., Jopling, C. L., Dickens, M., MacFarlane, M., & Willis, A. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1162-1169.2000 · Cited by 219

Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia

Schmaltz, C., Hardenbergh, P. H., Wells, A. G., & Fisher, D. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2845 · Cited by 216

Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene

Norris, M. L., & Millhorn, D. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23774 · Cited by 201

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.Preprint

Savant‐Bhonsale, S., & Cleveland, D. W. (1992) · Genes & Development · doi:10.1101/gad.6.10.1927 · Cited by 173

Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells.

Vagner, S., Touriol, C., Galy, B., Audigier, S., Gensac, M.-C., Amalric, F., Bayard, F., Prats, H., & Prats, A. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.5.1391 · Cited by 160

Regulation of Protein Synthesis

Vogel, H. J., & Vogel, R. H. (1967) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.36.070167.002511 · Cited by 133

Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia‐induced lethal damage

Åmellem, Ø., & Pettersen, E. O. (1991) · Cell Proliferation · doi:10.1111/j.1365-2184.1991.tb01144.x · Cited by 110

Internal Initiation of Translation Directed by the 5′-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation

Gan, W., & Rhoads, R. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.623 · Cited by 104

Human Actin Genes Are Single Copy for α-Skeletal and α-Cardiac Actin but Multicopy for β- and γ-Cytoskeletal Genes: 3′ Untranslated Regions Are Isotype Specific but Are Conserved in Evolution

Ponte, P. A., Gunning, P. W., Blau, H. M., & Kedes, L. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.10.1783-1791.1983 · Cited by 94

The vascular endothelial growth factor mRNA contains an internal ribosome entry site

Miller, D. L., Dibbens, J. A., Damert, A., Risau, W., Vadas, M. A., & Goodall, G. J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01025-4 · Cited by 82

Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions

Görlach, A., Camenisch, G., Kvietikova, I., Vogt, L., Wenger, R. H., & Gassmann, M. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00172-x · Cited by 76

Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2

Hogg, A., Schirm, S., Nakagoshi, H., Bartley, P., Ishii, S., Bishop, J. M., & Gonda, T. J. (1997) · Oncogene · doi:10.1038/sj.onc.1201472 · Cited by 66

Translation of NRF mRNA Is Mediated by Highly Efficient Internal Ribosome Entry

Oumard, A., Hennecke, M., Häuser, H., & Nourbakhsh, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2755-2759.2000 · Cited by 64

Regulation of protein synthesis in human cells exposed to extreme hypoxia.

Kraggerud, S. M., Sandvik, J. A., & Pettersen, E. O. (1995) · PubMed · Cited by 63

Hypoxia increases the association of 4E‐binding protein 1 with the initiation factor 4E in isolated rat hepatocytes

Tinton, S. A., & Calderón, P. B. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00185-4 · Cited by 59

Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348

Translational control in stress and apoptosis

Holčı́k, M., & Sonenberg, N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1618 · Cited by 1,409

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272

Hypoxia signalling through mTOR and the unfolded protein response in cancer

Wouters, B. G., & Koritzinsky, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2501 · Cited by 894

Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions

Görlach, A., Camenisch, G., Kvietikova, I., Vogt, L., Wenger, R. H., & Gassmann, M. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00172-x · Cited by 76

Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism

Young, R. M., Wang, S.-J., Gordan, J. D., Ji, X., Liebhaber, S. A., & Simon, M. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710079200 · Cited by 122

The polypyrimidine tract-binding protein stimulates HIF-1 IRES-mediated translation during hypoxia

Schepens, B. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1000 · Cited by 87

Disruption of HIF1Α translational control attenuates the HIF-dependent hypoxic response and solid tumour formation in vivoPreprint

Hunter, J. E., McHugh, O., Ecclestone, G. B., Child, F., Mearns, H., Robson, G., Dadzie, M., Rocha, S., Perkins, N. D., & Kenneth, N. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.02.514731

Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA- binding protein and a p53 family target, via mRNA translation

Cho, S.-J., Teng, I.-F., Zhang, M., Yin, T., Jung, Y.-S., & Chen, X. (2016)