The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes
Open accessAbstract
Endobrevin/VAMP-8 is an R-SNARE localized to endosomes, but it is unknown in which intracellular fusion step it operates. Using subcellular fractionation and quantitative immunogold electron microscopy, we found that endobrevin/VAMP-8 is present on all membranes known to communicate with early endosomes, including the plasma membrane, clathrin-coated pits, late endosomes, and membranes of thetrans-Golgi network. Affinity-purified antibodies that block the ability of endobrevin/VAMP-8 to form SNARE core complexes potently inhibit homotypic fusion of both early and late endosomes in vitro. Fab fragments were as active as intact immunoglobulin Gs. Recombinant endobrevin/VAMP-8 inhibited both fusion reactions with similar potency. We conclude that endobrevin/VAMP-8 operates as an R-SNARE in the homotypic fusion of early and late endosomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This complex brings endosomes/phagosomes in close proximity as a prerequisite for fusion, probably involving VAMP7 and 8.
“This complex brings endosomes/phagosomes in close proximity as a prerequisite for fusion (probably involving VAMP7 and 8) (35, 36).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Greene, L., & Tischler, A. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2424 · Cited by 5,594 · see citing works
Wessel, D., & Flügge, U. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90782-6 · Cited by 3,997 · see citing works
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239 · see citing works
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · cited 1× · see citing works
“In the neuronal SNARE complex, three Q-SNARE motifs (one contributed by syntaxin and two by SNAP-25) and one R-SNARE motif (contributed by synaptobrevin/VAMP) form an extended helical bundle (Sutton et al., 1998).”
Self-citationMechanisms of intracellular protein transport
Rothman, J. E. (1994) · Nature · doi:10.1038/372055a0 · Cited by 2,283 · see citing works
Wiedenmann, B. J., & Franke, W. W. (1985) · Cell · doi:10.1016/s0092-8674(85)80082-9 · Cited by 1,432 · see citing works
A new method of preparing gold probes for multiple-labeling cytochemistry.
Slot, J. W., & Geuze, H. J. (1985) · PubMed · Cited by 1,419 · see citing works
Membrane fusion and exocytosis.
Jahn, R., & Südhof, T. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,253 · see citing works
Self-citationEEA1 links PI(3)K function to Rab5 regulation of endosome fusion
Simonsen, A., Lippe, R., Christoforidis, S., Gaullier, J.-M., Brech, A., Callaghan, J., Toh, B.-H., Murphy, C., Zerial, M., & Stenmark, H. (1998) · Nature · doi:10.1038/28879 · Cited by 1,133 · see citing works
rab5 controls early endosome fusion in vitro
Gorvel, J., Chavrier, P., Zerial, M., & Gruenberg, J. E. (1991) · Cell · doi:10.1016/0092-8674(91)90316-q · Cited by 1,094 · see citing works
A TECHNIQUE FOR ULTRACRYOTOMY OF CELL SUSPENSIONS AND TISSUES
Tokuyasu, K. T. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.551 · Cited by 1,080 · see citing works
Fasshauer, D., Sutton, R. B., Brünger, A. T., & Jahn, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15781 · Cited by 1,055 · see citing works
Self-citationA 38,000-dalton membrane protein (p38) present in synaptic vesicles.
Jahn, R., SCHIEBLER, W., Ouimet, C. C., & Greengard, P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4137 · Cited by 851 · see citing works
Self-citationSynaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.
Hayashi, T., McMahon, H. T., Yamasaki, S., Binz, T., Hata, Y., Südhof, T. C., & Niemann, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06834.x · Cited by 798 · see citing works
The diversity of Rab proteins in vesicle transport
Novick, P., & Zerial, M. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80025-7 · Cited by 767 · see citing works
Navone, F., Jahn, R., Gioia, G. D., Stukenbrok, H., Greengard, P., & Camilli, P. V. D. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2511 · Cited by 674 · see citing works
Self-citationGörlich, D. (1993) · Cell · doi:10.1016/0092-8674(93)90483-7 · Cited by 674 · see citing works
Rab 7: an important regulator of late endocytic membrane traffic.
Feng, Y., Press, B., & Wandinger‐Ness, A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.6.1435 · Cited by 637 · see citing works
Horiuchi, H., Lippé, R., McBride, H. M., Rubino, M., Woodman, P. G., Stenmark, H., Rybin, V., Wilm, M. S., Ashman, K., Mann, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80380-3 · Cited by 595 · see citing works
Gruenberg, J. E., Griffiths, G. W., & Howell, K. E. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1301 · Cited by 586 · see citing works
McBride, H. M., Rybin, V., Murphy, C., Giner, A., Teasdale, R., & Zerial, M. (1999) · Cell · doi:10.1016/s0092-8674(00)81966-2 · Cited by 520 · see citing works
McMahon, H. T., Ushkaryov, Y. A., Edelmann, L., Link, E., Binz, T., Niemann, H., Jahn, R., & Südhof, T. C. (1993) · Nature · doi:10.1038/364346a0 · Cited by 509 · see citing works
Self-citationImproving structural integrity of cryosections for immunogold labeling
Liou, W., Geuze, H. J., & Slot, J. W. (1996) · Histochemistry and Cell Biology · doi:10.1007/bf02473201 · Cited by 507 · see citing works
Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
Stenmark, H., Vitale, G., Ullrich, O., & Zerial, M. (1995) · Cell · doi:10.1016/0092-8674(95)90120-5 · Cited by 474 · see citing works
Homotypic vacuolar fusion mediated by t- and v-SNAREs
Nichols, B. J., Ungermann, C., Pelham, H. R. B., Wickner, W. T., & Haas, A. (1997) · Nature · doi:10.1038/387199a0 · Cited by 455 · see citing works
Görlich, D., Prehn, S., Hartmann, E., Kalies, K., & Rapoport, T. A. (1992) · Cell · doi:10.1016/0092-8674(92)90517-g · Cited by 454 · see citing works
Aniento, F. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.6.1373 · Cited by 404 · see citing works
Neurotransmitter release — four years of SNARE complexes
Hanson, P. I., Heuser, J. E., & Jahn, R. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80057-8 · Cited by 394 · see citing works
Self-citationSynaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
Jessell, T. M., & Kandel, E. R. (1993) · Cell · doi:10.1016/s0092-8674(05)80025-x · Cited by 370 · see citing works
Ravichandran, V., Chawla, A., & Roche, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13300 · Cited by 354 · see citing works
A marker of early amacrine cell development in rat retina
Barnstable, C. J., Hofstein, R., & Akagawa, K. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90116-6 · Cited by 324 · see citing works
Mixed and Non-cognate SNARE Complexes
Fasshauer, D., Antonin, W., Margittai, M., Pabst, S., & Jahn, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15440 · Cited by 316 · see citing works
Self-citationSNARE Interactions Are Not Selective
Yang, B., Gonzalez, L. C., Prekeris, R., Steegmaier, M., Advani, R. J., & Scheller, R. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5649 · Cited by 315 · see citing works
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate
Burger, P. M., Mehl, E., Cameron, P. L., Maycox, P. R., Baumert, M., Lottspeich, F., Camilli, P. V. D., & Jahn, R. (1989) · Neuron · doi:10.1016/0896-6273(89)90240-7 · Cited by 299 · see citing works
Self-citationFasshauer, D., Eliason, W. K., Brünger, A. T., & Jahn, R. (1998) · Biochemistry · doi:10.1021/bi980542h · Cited by 270 · see citing works
Self-citationSeven Novel Mammalian SNARE Proteins Localize to Distinct Membrane Compartments
Advani, R. J., Bae, H.-R., Bock, J. B., Chao, D. S., Doung, Y.-C., Prekeris, R., Yoo, J.-S., & Scheller, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10317 · Cited by 263 · see citing works
Rabouille, C., Kondo, H., Newman, R., Hui, N., Freemont, P. S., & Warren, G. (1998) · Cell · doi:10.1016/s0092-8674(00)81128-9 · Cited by 256 · see citing works
Mannose 6-phosphate receptors in sorting and transport of lysosomal enzymes
Hille-Rehfeld, A. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00004-b · Cited by 249 · see citing works
Galli, T., Chilcote, T. J., Mundigl, O., Binz, T., Niemann, H., & Camilli, P. V. D. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.5.1015 · Cited by 226 · see citing works
Barriocanal, J. G., Bonifacino, J. S., Yuan, L. C., & Sandoval, I. V. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66630-x · Cited by 217 · see citing works
Three Novel Proteins of the Syntaxin/SNAP-25 Family
Steegmaier, M., Yang, B., Yoo, J.-S., Huang, B. C. B., Shen, M., Yu, S., Luo, Y., & Scheller, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34171 · Cited by 206 · see citing works
Vamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes
Advani, R. J., Yang, B., Prekeris, R., Lee, K. C., Klumperman, J., & Scheller, R. H. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.4.765 · Cited by 206 · see citing works
Export of Cellubrevin from the Endoplasmic Reticulum Is Controlled by BAP31
Annaert, W. G., Becker, B., Kistner, U., Reth, M. G., & Jahn, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.6.1397 · Cited by 168 · see citing works
Self-citationA model for structural similarity between different SNARE complexes based on sequence relationships
Weimbs, T., Mostov, K. E., Low, S. H., & Hofmann, K. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01285-9 · Cited by 153 · see citing works
Syntaxin 5 regulates endoplasmic reticulum to Golgi transport.
Dascher, C., Matteson, J., & Balch, W. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43884-7 · Cited by 151 · see citing works
Vesicle-associated Membrane Protein 4 is Implicated inTrans-Golgi Network Vesicle Trafficking
Steegmaier, M., Klumperman, J., Foletti, D. L., Yoo, J.-S., & Scheller, R. H. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.6.1957 · Cited by 150 · see citing works
Reconstitution of Retrograde Transport from the Golgi to the ER In Vitro
Spang, A., & Schekman, R. W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.3.589 · Cited by 140 · see citing works
von Mollard, G. F., Stahl, B., Walch-Solimena, C., Takei, K., Daniels, L. S., Khoklatchev, A., Camilli, P. V. D., Südhof, T. C., & Jahn, R. (1994) · PubMed · Cited by 127 · see citing works
Self-citationUngermann, C., & Wickner, W. T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3269 · Cited by 118 · see citing works
Wong, S. H., Zhang, T., Xu, Y., Subramaniam, V. N., Griffiths, G. W., & Hong, W. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.6.1549 · Cited by 115 · see citing works
Bock, J. B., & Scheller, R. H. (1997) · Nature · doi:10.1038/387133a0 · Cited by 98 · see citing works
Götte, M. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01272-0 · Cited by 92 · see citing works
Syntaxin 12, a Member of the Syntaxin Family Localized to the Endosome
Tang, B. L., Tan, A. E. H., Lim, L. K., Lee, S. S., Low, D. Y. H., & Hong, W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6944 · Cited by 91 · see citing works
SCAMP 37, a new marker within the general cell surface recycling system.
Brand, S., & Castle, J. D. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06053.x · Cited by 86 · see citing works
Fusion of Endosomes Involved in Synaptic Vesicle Recycling
Holroyd, C., Kistner, U., Annaert, W. G., & Jahn, R. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.9.3035 · Cited by 86 · see citing works
Self-citationSyntaxin 7, a Novel Syntaxin Member Associated with the Early Endosomal Compartment
Wong, S. H., Xu, Y., Zhang, T., & Hong, W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.375 · Cited by 85 · see citing works
Mammalian Sly1 Regulates Syntaxin 5 Function in Endoplasmic Reticulum to Golgi Transport
Dascher, C., & Balch, W. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.15866 · Cited by 84 · see citing works
GS32, a Novel Golgi SNARE of 32 kDa, Interacts Preferentially with Syntaxin 6
Wong, S. H., Xu, Y., Zhang, T., Griffiths, G. W., Lowe, S. L., Subramaniam, V. N., Seow, K. T., & Hong, W. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.1.119 · Cited by 73 · see citing works
Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes.
Link, E., McMahon, H. T., von Mollard, G. F., Yamasaki, S., Niemann, H., Südhof, T. C., & Jahn, R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46640-3 · Cited by 66 · see citing works
Self-citationNSF is required for transport from early to late endosomes
Robinson, L. J., Aniento, F., & Grüenberg, J. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.17.2079 · Cited by 44 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635 · see citing works
Self-citationMacrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works
Hong, W. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.03.014 · Cited by 629 · see citing works
Gromley, A., Yeaman, C. A., Rosa, J., Redick, S. D., Chen, C., Mirabelle, S., Guha, M., Sillibourne, J., & Doxsey, S. (2005) · Cell · doi:10.1016/j.cell.2005.07.027 · Cited by 433 · see citing works
Antonin, W., Holroyd, C., Fasshauer, D., Pabst, S., von Mollard, G. F., & Jahn, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6453 · Cited by 290 · see citing works
Self-citationTI‐VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages
Braun, V., Fraisier, V., Raposo, G., Hurbain, I., Sibarita, J., Chavrier, P., Galli, T., & Niedergang, F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600427 · Cited by 214 · see citing works
Syntaxin 2 and Endobrevin Are Required for the Terminal Step of Cytokinesis in Mammalian Cells
Low, S. H., Li, X., Miura, M., Kudo, N., Quiñones, B., & Weimbs, T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00122-9 · Cited by 184 · see citing works
Stein, A., Radhakrishnan, A., Riedel, D., Fasshauer, D., & Jahn, R. (2007) · Nature Structural &Molecular Biology · doi:10.1038/nsmb1305 · Cited by 175 · see citing works
Self-citationThe Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM
Miller, S. E., Sahlender, D. A., Graham, S. C., Höning, S., Robinson, M. S., Peden, A. A., & Owen, D. J. (2011) · Cell · doi:10.1016/j.cell.2011.10.038 · Cited by 192 · see citing works
Self-citationENDOCYTOTIC CYCLING OF PM PROTEINS
Murphy, A. S., Bandyopadhyay, A., Holstein, S. E. H., & Peer, W. A. (2005) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.56.032604.144150 · Cited by 174 · see citing works
A Role of VAMP8/Endobrevin in Regulated Exocytosis of Pancreatic Acinar Cells
Wang, C.-C., Ng, C. P., Lü, L., Atlashkin, V., Zhang, W., Seet, L., & Hong, W. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.002 · Cited by 172 · see citing works
Ganley, I. G., Espinosa, E. J., & Pfeffer, S. R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707136 · Cited by 171 · see citing works
VAMP-8 segregates mast cell–preformed mediator exocytosis from cytokine trafficking pathways
Tiwari, N., Wang, C.-C., Brochetta, C., Ke, G., Vita, F., Zeng, Q., Rivera, J., Soranzo, M. R., Zabucchi, G., Hong, W., et al. (2008) · Blood · doi:10.1182/blood-2007-07-103309 · Cited by 165 · see citing works
Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators
ROSSI, V., Banfield, D. K., Vacca, M., Dietrich, L. E. P., Ungermann, C., D’Esposito, M., Galli, T., & Filippini, F. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.10.002 · Cited by 165 · see citing works
SNARE Protein Mimicry by an Intracellular Bacterium
Delevoye, C., Nilges, M., Dehoux, P., Paumet, F., Perrinet, S., Dautry‐Varsat, A., & Subtil, A. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000022 · Cited by 163 · see citing works
Endobrevin/VAMP-8 Is the Primary v-SNARE for the Platelet Release Reaction
Ren, Q., Barber, H. K., Crawford, G. L., Karim, Z. A., Zhao, C., Choi, W., Wang, C.-C., Hong, W., & Whiteheart, S. W. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0785 · Cited by 163 · see citing works
Multiple roles of the vesicular‐SNARE TI‐VAMP in post‐Golgi and endosomal trafficking
Chaineau, M., Danglot, L., & Galli, T. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.026 · Cited by 149 · see citing works
Deletion of the SNARE vti1b in Mice Results in the Loss of a Single SNARE Partner, Syntaxin 8
Atlashkin, V., Kreykenbohm, V., Eskelinen, E., Wenzel, D., Fayyazi, A., & von Mollard, G. F. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5198-5207.2003 · Cited by 123 · see citing works
Béthune, J., Wieland, F., & Moelleken, J. (2006) · The Journal of Membrane Biology · doi:10.1007/s00232-006-0859-7 · Cited by 122 · see citing works
The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners
Kreykenbohm, V., Wenzel, D., Antonin, W., Atlachkine, V., & von Mollard, G. F. (2002) · European Journal of Cell Biology · doi:10.1078/0171-9335-00247 · Cited by 122 · see citing works
Self-citationEndosomal and Phagosomal SNAREs
Dingjan, I., Linders, P. T. A., Verboogen, D. R. J., Revelo, N. H., ter Beest, M., & van den Bogaart, G. (2018) · Physiological Reviews · doi:10.1152/physrev.00037.2017 · Cited by 113 · see citing works
Membrane Trafficking in Autophagy
Søreng, K., Neufeld, T. P., & Simonsen, A. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.001 · Cited by 110 · see citing works
Confocal imaging and tracking of the exocytotic routes for D ‐serine‐mediated gliotransmission
Martineau, M., Galli, T., Baux, G., & Mothet, J. (2008) · Glia · doi:10.1002/glia.20696 · Cited by 109 · see citing works
Control of Membrane Fusion During Spermiogenesis and the Acrosome Reaction1
Ramalho‐Santos, J., Schatten, G. P., & Moreno, R. D. (2002) · Biology of Reproduction · doi:10.1095/biolreprod67.4.1043 · Cited by 108 · see citing works
Sander, L. E., Frank, S. P. C., Bolat, S., Blank, U., Galli, T., Bigalke, H., Bischoff, S. C., & Lorentz, A. (2008) · European Journal of Immunology · doi:10.1002/eji.200737634 · Cited by 104 · see citing works
Cai, L., Loo, L. S., Atlashkin, V., Hanson, B. J., & Hong, W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01044-10 · Cited by 99 · see citing works
Logan, M. R., Lacy, P., Odemuyiwa, S. O., Steward, M., Davoine, F., Kita, H., & Moqbel, R. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01089.x · Cited by 98 · see citing works
VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis
Cosen-Binker, L. I., Binker, M. G., Wang, C.-C., Hong, W., & Gaisano, H. Y. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34672 · Cited by 95 · see citing works
Ernst, J., & Brunger, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211889200 · Cited by 97 · see citing works
Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex
Sun, W., Yan, Q., Vida, T. A., & Bean, A. J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302083 · Cited by 94 · see citing works
The Roles of Lysosomes in Inflammation and Autoimmune Diseases
Ge, W., Li, D., Gao, Y., & Cao, X. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.936587 · Cited by 93 · see citing works
Marshall, M. R., Pattu, V., Halimani, M., Maier‐Peuschel, M., Müller, M., Becherer, U., Hong, W., Hoth, M., Tschernig, T., Bryceson, Y. T., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201411093 · Cited by 92 · see citing works
Jean, S., Cox, S. E., Nassari, S., & Kiger, A. A. (2015) · EMBO Reports · doi:10.15252/embr.201439464 · Cited by 90 · see citing works
Wade, N., Bryant, N. J., Connolly, L. M., Simpson, R. J., Luzio, J. P., Piper, R. C., & James, D. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010838200 · Cited by 89 · see citing works
Vesicle trafficking and membrane remodelling in cytokinesis
Neto, H., Collins, L. L., & Gould, G. W. (2011) · Biochemical Journal · doi:10.1042/bj20110153 · Cited by 88 · see citing works
Evidence for Early Endosome‐like Fusion of Recently Endocytosed Synaptic Vesicles
Rizzoli, S. O., Bethani, I., Zwilling, D., Wenzel, D., Siddiqui, T. J., Brandhorst, D., & Jahn, R. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00466.x · Cited by 88 · see citing works
Self-citationDual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth
Zhu, D., Zhang, Y., Lam, P. P. L., Dolai, S., Liu, Y., Cai, E. P., Choi, D., Schroer, S. A., Kang, Y., Allister, E. M., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.001 · Cited by 87 · see citing works
Behrendorff, N., Dolai, S., Hong, W., Gaisano, H. Y., & Thorn, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.265199 · Cited by 84 · see citing works
Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling
Danglot, L., Chaineau, M., Dahan, M., Gendron, M., Boggetto, N., Perez, F., & Galli, T. (2010) · Journal of Cell Science · doi:10.1242/jcs.062497 · Cited by 84 · see citing works
Clues to CD2-associated Protein Involvement in Cytokinesis
Monzo, P., Gauthier, N. C., Keslair, F., Loubat, A., Field, C. M., MARCHAND‐BRUSTEL, Y. L., & Cormont, M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-09-0773 · Cited by 80 · see citing works
Li, X., Low, S. H., Miura, M., & Weimbs, T. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00185.2002 · Cited by 79 · see citing works
Proux‐Gillardeaux, V., Rudge, R. E., & Galli, T. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00288.x · Cited by 78 · see citing works
VAMP4 cycles from the cell surface to the trans-Golgi network via sorting and recycling endosomes
Tran, T. H. T., Zeng, Q., & Hong, W. (2007) · Journal of Cell Science · doi:10.1242/jcs.03387 · Cited by 78 · see citing works
Modulation of the Phagosome Proteome by Interferon-γ
Jutras, I., Houde, M., Currier, N. L., Boulais, J., Duclos, S., LaBoissière, S., Bonneil, É., Kearney, P., Thibault, P., Paramithiotis, E., et al. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700267-mcp200 · Cited by 77 · see citing works
The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation
Schäfer, I. B., Hesketh, G. G., Bright, N. A., Gray, S. R., Pryor, P. R., Evans, P. R., Luzio, J. P., & Owen, D. J. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2414 · Cited by 77 · see citing works
COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal
Xu, P., Hankins, H. M., MacDonald, C., Erlinger, S. J., Frazier, M. N., Diab, N. S., Piper, R. C., Jackson, L. P., MacGurn, J. A., & Graham, T. R. (2017) · eLife · doi:10.7554/elife.28342 · Cited by 74 · see citing works
Distinct v-SNAREs regulate direct and indirect apical delivery in polarized epithelial cells
Pocard, T., Bivic, A. L., Galli, T., & Zurzolo, C. (2007) · Journal of Cell Science · doi:10.1242/jcs.007948 · Cited by 69 · see citing works
Role of cholesterol in SNARE-mediated trafficking on intracellular membranes
Enrich, C., Rentero, C., Hierro, A., & Grewal, T. (2015) · Journal of Cell Science · doi:10.1242/jcs.164459 · Cited by 71 · see citing works
VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells
Chen, Y., Meng, D., Wang, H., Sun, R., Wang, D., Wang, S., Fan, J., Zhao, Y., Wang, J., Yang, S. T., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou219 · Cited by 69 · see citing works
Interleukin-6 secretion is limited by self-signaling in endosomes
Verboogen, D. R. J., Revelo, N. H., ter Beest, M., & van den Bogaart, G. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy038 · Cited by 62 · see citing works
Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins
Dietrich, L. E. P., Boeddinghaus, C., LaGrassa, T. J., & Ungermann, C. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(03)00094-6 · Cited by 61 · see citing works
Structural Basis of the Intracellular Sorting of the SNARE VAMP7 by the AP3 Adaptor Complex
Kent, H. M., Evans, P. R., Schäfer, I. B., Gray, S. R., Sanderson, C. M., Luzio, J. P., Peden, A. A., & Owen, D. J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.01.018 · Cited by 60 · see citing works
The Cytoplasmic Domain of Vamp4 and Vamp5 Is Responsible for Their Correct Subcellular Targeting
Zeng, Q., Tran, T. T. H., Tan, H.-X., & Hong, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303214200 · Cited by 56 · see citing works
VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release
Dingjan, I., Paardekooper, L. M., Verboogen, D. R. J., von Mollard, G. F., ter Beest, M., & van den Bogaart, G. (2017) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2017.06.007 · Cited by 55 · see citing works
Here come the newcomer granules, better late than never
Gaisano, H. Y. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.03.005 · Cited by 53 · see citing works
Cell-free fusion of bacteria-containing phagosomes with endocytic compartments
Becken, U., Jeschke, A., Veltman, K., & Haas, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007295107 · Cited by 52 · see citing works
Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation
Yamazaki, Y., Schönherr, C., Varshney, G. K., Dogru, M., Hallberg, B., & Palmer, R. H. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.1 · Cited by 54 · see citing works
Weng, N., Thomas, D. D. H., & Groblewski, G. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611108200 · Cited by 54 · see citing works
Endobrevin/VAMP8 mediates exocytotic release of hexosaminidase from rat basophilic leukaemia cells
Lippert, U., Ferrari, D. M., & Jahn, R. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.057 · Cited by 51 · see citing works
Self-citationBacteria‐generated PtdIns(3) P Recruits VAMP8 to Facilitate Phagocytosis
Dai, S., Zhang, Y., Weimbs, T., Yaffe, M. B., & Zhou, D. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00613.x · Cited by 50 · see citing works
Syntaxin7 Is Required for Lytic Granule Release from Cytotoxic T Lymphocytes
Pattu, V., Qu, B., Marshall, M. R., Becherer, U., Junker, C., Matti, U., Schwarz, E. C., Krause, E., Hoth, M., & Rettig, J. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01193.x · Cited by 50 · see citing works
Improved characterization of the insulin secretory granule proteomes
Schvartz, D., Brunner, Y., Couté, Y., Foti, M., Wollheim, C. B., & Sanchez, J. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.04.023 · Cited by 49 · see citing works
Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis
Wu, K., Jerdeva, G. V., da Costa, S. R., Sou, E., Schechter, J., & Hamm‐Alvarez, S. F. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.11.009 · Cited by 49 · see citing works
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis
Mukai, A., Mizuno, E., Kobayashi, K., Matsumoto, M., Nakayama, K. I., Kitamura, N., & Komada, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.027417 · Cited by 49 · see citing works
Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16
Wang, Y., Tai, G., Lü, L., Johannes, L., Hong, W., & Tang, B. L. (2005) · Molecular Membrane Biology · doi:10.1080/09687860500143829 · Cited by 48 · see citing works
Two Coiled-Coil Domains of Chlamydia trachomatis IncA Affect Membrane Fusion Events during Infection
Ronzone, E., & Paumet, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069769 · Cited by 47 · see citing works
Kuster, A., Nola, S., Dingli, F., Vacca, B., Gauchy, C., Beaujouan, J., Nunez, M., Moncion, T., Loew, D., Formstecher, É., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666362 · Cited by 45 · see citing works
Racchetti, G., Lorusso, A., Schulte, C., Gavello, D., Carabelli, V., D’Alessandro, R., & Meldolesi, J. (2009) · Journal of Cell Science · doi:10.1242/jcs.059634 · Cited by 42 · see citing works
Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins
Ahnert‐Hilger, G., Münster‐Wandowski, A., & Höltje, M. (2012) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-33570-9_8 · Cited by 41 · see citing works
Salmonella SipA mimics a cognate SNARE for host Syntaxin8 to promote fusion with early endosomes
Singh, P. K., Kapoor, A., Lomash, R. M., Kumar, K., Kamerkar, S. C., Pucadyil, T. J., & Mukhopadhyay, A. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201802155 · Cited by 38 · see citing works
Tan, Y. R., Chiow, K. H., Huang, D., & Wong, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00627.x · Cited by 39 · see citing works
Key proteins involved in insulin vesicle exocytosis and secretion
Xiong, Q., Yu, C., Zhang, Y., Ling, L., Wang, L., & Gao, J. (2017) · Biomedical Reports · doi:10.3892/br.2017.839 · Cited by 38 · see citing works
A Role for VAMP8/Endobrevin in Surface Deployment of the Water Channel Aquaporin 2
Wang, C.-C., Ng, C. P., Shi, H., Liew, H. C., Guo, K., Zeng, Q., & Hong, W. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00814-09 · Cited by 36 · see citing works
van Tol, S., Atkins, C., Bharaj, P., Johnson, K. N., Hage, A., Freiberg, A. N., & Rajsbaum, R. (2019) · Journal of Virology · doi:10.1128/jvi.01454-19 · Cited by 33 · see citing works
SNAREs and developmental disorders
Tang, B. L. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30067 · Cited by 33 · see citing works
Martín-Gómez, L., Villalba, A., Carballal, M. J., & Abollo, E. (2013) · Gene · doi:10.1016/j.gene.2013.09.085 · Cited by 34 · see citing works
Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice
Zong, H., Wang, C.-C., Vaitheesvaran, B., Kurland, I. J., Hong, W., & Pessin, J. E. (2010) · Diabetes · doi:10.2337/db10-0231 · Cited by 34 · see citing works
Specificity of botulinum protease for human VAMP family proteins
Yamamoto, H., Ida, T., Tsutsuki, H., Mori, M., Matsumoto, T., Kohda, T., Mukamoto, M., Goshima, N., Kozaki, S., & Ihara, H. (2012) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2012.00434.x · Cited by 34 · see citing works
Low, S. H., Marmorstein, L. Y., Miura, M., Li, X., Kudo, N., Marmorstein, A. D., & Weimbs, T. (2002) · Journal of Cell Science · doi:10.1242/jcs.00116 · Cited by 32 · see citing works
Verboogen, D. R. J., Mancha, N. G., ter Beest, M., & van den Bogaart, G. (2017) · eLife · doi:10.7554/elife.23525 · Cited by 32 · see citing works
Chapter 1 Macromolecular Trafficking and Immune Evasion in African Trypanosomes
Field, M. C., Lumb, J. H., Adung’a, V. O., Jones, N. G., & Engstler, M. (2009) · International review of cytology · doi:10.1016/s1937-6448(09)78001-3 · Cited by 31 · see citing works
SNARE Function Is Not Involved in Early Endosome Docking
Geumann, U., Barysch, S. V., Hoopmann, P., Jahn, R., & Rizzoli, S. O. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0457 · Cited by 31 · see citing works
Self-citationA Novel Function for SNAP29 (Synaptosomal-Associated Protein of 29 kDa) in Mast Cell Phagocytosis
Wesolowski, J., Caldwell, V., & Paumet, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049886 · Cited by 31 · see citing works
Woo, S. S., James, D. J., & Martin, T. F. J. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-08-0617 · Cited by 31 · see citing works
Wang, Y., Tzeng, H., Tsai, C.-H., Cheng, H., Lai, W., Liu, H., & Wang, Y. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.08.023 · Cited by 30 · see citing works
Chen, Y., Lang, M. L., & Wade, W. F. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00202.x · Cited by 30 · see citing works
Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells
Bilan, F., Nacfer, M., Fresquet, F., Norez, C., Melin‐Heschel, P., Martin-Berge, A., de Beauregard, M.-A. C., Becq, F., Kitzis, A., & Thoreau, V. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.04.012 · Cited by 30 · see citing works
Wankel, B., Ouyang, J., Guo, X., Hadjiolova, K., Miller, J. A., Liao, Y., Tham, D. K. L., Romih, R., de Andrade, L. R., Gumper, I., et al. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-04-0230 · Cited by 27 · see citing works
Afipia felis induces uptake by macrophages directly into a nonendocytic compartment
Lührmann, A., Streker, K., Schüttfort, A., Daniels, J. J. D., & Haas, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121190398 · Cited by 27 · see citing works
Messenger, S. W., Falkowski, M. A., Thomas, D. D. H., Jones, E. K., Hong, W., Giasano, H. Y., Boulis, N. M., & Groblewski, G. E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.593913 · Cited by 27 · see citing works
Merklinger, E., Schloetel, J.-G., Weber, P., Batoulis, H., Holz, S., Karnowski, N., Finke, J., & Lang, T. (2017) · eLife · doi:10.7554/elife.20705 · Cited by 26 · see citing works
Alterations in platelet secretion differentially affect thrombosis and hemostasis
Joshi, S., Banerjee, M., Zhang, J., Kesaraju, A., Pokrovskaya, I. D., Storrie, B., & Whiteheart, S. W. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018019166 · Cited by 26 · see citing works
Mashima, H., Suzuki, J., Hirayama, T., Yoshikumi, Y., Ohno, H., Ohnishi, H., Yasuda, H., Fujita, T., & Omata, M. (2008) · Infection and Immunity · doi:10.1128/iai.01573-07 · Cited by 26 · see citing works
Ho, Y., Cai, D. T., Wang, C.-C., Huang, D., & Wong, S. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3148 · Cited by 24 · see citing works
Caceres, P. S., Méndez, M., Haque, M. Z., & Ortiz, P. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.735167 · Cited by 24 · see citing works
Congenital disorder of glycosylation caused by starting site-specific variant in syntaxin-5
Linders, P. T. A., Gerretsen, E. C. F., Ashikov, A., Vals, M., de Boer, R., Revelo, N. H., Arts, R., Baerenfaenger, M., Zijlstra, F., Huijben, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26534-y · Cited by 23 · see citing works
A proteomic approach to identify endosomal cargoes controlling cancer invasiveness
Vera, J. D., Palmer, S. E., Hernandez-Fernaud, J. R., Dornier, E., Mitchell, L. E., Macpherson, I. R., Edwards, J., Zanivan, S. R., & Norman, J. C. (2017) · Journal of Cell Science · doi:10.1242/jcs.190835 · Cited by 23 · see citing works
Kehl, A., Göser, V., Reuter, T., Liss, V., Franke, M., John, C., Richter, C. P., Deiwick, J., & Hensel, M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008220 · Cited by 22 · see citing works
Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion
Pilliod, J., Desjardins, A., Pernègre, C., Jamann, H., Larochelle, C., Fon, E. A., & Leclerc, N. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013553 · Cited by 23 · see citing works
SNARE Proteins Mediate α-Synuclein Secretion via Multiple Vesicular Pathways
Zhao, X., Guan, Y., Liu, F., Yan, S., Wang, Y., Hu, M., Li, Y., Li, R., & Zhang, C. X. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02599-0 · Cited by 21 · see citing works
- Authors
- Antonin, W., Holroyd, C., Tikkanen, R., Höning, S., & Jahn, R.
- Affiliations
- Max Planck Institute for Biophysical Chemistry (DE)
- University of Bonn (DE)
- University of Göttingen (DE)
- Venue
- Molecular Biology of the Cell
- Published
- 2000-10
- Volume
- 11
- Issue
- 10
- Pages
- 3289-3298
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC14992
- OpenAlex
- W2148157392
- Cited by
- 156
- References
- 60
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 14
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular Biology of the Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- R-SNARE, homotypic fusion, early endosomes, late endosomes, membrane trafficking, clathrin-coated pits, trans-Golgi network, endosomal membrane fusion
- MeSH terms
- Animals, Cell Fractionation, Cell Membrane, Cell-Free System, Coated Pits, Cell-Membrane, Membrane Fusion, Membrane Proteins, Endosomes, Synaptophysin, trans-Golgi Network, Vesicular Transport Proteins, SNARE Proteins, R-SNARE Proteins, Qa-SNARE Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
