The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Growth-Regulatory Protein HCRP1/hVps37A Is a Subunit of Mammalian ESCRT-I and Mediates Receptor Down-Regulation
Open accessAbstract
The biogenesis of multivesicular bodies and endosomal sorting of membrane cargo are driven forward by the endosomal sorting complexes required for transport, ESCRT-I, -II, and -III. ESCRT-I is characterized in yeast as a complex consisting of Vps23, Vps28, and Vps37. Whereas mammalian homologues of Vps23 and Vps28 (named Tsg101 and hVps28, respectively) have been identified and characterized, a mammalian counterpart of Vps37 has not yet been identified. Here, we show that a regulator of proliferation, hepatocellular carcinoma related protein 1 (HCRP1), interacts with Tsg101, hVps28, and their upstream regulator Hrs. The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-containing proteins. HCRP1 cofractionates with Tsg101 and hVps28 by size exclusion chromatography and colocalizes with hVps28 on LAMP1-positive endosomes. Whereas depletion of Tsg101 by siRNA reduces cellular levels of both hVps28 and HCRP1, depletion of HCRP1 has no effect on Tsg101 or hVps28. Nevertheless, HCRP1 depletion strongly retards epidermal growth factor (EGF) receptor degradation. Together, these results indicate that HCRP1 is a subunit of mammalian ESCRT-I and that its function is essential for lysosomal sorting of EGF receptors.
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Cites
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369
Martin-Serrano, J., Zang, T., & Bieniasz, P. D. (2001) · Nature Medicine · doi:10.1038/nm1201-1313 · Cited by 710
Bishop, N., & Woodman, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009863200 · Cited by 187
Cited by
Huang, F., Kirkpatrick, D., Jiang, X., Gygi, S., & Sorkin, A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.018 · Cited by 497
Babst, M. (2005) · Traffic · doi:10.1111/j.1600-0854.2004.00246.x · Cited by 376
Teo, H., Gill, D. J., Sun, J., Perisic, O., Veprintsev, D. B., Vallis, Y., Emr, S. D., & Williams, R. L. (2006) · Cell · doi:10.1016/j.cell.2006.01.047 · Cited by 242
Endosomal and non-endosomal functions of ESCRT proteins
Slagsvold, T., Pattni, K., Malerød, L., & Stenmark, H. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.004 · Cited by 238
Self-citationHuman ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release
Langelier, C., von Schwedler, U. K., Fisher, R. D., De Domenico, I., White, P. L., Hill, C. P., Kaplan, J., Ward, D., & Sundquist, W. I. (2006) · Journal of Virology · doi:10.1128/jvi.01049-06 · Cited by 166
Metadata
- Authors
- Bache, K. G., Slagsvold, T., Cabezas, A., Rosendal, K. R., Raiborg, C., & Stenmark, H.
- Venue
- Molecular Biology of the Cell
- Published
- 2004-09
- Volume
- 15
- Issue
- 9
- Pages
- 4337-4346
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2158785421
- Cited by
- 159
- References
- 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Bache, K. G., Slagsvold, T., Cabezas, A., Rosendal, K. R., Raiborg, C., & Stenmark, H. (2004). The Growth-Regulatory Protein HCRP1/hVps37A Is a Subunit of Mammalian ESCRT-I and Mediates Receptor Down-Regulation. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e04-03-0250
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