Anillin binds nonmuscle myosin II and regulates the contractile ring
Open accessAbstract
We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation. We show that despite their interaction, anillin and myosin II are independently targeted to the contractile ring. Depletion of anillin in Drosophila or human cultured cells results in cytokinesis failure. Human cells depleted for anillin fail to properly regulate contraction by myosin II late in cytokinesis and fail in abscission. We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis.
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Anillin is delivered to the CCF where it normally binds to both Myosin II and Septin.
“Anillin is delivered to the CCF where it normally binds to both Myosin II and Septin [20, 25]”
From Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit (2015) · cites this paper as [25]
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- Authors
- Straight, A. F., Field, C. M., & Mitchison, T. J.
- Affiliations
- Stanford Medicine (US)
- Harvard University (US)
- Venue
- Molecular Biology of the Cell
- Published
- 2005-01
- Volume
- 16
- Issue
- 1
- Pages
- 193-201
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC539163
- OpenAlex
- W2127504108
- Cited by
- 283
- References
- 41
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 13
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Institute of General Medical Sciences (GM-023928, R01GM023928)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- anillin, non-muscle myosin II, contractile ring, cytokinesis, myosin light chain phosphorylation, abscission, cytokinesis failure, protein-protein interaction, Drosophila
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Chromatography, Chromatography, Affinity, Cloning, Molecular, Contractile Proteins, Cytoskeleton, DNA, Drosophila, HeLa Cells, Humans, Interphase, Metaphase, Microscopy, Fluorescence, Molecular Sequence Data, Muscle Contraction, Myosins, Phosphorylation, Protein Binding, RNA, RNA, Double-Stranded, Xenopus laevis, Blotting, Western, Sequence Homology, Amino Acid, Myosin Type II, RNA Interference, Immunoprecipitation, Cytokinesis
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