The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Anillin Binds Nonmuscle Myosin II and Regulates the Contractile Ring
Open accessAbstract
We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation. We show that despite their interaction, anillin and myosin II are independently targeted to the contractile ring. Depletion of anillin in Drosophila or human cultured cells results in cytokinesis failure. Human cells depleted for anillin fail to properly regulate contraction by myosin II late in cytokinesis and fail in abscission. We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis.
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“Anillin is delivered to the CCF where it normally binds to both Myosin II and Septin [20, 25]”
From Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit (2015) · cites this paper as [25]
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Cites
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., & Kaibuchi, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20246 · Cited by 2,009
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
Straight, A. F., Cheung, A., Limouze, J., Chen, I., Westwood, N. J., Sellers, J. R., & Mitchison, T. J. (2003) · Science · doi:10.1126/science.1081412 · Cited by 1,412
Self-citation[18] Purification of muscle actin
Pardee, J. D., & Aspudich, J. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)85020-9 · Cited by 1,190
Murray, A. W. (2004) · Cell · doi:10.1016/s0092-8674(03)01080-8 · Cited by 1,079
Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination
Lozanne, A. D., & Spudich, J. A. (1987) · Science · doi:10.1126/science.3576222 · Cited by 988
Chapter 30 Cell Cycle Extracts
Murray, A. W. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)60298-8 · Cited by 942
Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum
Knecht, D. A., & Loomis, W. F. (1987) · Science · doi:10.1126/science.3576221 · Cited by 679
Self- and actin-templated assembly of Mammalian septins
Kinoshita, M., Field, C. M., Coughlin, M. L., Straight, A. F., & Mitchison, T. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00366-0 · Cited by 526
Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex.
Field, C. M., & Alberts, B. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.1.165 · Cited by 440
Murray, A. W. (1991) · PubMed · Cited by 438
The effect of myosin antibody on the division of starfish blastomeres
Mabuchi, I., & Okuno, M. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.74.1.251 · Cited by 437
Wu, J., Kuhn, J. R., Kovar, D. R., & Pollard, T. D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00324-1 · Cited by 391
RAPPAPORT, R. (1990) · Springer eBooks · doi:10.1007/978-3-642-83631-2_1 · Cited by 361
Polo-like kinases: positive regulators of cell division from start to finish
Nigg, E. A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80121-x · Cited by 344
Glotzer, M. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.351 · Cited by 342
Role of Polo Kinase and Mid1p in Determining the Site of Cell Division in Fission Yeast
Bähler, J., Steever, A. B., Wheatley, S. P., Wang, Y.-L., Pringle, J. R., Gould, K. L., & McCollum, D. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.6.1603 · Cited by 315
Oegema, K., Savoian, M. S., Mitchison, T. J., & Field, C. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.3.539 · Cited by 309
The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast.Preprint
Sohrmann, M., Fankhauser, C., Brodbeck, C., & Simanis, V. (1996) · Genes & Development · doi:10.1101/gad.10.21.2707 · Cited by 252
Félix, M., Cohen, P., & Karsenti, E. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08159.x · Cited by 248
Molecular Dissection of Cytokinesis by RNA Interference inDrosophilaCultured Cells
Somma, M. P., Fasulo, B., Cenci, G., Cundari, E., & Gatti, M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0589 · Cited by 240
Cytokinesis in eukaryotes: a mechanistic comparison
Field, C. M., Li, R., & Oegema, K. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80009-x · Cited by 239
[30] Smooth muscle myosin light chain kinase
Walsh, M. P., Hinkins, S., Dąbrowska, R., & Hartshorne, D. J. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)99063-8 · Cited by 226
RAPPAPORT, R. (1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511529764 · Cited by 206
Paoletti, A., & Chang, F. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.8.2757 · Cited by 205
Yamashiro, S., Totsukawa, G., Yamakita, Y., Sasaki, Y., Madaule, P., Ishizaki, T., Narumiya, S., & Matsumura, F. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-07-0427 · Cited by 202
Microtubules, membranes and cytokinesis
Straight, A. F., & Field, C. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00746-6 · Cited by 191
Self-citationKelley, C. A., Sellers, J. R., Gard, D. L., Bui, D., Adelstein, R. S., & Baines, I. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.3.675 · Cited by 163
Tasto, J. J., Morrell‐Falvey, J. L., & Gould, K. L. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211126 · Cited by 158
In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cells
Yamakita, Y., Yamashiro, S., & Matsumura, F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.1.129 · Cited by 155
Mid2p stabilizes septin rings during cytokinesis in fission yeast
Berlin, A., Paoletti, A., & Chang, F. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212016 · Cited by 155
Pinder, J. C., Fowler, R. E., Dluzewski, A. R., Bannister, L. H., Lavin, F. M., Mitchell, G. H., Wilson, R. J., & Gratzer, W. B. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.13.1831 · Cited by 143
Motegi, F., Mishra, M., Balasubramanian, M. K., & Mabuchi, I. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200402097 · Cited by 119
Sellers, J. R. (1999) · doi:10.1093/oso/9780198505099.001.0001 · Cited by 96
Baculovirus Expression of Chicken Nonmuscle Heavy Meromyosin II-B
Pato, M. D., Sellers, J. R., Preston, Y. A., Harvey, E. V., & Adelstein, R. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2689 · Cited by 68
src64andtec29are required for microfilament contraction duringDrosophilacellularization
Thomas, J. H., & Wieschaus, E. F. (2004) · Development · doi:10.1242/dev.00989 · Cited by 64
A Conserved Negatively Charged Amino Acid Modulates Function in Human Nonmuscle Myosin IIA
Wang, F., Harvey, E. V., Conti, M. A., Wei, D., & Sellers, J. R. (2000) · Biochemistry · doi:10.1021/bi000133x · Cited by 62
Purification and characterization of platelet myosin
Daniel, J. L., & Sellers, J. R. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)15054-g · Cited by 39
Wheatley, S. P., O’Connell, C. B., & Wang, Y. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.8.2173 · Cited by 32
Mansfield, G. S., Al-Shirawi, D. Y., Ketchum, A., Newbern, C. E., & Kiehart, D. P. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0009 · Cited by 32
[31] Purification of nonmuscle myosins
Pollard, T. D. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)85033-7 · Cited by 29
Differential expression of non-muscle myosin heavy chain genes during Xenopus embryogenesis
Bhatia‐Dey, N., Taira, M., Conti, M. A., Nooruddin, H., & Adelstein, R. S. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00136-1 · Cited by 16
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Charras, G., Hu, C., Coughlin, M. L., & Mitchison, T. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602085 · Cited by 640
Green, R. A., Paluch, E. K., & Oegema, K. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155718 · Cited by 586
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Saarikangas, J., Zhao, H., & Lappalainen, P. (2010) · Physiological Reviews · doi:10.1152/physrev.00036.2009 · Cited by 515
Animal Cytokinesis: From Parts List to Mechanisms
Eggert, U., Mitchison, T. J., & Field, C. M. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133425 · Cited by 449
Metadata
- Authors
- Straight, A. F., Field, C. M., & Mitchison, T. J.
- Affiliations
- Stanford Medicine (US)
- Harvard University (US)
- Venue
- Molecular Biology of the Cell
- Published
- 2005-01
- Volume
- 16
- Issue
- 1
- Pages
- 193-201
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC539163
- OpenAlex
- W2127504108
- Cited by
- 283
- References
- 41
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 13
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Institute of General Medical Sciences (GM-023928, R01GM023928)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- anillin, non-muscle myosin II, contractile ring, cytokinesis, myosin light chain phosphorylation, abscission, cytokinesis failure, protein-protein interaction, Drosophila
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Chromatography, Chromatography, Affinity, Cloning, Molecular, Contractile Proteins, Cytoskeleton, DNA, Drosophila, HeLa Cells, Humans, Interphase, Metaphase, Microscopy, Fluorescence, Molecular Sequence Data, Muscle Contraction, Myosins, Phosphorylation, Protein Binding, RNA, RNA, Double-Stranded, Xenopus laevis, Blotting, Western, Sequence Homology, Amino Acid, Myosin Type II, RNA Interference, Immunoprecipitation, Cytokinesis
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