The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Anillin Binds Nonmuscle Myosin II and Regulates the Contractile Ring
Open accessAbstract
We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation. We show that despite their interaction, anillin and myosin II are independently targeted to the contractile ring. Depletion of anillin in Drosophila or human cultured cells results in cytokinesis failure. Human cells depleted for anillin fail to properly regulate contraction by myosin II late in cytokinesis and fail in abscission. We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Anillin is delivered to the CCF where it normally binds to both Myosin II and Septin [20, 25]”
From Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit (2015) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., & Kaibuchi, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20246 · Cited by 2,009
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor
Straight, A. F., Cheung, A., Limouze, J., Chen, I., Westwood, N. J., Sellers, J. R., & Mitchison, T. J. (2003) · Science · doi:10.1126/science.1081412 · Cited by 1,412
Self-citation[18] Purification of muscle actin
Pardee, J. D., & Aspudich, J. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)85020-9 · Cited by 1,190
Murray, A. W. (2004) · Cell · doi:10.1016/s0092-8674(03)01080-8 · Cited by 1,079
Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination
Lozanne, A. D., & Spudich, J. A. (1987) · Science · doi:10.1126/science.3576222 · Cited by 988
Chapter 30 Cell Cycle Extracts
Murray, A. W. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)60298-8 · Cited by 942
Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum
Knecht, D. A., & Loomis, W. F. (1987) · Science · doi:10.1126/science.3576221 · Cited by 679
Self- and actin-templated assembly of Mammalian septins
Kinoshita, M., Field, C. M., Coughlin, M. L., Straight, A. F., & Mitchison, T. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00366-0 · Cited by 526
Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex.
Field, C. M., & Alberts, B. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.1.165 · Cited by 440
Murray, A. W. (1991) · PubMed · Cited by 438
Cited by
Sorted by citations
The Molecular Requirements for Cytokinesis
Glotzer, M. (2005) · Science · doi:10.1126/science.1096896 · Cited by 710
Reassembly of contractile actin cortex in cell blebs
Charras, G., Hu, C., Coughlin, M. L., & Mitchison, T. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602085 · Cited by 640
Green, R. A., Paluch, E. K., & Oegema, K. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155718 · Cited by 586
Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides
Saarikangas, J., Zhao, H., & Lappalainen, P. (2010) · Physiological Reviews · doi:10.1152/physrev.00036.2009 · Cited by 515
Animal Cytokinesis: From Parts List to Mechanisms
Eggert, U., Mitchison, T. J., & Field, C. M. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133425 · Cited by 449
Metadata
- Authors
- Straight, A. F., Field, C. M., & Mitchison, T. J.
- Affiliations
- Stanford Medicine (US)
- Harvard University (US)
- Venue
- Molecular Biology of the Cell
- Published
- 2005-01
- Volume
- 16
- Issue
- 1
- Pages
- 193-201
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC539163
- OpenAlex
- W2127504108
- Cited by
- 283
- References
- 41
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 15 · 2016: 16 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 13
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Institute of General Medical Sciences (GM-023928, R01GM023928)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- anillin, non-muscle myosin II, contractile ring, cytokinesis, myosin light chain phosphorylation, abscission, cytokinesis failure, protein-protein interaction, Drosophila
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Chromatography, Chromatography, Affinity, Cloning, Molecular, Contractile Proteins, Cytoskeleton, DNA, Drosophila, HeLa Cells, Humans, Interphase, Metaphase, Microscopy, Fluorescence, Molecular Sequence Data, Muscle Contraction, Myosins, Phosphorylation, Protein Binding, RNA, RNA, Double-Stranded, Xenopus laevis, Blotting, Western, Sequence Homology, Amino Acid, Myosin Type II, RNA Interference, Immunoprecipitation, Cytokinesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
