Mitchison, Timothy J.

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology

Cell death mechanisms and regulationFerroptosis and cancer prognosis

Cited by 3,068

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

Niethammer, P., Grabher, C., Look, A. T., & Mitchison, T. J. (2009) · Nature

Zebrafish Biomedical Research ApplicationsWound Healing and Treatments

Cited by 1,541

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

Straight, A. F., Cheung, A., Limouze, J., Chen, I., Westwood, N. J., Sellers, J. R., & Mitchison, T. J. (2003) · Science

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 1,412

Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5

Kapoor, T. M., Mayer, T. U., Coughlin, M. L., & Mitchison, T. J. (2000) · The Journal of Cell Biology

Microtubule and mitosis dynamicsHeterocyclic Compound Synthesis and Bioactivity

Cited by 717

Kin I kinesins are microtubule-destabilizing enzymes

Desai, A., Verma, S., Mitchison, T. J., & Walczak, C. E. (1999) · Cell

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 708

Multidimensional Drug Profiling By Automated Microscopy

Perlman, Z. E., Slack, M. D., Feng, Y., Mitchison, T. J., Wu, L. F., & Altschuler, S. J. (2004) · Science

Cell Image Analysis TechniquesSingle-cell and spatial transcriptomics

Cited by 660

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 564

A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity

Walczak, C. E., Vernos, I., Mitchison, T. J., Karsenti, E., & Heald, R. (1998) · Current Biology

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 396

The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns

Loose, M., & Mitchison, T. J. (2014) · Nature Cell Biology

Bacterial Genetics and BiotechnologyMicrotubule and mitosis dynamics

Cited by 378

Integrating high-content screening and ligand-target prediction to identify mechanism of action

Young, D. W., Bender, A., Hoyt, J., McWhinnie, E., Chirn, G.-W., Tao, C. Y., Tallarico, J. A., Labow, M., Jenkins, J. L., Mitchison, T. J., et al. (2008) · Nature Chemical Biology

Computational Drug Discovery MethodsCell Image Analysis Techniques

Cited by 345

Anillin binds nonmuscle myosin II and regulates the contractile ring

Straight, A. F., Field, C. M., & Mitchison, T. J. (2005) · Molecular Biology of the Cell

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 283

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

Silva, M. C., Ferguson, F. M., Cai, Q., Donovan, K. A., Nandi, G., Patnaik, D., Zhang, T., Huang, H.-T., Lucente, D. E., Dickerson, B. C., et al. (2019) · eLife

Alzheimer's disease research and treatmentsProtein Degradation and Inhibitors

Cited by 283

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

Sawin, K. E., & Mitchison, T. J. (1995) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 271

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

Haggarty, S. J., Mayer, T. U., Miyamoto, D. T., Fathi, R., King, R. W., Mitchison, T. J., & Schreiber, S. L. (2000) · Chemistry & Biology

Microtubule and mitosis dynamicsHeterocyclic Compound Synthesis and Bioactivity

Cited by 251

Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity

Maresca, T. J., Groen, A. C., Gatlin, J. C., Ohi, R., Mitchison, T. J., & Salmon, E. D. (2009) · Current Biology

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 89

Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic

Shi, J., & Mitchison, T. J. (2017) · Endocrine-Related Cancer

Microtubule and mitosis dynamicsCell death mechanisms and regulation

Cited by 79

Diverse microtubule-destabilizing drugs induce equivalent molecular pathway responses in endothelial cells

Horin, L. J., Sonnett, M., Li, B., & Mitchison, T. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory)

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 4