The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A Role for Fis1 in Both Mitochondrial and Peroxisomal Fission in Mammalian Cells
Open accessAbstract
The mammalian dynamin-like protein DLP1/Drp1 has been shown to mediate both mitochondrial and peroxisomal fission. In this study, we have examined whether hFis1, a mammalian homologue of yeast Fis1, which has been shown to participate in mitochondrial fission by an interaction with DLP1/Drp1, is also involved in peroxisomal growth and division. We show that hFis1 localizes to peroxisomes in addition to mitochondria. Through differential tagging and deletion experiments, we demonstrate that the transmembrane domain and the short C-terminal tail of hFis1 is both necessary and sufficient for its targeting to peroxisomes and mitochondria, whereas the N-terminal region is required for organelle fission. hFis1 promotes peroxisome division upon ectopic expression, whereas silencing of Fis1 by small interfering RNA inhibited fission and caused tubulation of peroxisomes. These findings provide the first evidence for a role of Fis1 in peroxisomal fission and suggest that the fission machinery of mitochondria and peroxisomes shares common components.
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“DLP-1 has a shared function in peroxisomal and mitochondrial fission, and is recruited to peroxisomes by two mitochondrial-associated fission factors, mitochondrial fission factor (MFF) (Gandre-Babbe and van der Bliek, 2008), and mitochondrial fission 1 (FIS1), following PEX11β-mediated elongation (Koch et al., 2005; Itoyama et al., 2013).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Koch et al., 2005
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Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938
The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,370
Lazarow, P. B., & Fujiki, Y. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.002421 · Cited by 1,114
van den BOSCH, H., Schutgens, R. B. H., Wanders, R. J. A., & Tager, J. M. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.001105 · Cited by 844
Yoon, Y., Krueger, E. W., Oswald, B. J., & McNiven, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5409-5420.2003 · Cited by 820
The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
Bleazard, W., McCaffery, J. M., King, E. J., Bale, S., Mozdy, A. D., Tieu, Q., Nunnari, J. M., & Shaw, J. M. (1999) · Nature Cell Biology · doi:10.1038/13014 · Cited by 795
Mozdy, A. D., McCaffery, J. M., & Shaw, J. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.367 · Cited by 731
C. elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer Membrane
Labrousse, A. M., Zappaterra, M. D., Rube, D. A., & van der Bliek, A. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80391-3 · Cited by 670
hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery
James, D. I., Parone, P. A., Mattenberger, Y., & Martinou, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303758200 · Cited by 653
Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape
Sesaki, H., & Jensen, R. E. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.4.699 · Cited by 531
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
Mitochondrial fusion and fission in cell life and death
Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002
Functions and dysfunctions of mitochondrial dynamics
Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
Losón, O. C., Song, Z., Chen, H., & Chan, D. C. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-10-0721 · Cited by 1,235
Fusion and fission: interlinked processes critical for mitochondrial health
Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196
Metadata
- Authors
- Koch, A., Yoon, Y., Bonekamp, N. A., McNiven, M. A., & Schrader, M.
- Affiliations
- Philipps University of Marburg (DE)
- University of Rochester Medicine (US)
- Mayo Clinic (US)
- Venue
- Molecular Biology of the Cell
- Published
- 2005-11
- Volume
- 16
- Issue
- 11
- Pages
- 5077-5086
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC1266408
- OpenAlex
- W2128023952
- Cited by
- 308
- References
- 42
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 13 · 2023: 13 · 2022: 16 · 2021: 8 · 2020: 17 · 2019: 10 · 2018: 17 · 2017: 11 · 2016: 15 · 2015: 17 · 2014: 14 · 2013: 24 · 2012: 15
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Philipps-Universität Marburg
- La Trobe University
- Universität Heidelberg
- Université de Genève
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- Fis1, mitochondrial fission, Drp1, dynamin-like protein, peroxisome division, peroxisome targeting, transmembrane domain, C-terminal tail, mammalian cells
- MeSH terms
- Animals, Chlorocebus aethiops, Humans, Membrane Proteins, Microtubule-Associated Proteins, Mitochondria, Transfection, COS Cells, GTP Phosphohydrolases, Peroxisomes, Mitochondrial Proteins, Dynamins, RNA, Small Interfering, Cell Line, Tumor, Rats
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