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Cited by 308Mitochondrial Function and PathologyAutophagy in Disease and TherapyCellular transport and secretion

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

A Role for Fis1 in Both Mitochondrial and Peroxisomal Fission in Mammalian Cells

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Koch, Annett, Yoon, Yisang, Bonekamp, Nina A., McNiven, Mark A., Schrader, Michael·2005·Molecular Biology of the Cell
DOI 10.1091/mbc.e05-02-0159PMC PMC1266408
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Abstract

The mammalian dynamin-like protein DLP1/Drp1 has been shown to mediate both mitochondrial and peroxisomal fission. In this study, we have examined whether hFis1, a mammalian homologue of yeast Fis1, which has been shown to participate in mitochondrial fission by an interaction with DLP1/Drp1, is also involved in peroxisomal growth and division. We show that hFis1 localizes to peroxisomes in addition to mitochondria. Through differential tagging and deletion experiments, we demonstrate that the transmembrane domain and the short C-terminal tail of hFis1 is both necessary and sufficient for its targeting to peroxisomes and mitochondria, whereas the N-terminal region is required for organelle fission. hFis1 promotes peroxisome division upon ectopic expression, whereas silencing of Fis1 by small interfering RNA inhibited fission and caused tubulation of peroxisomes. These findings provide the first evidence for a role of Fis1 in peroxisomal fission and suggest that the fission machinery of mitochondria and peroxisomes shares common components.

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Metadata

Authors
Koch, A., Yoon, Y., Bonekamp, N. A., McNiven, M. A., & Schrader, M.
Affiliations
  • Philipps University of Marburg (DE)
  • University of Rochester Medicine (US)
  • Mayo Clinic (US)
ORCID
Venue
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Published
2005-11
Volume
16
Issue
11
Pages
5077-5086
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
DOI
10.1091/mbc.e05-02-0159
PMC
PMC1266408
OpenAlex
W2128023952
Cited by
308
References
42
Citations by year
2026: 8 · 2025: 8 · 2024: 13 · 2023: 13 · 2022: 16 · 2021: 8 · 2020: 17 · 2019: 10 · 2018: 17 · 2017: 11 · 2016: 15 · 2015: 17 · 2014: 14 · 2013: 24 · 2012: 15
FWCI
6.42
Type
journal article
Language
en
Open access
Locations
  • Molecular Biology of the Cell (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Philipps-Universität Marburg
  • La Trobe University
  • Universität Heidelberg
  • Université de Genève
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
Fis1, mitochondrial fission, Drp1, dynamin-like protein, peroxisome division, peroxisome targeting, transmembrane domain, C-terminal tail, mammalian cells
MeSH terms
Animals, Chlorocebus aethiops, Humans, Membrane Proteins, Microtubule-Associated Proteins, Mitochondria, Transfection, COS Cells, GTP Phosphohydrolases, Peroxisomes, Mitochondrial Proteins, Dynamins, RNA, Small Interfering, Cell Line, Tumor, Rats

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