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Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons
Open accessAbstract
Neuronal migration is essential for the development of the mammalian brain. Here, we document severe defects in neuronal migration and reduced numbers of neurons in lamin B1–deficient mice. Lamin B1 deficiency resulted in striking abnormalities in the nuclear shape of cortical neurons; many neurons contained a solitary nuclear bleb and exhibited an asymmetric distribution of lamin B2. In contrast, lamin B2 deficiency led to increased numbers of neurons with elongated nuclei. We used conditional alleles for Lmnb1 and Lmnb2 to create forebrain-specific knockout mice. The forebrain-specific Lmnb1- and Lmnb2-knockout models had a small forebrain with disorganized layering of neurons and nuclear shape abnormalities, similar to abnormalities identified in the conventional knockout mice. A more severe phenotype, complete atrophy of the cortex, was observed in forebrain-specific Lmnb1/Lmnb2 double-knockout mice. This study demonstrates that both lamin B1 and lamin B2 are essential for brain development, with lamin B1 being required for the integrity of the nuclear lamina, and lamin B2 being important for resistance to nuclear elongation in neurons.
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“Loss of lamin B1 has been associated with cognitive decline and neurodegenerative pathology [20, 56].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [20]
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Metadata
- Authors
- Coffinier, C., Jung, H.-J., Nobumori, C., Chang, S., Tu, Y., Barnes, R. H., Yoshinaga, Y., de Jong, P. J., Vergnes, L., Reue, K., Fong, L. G., & Young, S. G.
- Affiliations
- University of California, Los Angeles (US)
- Children's Hospital Oakland Research Institute, Oakland, CA 94609
- Corresponding author
- Coffinier, Catherine
- ORCID
- Venue
- Molecular Biology of the Cell
- Published
- 2011-12
- Volume
- 22
- Issue
- 23
- Pages
- 4683-4693
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC3226484
- OpenAlex
- W1978257498
- Cited by
- 225
- References
- 41
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 9 · 2023: 13 · 2022: 17 · 2021: 23 · 2020: 14 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 20 · 2015: 12 · 2014: 21 · 2013: 19 · 2012: 14
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Molecular Biology of the Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (0722519)
- Ellison Medical Foundation
- March of Dimes Foundation
- American Heart Association
- National Institutes of Health
- University of California, Los Angeles
- U.S. Public Health Service (CJX1-44385-WS-29646)
- National Institute on Aging (R01AG035626)
- National Heart, Lung, and Blood Institute (HL89781, R01HL076839, R01HL086683, HL-86683, HL76839, R01HL089781)
- National Institute of General Medical Sciences (GM66152, R01GM066152)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050200, AR 050200)
- National Center for Research Resources (CHE-0722519)
- Division of Chemistry (CHE-0722519)
- California NanoSystems Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- lamin B1, lamin B2, neuronal migration, brain development, nuclear lamina, cortical neurons, cortical atrophy, forebrain development, conditional knockout mice
- MeSH terms
- Animals, Brain, Neurons, Prosencephalon, Mice, Knockout, Nuclear Lamina, Lamin Type B, Mice
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