Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization

Langness, Vanessa F.; van der Kant, Rik; Das, Utpal; Wang, Louie; Chaves, Rodrigo dos Santos; Goldstein, Lawrence S. B.

doi:10.1091/mbc.e20-05-0345

Cited by 41

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Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization

Langness, Vanessa F., van der Kant, Rik, Das, Utpal, Wang, Louie, Chaves, Rodrigo dos Santos, Goldstein, Lawrence S. B.·2021·Molecular Biology of the Cell

DOI 10.1091/mbc.e20-05-0345PMC PMC8098827

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Abstract

Statins reduce Aβ production by decreasing BACE1 interaction with amyloid precursor protein (APP) and enhancing APP dimerization. It is suggested that this process is regulated through competition between APP dimerization and APP cholesterol binding.

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Statins reduced β secretase processing in induced pluripotent stem cell-derived neurons.
“statins reduced β secretase processing in induced pluripotent stem cell (iPSC) –derived neurons (59).”
From Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol (2021) · cites this paper as [59]

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Sorted by citations

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
Wang, H., Kulas, J. A., Wang, C., Holtzman, D. M., Ferris, H. A., & Hansen, S. B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102191118 · Cited by 301
Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects
Feringa, F. M., & van der Kant, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.690372 · Cited by 226
Recent Advances in the Treatment of Alzheimer’s Disease Using Nanoparticle-Based Drug Delivery Systems
Poudel, P., & Park, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040835 · Cited by 124
Symptomatic and Disease-Modifying Therapy Pipeline for Alzheimer’s Disease: Towards a Personalized Polypharmacology Patient-Centered Approach
Morató, X., Pytel, V., Jofresa, S., Ruiz, A., & Boada, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169305 · Cited by 53
Aging impact on amyloid precursor protein neuronal trafficking
Burrinha, T., & Guimas Almeida, C. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102524 · Cited by 26

Authors: Langness, V. F., van der Kant, R., Das, U., Wang, L., Chaves, R. D. S., & Goldstein, L. S. B.
Affiliations: Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093
Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2021-02-01
Volume: 32
Issue: 3
Pages: 247-259
ISSN: 1059-1524
1939-4586
DOI: 10.1091/mbc.e20-05-0345
PMC: PMC8098827
Cited by: 41
References: 9
Language: en

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Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization

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