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Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein

Cho, Yoon Young, Kwon, Oh-Hoon, Park, Myoung Kyu, Kim, Tae-Wan, Chung, Sungkwon·2019·PLOS ONE
DOI 10.1371/journal.pone.0210535PMC PMC6347419
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  • The trend toward increased cholesterol in apoE4 KI mice and increased APP/GM1 clustering are consistent with increased cholesterol in familial AD patients, which leads to clustering of APP with lipid rafts and increased Aβ production in neurons expressing apoE4 isoforms.

    “The trend toward increased levels of cholesterol in apoE4 KI mice and the increased APP/GM1 clustering are consistent with the increased cholesterol in familial AD patients, which leads to the clustering of APP with lipid rafts (14) and the increased Aβ production seen in neurons expressing apoE4 isoforms (68).”

    From Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol (2021) · cites this paper as [14]

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Research works printed but not linked: 60

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Cited by

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Metadata

Authors
Cho, Y. Y., Kwon, O.-H., Park, M. K., Kim, T.-W., & Chung, S.
ORCID
Chung, Sungkwon
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2019-01-25
Volume
14
Issue
1
Pages
e0210535
ISSN
1932-6203
DOI
10.1371/journal.pone.0210535
PMC
PMC6347419
Cited by
48
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Research Foundation of Korea (2016R1D1A1A099)

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