The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
Published version of a preprint
Abstract
CRISPR-mediated genome editing in human iPSC-derived neurons is established as a model system to investigate how the lysosomal pathway is adapted to the unique demands of neurons. JIP3 and JIP4 proteins promote lysosome axonal transport in these neurons with putative relevance for Alzheimer’s disease.
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JIP4 deficiency alone has a strong effect in neurons, given that JIP3 seems to be even more critical for axonal transport, and they have at least partially redundant functions.
“It is interesting that JIP4 deficiency (likely in complex with TMEM55B) alone has such a strong effect in neurons, given that JIP3 seems to be even more critical for axonal transport, and they have been shown to have at least partially redundant functions (Gowrishankar et al., 2021).”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Gowrishankar et al., 2021
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Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
Paquet, D., Kwart, D., Chen, A., Sproul, A., Jacob, S., Teo, S., Olsen, K. M., Gregg, A., Noggle, S., & Tessier-Lavigne, M. (2016) · Nature · doi:10.1038/nature17664 · Cited by 951
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
Maday, S., Wallace, K. E., & Holzbaur, E. L. F. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201106120 · Cited by 681
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
Tian, R., Gachechiladze, M. A., Ludwig, C. H., Laurie, M. T., Hong, J. Y., Nathaniel, D., Prabhu, A. V., Fernandopulle, M. S., Patel, R., Abshari, M., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.014 · Cited by 543
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Louros, N., Ramakers, M., Michiels, E., Konstantoulea, K., Morelli, C., Garcia, T., Moonen, N., D’Haeyer, S., Goossens, V., Thal, D. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28955-9 · Cited by 28
TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles
Rudnik, S., Li, C. H., Gottschling, D.-C., Veh, A., Barbosa, D. J., Richter, J., Stroobants, S., Schuster, B., Beck, I. M., Sedlack, R., et al. (2026) · doi:10.64898/2026.10.27.762112
Metadata
- Authors
- Gowrishankar, S., Lyons, L., Rafiq, N. M., Roczniak-Ferguson, A., De Camilli, P., & Ferguson, S. M.
- Affiliations
- Departments of Cell Biology and
- Venue
- Molecular Biology of the Cell
- Published
- 2021-05-15
- Volume
- 32
- Issue
- 11
- Pages
- 1094-1103
- ISSN
- 1059-1524
- 1939-4586
- PMC
- PMC8351540
- Cited by
- 62
- References
- 4
- Language
- en
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