Cited by 62

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Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

Gowrishankar, Swetha, Lyons, Lila, Rafiq, Nisha Mohd, Roczniak-Ferguson, Agnes, De Camilli, Pietro, Ferguson, Shawn M.·2021·Molecular Biology of the Cell

Published version of a preprint

Abstract

CRISPR-mediated genome editing in human iPSC-derived neurons is established as a model system to investigate how the lysosomal pathway is adapted to the unique demands of neurons. JIP3 and JIP4 proteins promote lysosome axonal transport in these neurons with putative relevance for Alzheimer’s disease.

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Crossref · 10.1091/mbc.e20-06-0382

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  • JIP4 deficiency alone has a strong effect in neurons, given that JIP3 seems to be even more critical for axonal transport, and they have at least partially redundant functions.

    “It is interesting that JIP4 deficiency (likely in complex with TMEM55B) alone has such a strong effect in neurons, given that JIP3 seems to be even more critical for axonal transport, and they have been shown to have at least partially redundant functions (Gowrishankar et al., 2021).”

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Metadata

Authors
Gowrishankar, S., Lyons, L., Rafiq, N. M., Roczniak-Ferguson, A., De Camilli, P., & Ferguson, S. M.
Affiliations
Departments of Cell Biology and
Venue
Molecular Biology of the Cell
Published
2021-05-15
Volume
32
Issue
11
Pages
1094-1103
ISSN
  • 1059-1524
  • 1939-4586
Cited by
62
References
4
Language
en

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