Cited by 5Microtubule and mitosis dynamicsTrypanosoma species research and implicationsGenomics and Chromatin Dynamics

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Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei

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Published version of a preprint

Abstract

Little is known about the mechanism of kinetochore assembly in evolutionarily divergent eukaryotes called kinetoplastids, which have a unique set of kinetochore proteins. In this study, the authors have characterized two homologous kinetoplastid kinetochore proteins (KKT2 and KKT3) and identified their interaction partners.

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Metadata

Authors
Ishii, M., Ludzia, P., Marcianò, G., Allen, W., Nerusheva, O. O., & Akiyoshi, B.
Affiliations
  • University of Oxford (GB)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Akiyoshi, Bungo
Venue
Molecular Biology of the Cell
Published
2022-12-01
Volume
33
Issue
14
Pages
ar143-ar143
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
OpenAlex
W4296552599
Cited by
5
References
3
Citations by year
2026: 2 · 2024: 1 · 2023: 2
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Molecular Biology of the Cell (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc-sa)
Funders
  • European Molecular Biology Organization
  • Pennsylvania State University
  • Wellcome Trust (210622, 210622/Z/18/Z)
  • Toyobo Biotechnology Foundation
  • University of Warwick
  • Boehringer Ingelheim Fonds
  • Warwick Medical School
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
kinetochore assembly, Trypanosoma brucei, kinetoplastids, protein-protein interaction, kinetochore proteins, mitosis, protein binding partners
MeSH terms
Centromere, Trypanosoma brucei brucei, Protozoan Proteins, Kinetochores, Cell Cycle Proteins, Chromosome Segregation

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