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Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease
Abstract
In a case/control study, serum concentrations of vitamins A and E and major carotenoids were determined in patients with Alzheimer's disease, multi-infarct dementia and control subjects. The results showed that both Alzheimer's and multi-infarct dementia patients had significantly lower levels of vitamin E and beta-carotene than controls (vitamin E: 18.65 +/- 3.62 mumol/l in Alzheimer's disease and 15.80 +/- 6.93 mumol/l in multi-infarct dementia versus 30.03 +/- 12.03 mumol/l in controls; beta-carotene less than 0.13 to 0.42 mumol/l in Alzheimer's disease and less than 0.13 to 0.30 mumol/l in multi-infarct dementia versus 0.13 to 1.53 mumol/l in controls). Vitamin A was significantly reduced only in the Alzheimer's patients (1.56 +/- 0.78 mumol/l in Alzheimer's disease versus 2.13 +/- 0.86 mumol/l in controls).
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Cited by
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Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Association of vitamin E and C supplement use with cognitive function and dementia in elderly men
Masaki, K. H., Losonczy, K. G., Izmirlian, G., Foley, D. J., Ross, G. W., Petrovitch, H., Havlik, R., & White, L. R. (2000) · Neurology · doi:10.1212/wnl.54.6.1265 · Cited by 330
Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B. (2001) · Neurochemical Research · doi:10.1023/a:1010955807739 · Cited by 263
Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease
Foy, C. J. (1999) · QJM · doi:10.1093/qjmed/92.1.39 · Cited by 235
Biomarkers for the Early Detection and Progression of Alzheimer's Disease
Counts, S. E., Ikonomovic, M. D., Mercado, N., Vega, I. E., & Mufson, E. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-016-0481-z · Cited by 224
Metadata
- Authors
- ZAMAN, Z., ROCHE, S., FIELDEN, P., FROST, P. G., NIRIELLA, D. C., & CAYLEY, A. C. D.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 1992
- Volume
- 21
- Issue
- 2
- Pages
- 91-94
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W1976792807
- Cited by
- 202
- References
- 0
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- ZAMAN, Z., ROCHE, S., FIELDEN, P., FROST, P. G., NIRIELLA, D. C., & CAYLEY, A. C. D. (1992). Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease. Age and Ageing. https://doi.org/10.1093/ageing/21.2.91
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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