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The frailty index in Europeans: association with age and mortality

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Romero-Ortuno, Roman, Kenny, Rose Anne·2012·Age and Ageing

Abstract

BACKGROUND: the frailty index (FI) is an approach to the operationalisation of frailty based on accumulation of deficits. It has been less studied in Europeans. OBJECTIVE: to construct sex-specific FIs from a large sample of Europeans and study their associations with age and mortality. DESIGN: longitudinal population-based survey. SETTING: the Survey of Health, Ageing and Retirement in Europe (SHARE, http://share-dev.mpisoc.mpg.de/). SUBJECTS: a total of 16,217 females and 13,688 males aged ≥50 from wave 1 (2004-05). Mortality data were collected between 2005 and 2006 (mean follow-up: 2.4 years). METHODS: regression curve estimations between age and an FI constructed as per the standard procedure. Logistic regressions were used to assess the relative effects of age and the FI towards mortality. RESULTS: in both sexes, there was a significant non-linear association between age and the FI (females: quadratic R(2) = 0.20, P < 0.001; males: quadratic R(2) = 0.14, P < 0.001). Overall, the FI was a much stronger predictor of mortality than age, even after adjusting for the latter (females: age-adjusted OR 100.5, 95% confidence interval (CI): 46.3-218.2, P < 0.001; males: age-adjusted OR 221.1, 95% CI: 106.7-458.4, P < 0.001). CONCLUSION: the FI had the expected properties in this large sample of Europeans.

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Metadata

Authors
Romero-Ortuno, R., & Kenny, R. A.
Venue
Age and Ageing
Published
2012-04-19
Volume
41
Issue
5
Pages
684-689
ISSN
  • 0002-0729 (ISSN-L)
  • 1468-2834
OpenAlex
W2096891713
Cited by
215
References
5
FWCI
6.01
Type
journal article
Language
en
Open access
bronze

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Romero-Ortuno, R., & Kenny, R. A. (2012). The frailty index in Europeans: association with age and mortality. Age and Ageing. https://doi.org/10.1093/ageing/afs051

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