The incidence of Parkinson's disease in the North-East of England
Abstract
BACKGROUND: Parkinson's disease is a common disorder among older people. Accurate epidemiological information is essential to identify possible aetiological factors, plan health services and set priorities for medical research. OBJECTIVE: to determine the incidence of idiopathic Parkinson's disease in a defined geographical area in the North-East of England. METHODS: using a prospective, longitudinal design, we sought to identify every new case of Parkinson's disease arising in the Newcastle and Gateshead area in the North-East of England. The base population comprised 488 576 individuals and multiple sources of case ascertainment were employed. All the patients with newly diagnosed idiopathic Parkinson's disease or parkinsonism between 1 June 2009 and 31 May 2011 were invited to participate. Patients were examined by a specialist and followed longitudinally to permit diagnostic review. RESULTS: we identified 257 potential cases, of whom 181 had suspected idiopathic Parkinson's disease. After a follow-up period of 18 months, 155 patients retained a clinical diagnosis of probable Parkinson's disease. The mean age at diagnosis was 72.4 ± 10 years. The crude incidence of PD in Newcastle and Gateshead was 15.9 per 100 000 persons per year (95% CI: 13.4-18.4). Age-standardised to the European population the incidence of Parkinson's disease was 12.0 per 100 000 (95% CI: 10.1-14.0). We found a higher crude incidence among men 17.7 per 100 000 (95% CI: 14.0-21.4) than women 14.0 per 100 000 (95% CI: 10.7-17.4). CONCLUSION: in this prospective longitudinal study, the incidence rate of Parkinson's disease in North-East England is similar to that of other modern European and American studies.
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Incidence of Parkinson's disease increases with age.
“Incidence of Parkinson’s disease (PD), the second most common age-related neurodegenerative condition also increases with age [8,9].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [9]
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- Authors
- Duncan, G. W., Khoo, T. K., Coleman, S. Y., Brayne, C., Yarnall, A. J., O'Brien, J. T., Barker, R. A., & Burn, D. J.
- Affiliations
- Newcastle University (GB)
- Griffith University (AU)
- University of Cambridge (GB)
- Corresponding author
- Duncan, G. W.
- ORCID
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-23
- Volume
- 43
- Issue
- 2
- Pages
- 257-263
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2095993467
- Cited by
- 32
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 3
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Age and Ageing (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Griffith Research Online (submittedVersion)
- Funders
- National Institute for Health and Care Research (J-0802, NF-SI-0611-10084)
- Parkinson's UK (J-0802, G‐0502)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (J-0802)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, incidence, idiopathic Parkinson's disease, parkinsonism, sex differences, age-standardized incidence rate, Newcastle, Gateshead, North East England, older adults
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, England, Female, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease, Prospective Studies, Sex Factors, Time Factors, Incidence, Age Distribution, Sex Distribution
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