The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies
Abstract
SCOPE: it has been suggested that overweight/obesity as a risk factor for incident dementia differs between mid-life and later life. We performed a systematic review and meta-analysis of the up-to-date current literature to assess this. SEARCH METHODS: inclusion criteria included epidemiological longitudinal studies published up to September 2014, in participants without cognitive impairment based on evidence of cognitive assessment and aged 30 or over at baseline assessment with at least 2 years of follow-up. Pubmed, Medline, EMBASE, PsychInfo and the Cochrane Library were searched using combinations of the search terms: Dementia, Alzheimer disease, Vascular Dementia, Multi-Infarct Dementia, Cognitive decline, Cognitive impairment, Mild Cognitive Impairment/Obesity, Overweight, Adiposity, Waist circumference (limits: humans, English language). Handsearching of all papers meeting the inclusion criteria was performed. A random-effects model was used for the meta-analysis. RESULTS: of the 1,612 abstracts identified and reviewed, 21 completely met the inclusion criteria. Being obese below the age of 65 years had a positive association on incident dementia with a risk ratio (RR) 1.41 (95% confidence interval, CI: 1.20-1.66), but the opposite was seen in those aged 65 and over, RR 0.83 (95% CI: 0.74-0.94). CONCLUSIONS: this systematic review and meta-analysis suggests a positive association between obesity in mid-life and later dementia but the opposite in late life. Whether weight reduction in mid-life reduces risk is worthy of further study.
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Cites
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291
Anstey, K. J., Cherbuin, N., Budge, M., & Young, J. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00825.x · Cited by 855
Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., et al. (1995) · Neurology · doi:10.1212/wnl.45.6.1161 · Cited by 829
An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease
Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., & Skoog, I. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.13.1524 · Cited by 811
Midlife and Late-Life Obesity and the Risk of Dementia: Cardiovascular Health Study
Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Diehr, P., O’Meara, E. S., Longstreth, W. T., & Luchsinger, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.582 · Cited by 796
Body Mass Index in Midlife and Risk of Alzheimer Disease and Vascular Dementia
Whitmer, R., Gunderson, E., Quesenberry, C., Zhou, J., & Yaffe, K. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362047 · Cited by 430
Change in body mass index and risk of incident Alzheimer disease
Buchman, A. S., Wilson, R. S., Bienias, J. L., Shah, R. C., Evans, D. A., & Bennett, D. A. (2005) · Neurology · doi:10.1212/01.wnl.0000176061.33817.90 · Cited by 399
Relationship Between Body Mass Index and Gray Matter Volume in 1,428 Healthy Individuals
Taki, Y., Kinomura, S., Sato, K., Inoue, K., Goto, R., Okada, K., Uchida, S., Kawashima, R., & Fukuda, H. (2008) · Obesity · doi:10.1038/oby.2007.4 · Cited by 366
Vascular Risk Factors for Incident Alzheimer Disease and Vascular Dementia: The Cache County Study
Hayden, K. M., Zandi, P. P., Lyketsos, C. G., Khachaturian, A. S., Bastian, L. A., Charoonruk, G., Tschanz, J. T., Norton, M. C., Pieper, C. F., Munger, R. G., et al. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213814.43047.86 · Cited by 293
Atti, A. R., Palmer, K., Volpato, S., Winblad, B., De Ronchi, D., & Fratiglioni, L. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01458.x · Cited by 269
Cited by
Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., et al. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00249-8 · Cited by 5,575
Neurological consequences of obesity
O'Brien, P. D., Hinder, L. M., Callaghan, B. C., & Feldman, E. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30084-4 · Cited by 533
Body mass index and risk of dementia: analysis of individual-level data from 1·3 million individuals
Kivimäki, M., Luukkonen, R., Batty, G. D., Ferrie, J. E., Pentti, J., Nyberg, S. T., Shipley, M. J., Alfredsson, L., Fransson, E. I., Goldberg, M., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.09.016 · Cited by 440
Anstey, K. J., Ashby-Mitchell, K., & Peters, R. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160826 · Cited by 360
Self-citationAging, obesity, and inflammatory age-related diseases
Frasca, D., Blomberg, B. B., & Paganelli, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01745 · Cited by 371
Metadata
- Authors
- Pedditizi, E., Peters, R., & Beckett, N.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01
- Volume
- 45
- Issue
- 1
- Pages
- 14-21
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W4238608606
- Cited by
- 474
- References
- 30
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pedditizi, E., Peters, R., & Beckett, N. (2016). The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies. Age and Ageing. https://doi.org/10.1093/ageing/afv151
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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