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Cited by 219Diet, Metabolism, and DiseaseFood composition and propertiesPancreatic function and diabetes

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

The effect of coingestion of fat on the glucose, insulin, and gastric inhibitory polypeptide responses to carbohydrate and protein

Collier, G, O'Dea, K·1983·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/37.6.941
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Abstract

In the present study we examined the effect of coingestion of 50 g fat (butter) on the postprandial glucose, insulin, and gastric inhibitory polypeptide responses to 50 g carbohydrate (potato) or 50 g protein (low fat veal) in eight normal subjects. The coingestion of fat with either carbohydrate or protein resulted in greatly increased gastric inhibitory polypeptide responses, the effect being more pronounced with carbohydrate. The addition of fat to a carbohydrate meal also reduced the postprandial glucose response. This could have been due to several factors including a delayed glucose absorption, secondary to a fat-induced inhibition of gastric emptying. However, despite the lower blood glucose levels in the presence of fat the insulin response was not reduced, suggesting a potentiation of insulin secretion in the presence of fat. Thus, despite the apparent improvement in glucose tolerance when carbohydrate is ingested together with fat, the accompanying potentiation of insulin secretion could form the basis of long-term changes in insulin sensitivity which accompany alterations in dietary fat intake.

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Crossref · 10.1093/ajcn/37.6.941

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Research works printed but not linked: 2

  1. Olefsky, 1981, Mechanism of insulin resistance in obesity and non-insulin dependent (type 2) diabetes., Am I Med, 70, 1511
  2. Hunt, 1968, Regulation ofgastric emptying.In: Cook CF ed. Handbook of physiology., Section 6, Alimentary canal. Vol 4. Washington, DC: American Physiological Society, 19, 17

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Metadata

Authors
Collier, G., & O'Dea, K.
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1983-06
Volume
37
Issue
6
Pages
941-944
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/37.6.941
OpenAlex
W2166634289
Cited by
219
References
23
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 8 · 2014: 7 · 2013: 11 · 2012: 5
FWCI
7.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
postprandial blood glucose, insulin secretion, glucose-dependent insulinotropic polypeptide, carbohydrate digestion, protein digestion, gastric emptying, glucose absorption, insulin sensitivity, butter, potato, veal
MeSH terms
Adult, Blood Glucose, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Female, Gastric Inhibitory Polypeptide, Humans, Insulin, Male, Metabolism

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