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Prediction of resting energy expenditure from fat-free mass and fat mass
Abstract
On the basis of literature values, the relationship between fat-free mass (FFM), fat mass (FM), and resting energy expenditure [REE (kJ/24 h)] was determined for 213 adults (86 males, 127 females). The objectives were to develop a mathematical model to predict REE based on body composition and to evaluate the contribution of FFM and FM to REE. The following regression equations were derived: 1) REE = 1265 + (93.3 x FFM) (r2 = 0.727, P < 0.001); 2) REE = 1114 + (90.4 x FFM) + (13.2 x FM) (R2 = 0.743, P < 0.001); and 3) REE = (108 x FFM) + (16.9 x FM) (R2 = 0.986, P < 0.001). FM explained only a small part of the variation remaining after FFM was accounted for. The models that include both FFM and FM are useful in examination of the changes in REE that occur with a change in both the FFM and FM. To account for more of the variability in REE, FFM will have to be divided into organ mass and skeletal muscle mass in future analyses.
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“lean mass strongly determines heat production (metabolic rate) of the body: the greater the muscle mass, the more heat is produced by the body, even in a resting state [75,76].”
From Drivers of diversity in human thermal perception – A review for holistic comfort models (2018) · cites this paper as [75]
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“It had been hypothesized previously that non-zero intercepts in linear REE models reflect marked differences in the mass-specific metabolic rates of the individual organs and tissues that make up the metabolically active tissues of the body [9,19,27,65,66].”
BackgroundValidity of predictive equations for resting metabolic rate in healthy humans
Galgani, J. E., Castro‐Sepúlveda, M., Pérez-Luco, C., & Fernández‐Verdejo, R. (2018) · Clinical Science · doi:10.1042/cs20180317 · Cited by 17
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Amenorrhea in ballet dancers in the Netherlands
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Individual differences in the forced swimming test and neurochemical kinetics in the rat brain
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“66 70 The Correlation between measured RMRs and relevant factors The correlation between actual RMRs and various factors reportedly related to RMR-age, height, weight, body mass index, fat mass ratio, fat mass, body surface area [18-20]-is presented in Table 4.”
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“For example, fatfree mass has been considered the best single predictor of resting V̇O2, explaining 53% to 88% of the variance (Nelson et al. 1992; Owen et al. 1987; Ravussin et al. 1986).”
BackgroundMartin, B. J., MacInnis, M. J., Gillen, J. B., Skelly, L. E., & Gibala, M. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0169 · Cited by 16
“Although CGM data is clinically accurate (Radermecker et al. 2013), and it was Page 13 of 28”
MethodDifferent thermic effects of leptin in adolescent females with varying body fat content
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“It is well known that lean tissue (in particular muscle and liver mass) is the main predictor of energy expenditure (24-26).”
BackgroundDoes circulating leptin play a role in energy expenditure?
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Underweight but not underfat: is fat-free mass a key factor in constitutionally thin women?
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Lack of metabolic and behavioral adaptations in rural Gambian men with low body mass index
Bianca, P. D., Jéquier, E., & Schutz, Y. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.1.37 · Cited by 14
Self-citationVoluntary Energy Intake and Expenditure in Obese and Lean Horses Consuming ad libitum Forage
Moore, J. L., Siciliano, P. D., & Pratt-Phillips, S. E. (2018) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2018.12.020 · Cited by 13
Siddiqui, M. S., Patel, S. S., Forsgren, M. F., Bui, A. T., Shen, S., Syed, T., Boyett, S. L., Chen, S., Sanyal, A. J., Wolver, S. E., et al. (2022) · Liver International · doi:10.1111/liv.15178 · Cited by 12
“23 These findings were demonstrated in body composition analysis, which demonstrated higher fat and fat-free mass in subjects transplanted for NASH cirrhosis.”
Fernandes, T. D. O., Avesani, C. M., Kamimura, M. A., Aoike, D. T., & Cuppari, L. (2019) · Nutrition · doi:10.1016/j.nut.2019.06.008 · Cited by 12
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Weight Reduction Effect of Extract of Fermented Red Pepper on Female College Students
장은재, 김동건, 김진만, 서형주, & 오성훈 (2003) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2003.32.3.479 · Cited by 12
Wada, H., Kriengwatana, B. P., Steury, T. D., & MacDougall‐Shackleton, S. A. (2018) · Canadian Journal of Zoology · doi:10.1139/cjz-2017-0099 · Cited by 12
Iraki, J., Paulsen, G., Garthe, I., Slater, G., & Areta, J. L. (2021) · Nutrition and Health · doi:10.1177/02601060211057324 · Cited by 13
“…values for each individual with those estimated from the following predictive formulas: Nelson equation 25.8 x FFM (kg) + 4.04 x fat mass (kg) (Nelson et al., 1992), Mifflin-St Jeor equation: 9.99 x body mass (kg) + 6.25 x height (m) – 4.92 x age+ 166 x sex (men, 1; women, 0) – 161 (Mifflin…”
MethodInfluentialOoi, D. S. Q., Ling, J. Q. R., Ong, F. Y., Tai, E. S., Henry, C. J., Leow, M. K., Khoo, E. Y. H., Tan, C. S., Chong, S. C., Khoo, C. M., et al. (2021) · Nutrients · doi:10.3390/nu13124245 · Cited by 12
“In particular, an increase in lean mass is correlated with a higher RMR [5,7].”
Background
Metadata
- Authors
- Nelson, K., Weinsier, R., Long, C., & Schutz, Y.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Nelson, KM
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 56
- Issue
- 5
- Pages
- 848-856
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1954962848
- Cited by
- 371
- References
- 44
- Citations by year
- 2026: 11 · 2025: 3 · 2024: 10 · 2023: 13 · 2022: 16 · 2021: 23 · 2020: 19 · 2019: 9 · 2018: 17 · 2017: 15 · 2016: 15 · 2015: 19 · 2014: 16 · 2013: 16 · 2012: 13
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- resting energy expenditure, fat-free mass, fat mass, body composition, energy expenditure estimation, regression models, skeletal muscle mass, organ mass, adults
- MeSH terms
- Adipose Tissue, Adult, Basal Metabolism, Body Composition, Energy Metabolism, Female, Humans, Male, Mathematics, Models, Biological, Obesity, Regression Analysis
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