The DOI matches its Crossref record; 78 of the 81 references it cites were found in a registry or an index.
Physical activity as a metabolic stressor
Open accessAbstract
Both physical activity and diet stimulate processes that, over time, alter the morphologic composition and biochemical function of the body. Physical activity provides stimuli that promote very specific and varied adaptations according to the type, intensity, and duration of exercise performed. There is further interest in the extent to which diet or supplementation can enhance the positive stimuli. Prolonged walking at low intensity presents little metabolic, hormonal, or cardiovascular stress, and the greatest perturbation from rest appears to be from increased fat oxidation and plasma free fatty acid mobilization resulting from a combination of increased lipolysis and decreased reesterification. More intense jogging or running largely stimulates increased oxidation of glycogen and triacylglycerol, both of which are stored directly within the muscle fibers. Furthermore, these intramuscular stores of carbohydrate and fat appear to be the primary substrates for the enhanced oxidative and performance ability derived from endurance training-induced increases in muscle mitochondrial density. Weightlifting that produces fatigue in brief periods (ie, in 15-90 s and after 15 repetitive contractions) elicits a high degree of motor unit recruitment and muscle fiber stimulation. This is a remarkably potent stimulus for altering protein synthesis in muscle and increasing neuromuscular function. The metabolic stress of physical activity can be measured by substrate turnover and depletion, cardiovascular response, hormonal perturbation, accumulation of metabolites, or even the extent to which the synthesis and degradation of specific proteins are altered, either acutely or by chronic exercise training.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Whether directly (daily feeding) or indirectly (endogenous stores), carbohydrates, fat and protein supply the energy requirements for the human body enabling the resynthesis of ATP [26,27].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [26]
In the citing paper
“Although muscle glycogen plays a central role in energy metabolism during moderate to high intensity exercise, the importance of other extra-muscular carbohydrate sources (e.g., liver glycogen and lactate) is profound when performing prolonged exercise [26].”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [26]
In the citing paper
“Although carbohydrates are a preferred substrate during moderate to high-intensity exercise and are likely to determine exercise capacity during such endurance activities [26,131]”
From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [26]
Citations
Cites
Physical Activity and Health: A Report of the Surgeon General
(1995) · PsycEXTRA Dataset · doi:10.1037/e525162010-001 · Cited by 5,488
Physiology of Sport and Exercise
Wilmore, J. H., COSTILL, D. L., & Gleim, G. W. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199505000-00024 · Cited by 2,240
Data on the distribution of fibre types in thirty-six human muscles
Johnson, M. A., Polgar, J., Weightman, D., & Appleton, D. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90023-3 · Cited by 2,200
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
Holloszy, J. O., & Coyle, E. F. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.4.831 · Cited by 1,985
Romijn, J. A., Coyle, E. F., Sidossis, L. S., Gastaldelli, A., Horowitz, J. F., Endert, E., & Wolfe, R. R. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e380 · Cited by 1,747
Self-citationCellular mechanisms of muscle fatigue
Fitts, R. H. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.49 · Cited by 1,537 · cited 3×
“Muscle blood flow is impeded during intense contraction, which in combination with high rates of energy expenditure, makes the exercising muscles hypoxic (74).”
BackgroundEssentials of Strength Training and Conditioning
Baechle, T. R., & Earle, R. (1994) · Cited by 1,535
Maximal perfusion of skeletal muscle in man.
Andersen, P., & Saltin, B. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015794 · Cited by 1,250
Rowell, L. B. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199312000-00021 · Cited by 1,099
Research works printed but not linked: 2
- 1990, The recommended quantity and quality of exercise for developing and maintaining cardiovascular and muscular fitness in healthy adults, Med Sci Sports Exerc, 22, 265
- Costill, 1977, Effects of elevated plasma FA and insulin on muscle glycogen usage during exercise, J Appl Physiol, 43, 695, 10.1152/jappl.1977.43.4.695 · DOI · Paper page
Cited by
Sorted by citations
The Effects of Stress on Physical Activity and Exercise
Stults-Kolehmainen, M. A., & Sinha, R. (2014) · Sports Medicine · doi:10.1007/s40279-013-0090-5 · Cited by 1,192
The Scientific Basis for High-Intensity Interval Training
Laursen, P. B., & Jenkins, D. G. (2002) · Sports Medicine · doi:10.2165/00007256-200232010-00003 · Cited by 1,089
Carbohydrates for training and competition
Burke, L. M., Hawley, J. A., Wong, S. H. S., & Jeukendrup, A. E. (2011) · Journal of Sports Sciences · doi:10.1080/02640414.2011.585473 · Cited by 985
Physiological regulation of lipoprotein lipase
Kersten, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.03.013 · Cited by 574
Ha, E. Y. W., & Zemel, M. B. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00030-5 · Cited by 457
Metadata
- Authors
- Coyle, E. F.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Coyle, Edward F
- ORCID
- Coyle, Edward F
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 72
- Issue
- 2
- Pages
- 512S-520S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2139093186
- Cited by
- 174
- References
- 81
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- physical activity, metabolic stress, exercise training, substrate turnover, fat oxidation, lipolysis, triacylglycerol oxidation, mitochondrial density, muscle protein synthesis, neuromuscular function, endurance training, resistance training, dietary supplementation, endocrine response, cardiovascular response
- MeSH terms
- Adenosine Triphosphate, Adult, Blood Glucose, Cardiovascular System, Fatty Acids, Glycogen, Humans, Oxygen Consumption, Physical Endurance, Stress, Physiological, Triglycerides, Weight Lifting, Exercise, Muscle, Skeletal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
