Cited by 3,204Vitamin D Research StudiesParathyroid Disorders and TreatmentsVitamin K Research Studies

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Decreased bioavailability of vitamin D in obesity

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Wortsman, Jacobo, Matsuoka, Lois Y, Chen, Tai C, Lu, Zhiren, Holick, Michael F·2000·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/72.3.690

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Abstract

Background Obesity is associated with vitamin D insufficiency and secondary hyperparathyroidism.Objective This study assessed whether obesity alters the cutaneous production of vitamin D(3) (cholecalciferol) or the intestinal absorption of vitamin D(2) (ergocalciferol).Design Healthy, white, obese [body mass index (BMI; in kg/m(2)) > or = 30] and matched lean control subjects (BMI </= 25) received either whole-body ultraviolet radiation or a pharmacologic dose of vitamin D(2) orally.Results Obese subjects had significantly lower basal 25-hydroxyvitamin D concentrations and higher parathyroid hormone concentrations than did age-matched control subjects. Evaluation of blood vitamin D(3) concentrations 24 h after whole-body irradiation showed that the incremental increase in vitamin D(3) was 57% lower in obese than in nonobese subjects. The content of the vitamin D(3) precursor 7-dehydrocholesterol in the skin of obese and nonobese subjects did not differ significantly between groups nor did its conversion to previtamin D(3) after irradiation in vitro. The obese and nonobese subjects received an oral dose of 50000 IU (1.25 mg) vitamin D(2). BMI was inversely correlated with serum vitamin D(3) concentrations after irradiation (r = -0.55, P: = 0.003) and with peak serum vitamin D(2) concentrations after vitamin D(2) intake (r = -0.56, P: = 0.007).Conclusions Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D(3) from cutaneous and dietary sources because of its deposition in body fat compartments.

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Authors: Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F.
Affiliations: SIU Medicine (US)
ORCID: Chen, Tai C
Holick, Michael F
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2000-09
Volume: 72
Issue: 3
Pages: 690-693
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/72.3.690
OpenAlex: W2157304718
Cited by: 3,204
References: 19
Citations by year: 2026: 73 · 2025: 89 · 2024: 97 · 2023: 138 · 2022: 190 · 2021: 173 · 2020: 177 · 2019: 158 · 2018: 183 · 2017: 194 · 2016: 189 · 2015: 213 · 2014: 215 · 2013: 231 · 2012: 193
FWCI: 5.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8214 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR369637)
National Center for Research Resources (MO1 RR 00533, M01RR000533)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Keywords: obesity, vitamin D bioavailability, vitamin D insufficiency, 25-hydroxyvitamin D, parathyroid hormone, secondary hyperparathyroidism, UV irradiation, 7-dehydrocholesterol, previtamin D3, vitamin D2, body fat storage
MeSH terms: Adult, Biological Availability, Cholecalciferol, Ergocalciferols, Humans, Intestinal Absorption, Obesity, Reference Values, Skin, Ultraviolet Rays, Vitamin D, Body Mass Index

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Decreased bioavailability of vitamin D in obesity

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