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Cited by 250Food composition and propertiesLipoproteins and Cardiovascular HealthNutritional Studies and Diet

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial

Open access
Jenkins, David JA, Kendall, Cyril WC, Vuksan, Vladimir, Vidgen, Edward, Parker, Tina, Faulkner, Dorothea, Mehling, Christine C, Garsetti, Marcella, Testolin, Giulio, Cunnane, Stephen C, Ryan, Mary Ann, Corey, Paul N·2002·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/75.5.834
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Abstract

Background The US Food and Drug Administration (FDA) approved health claims for 2 dietary fibers, beta-glucan (0.75 g/serving) and psyllium (1.78 g/serving), on the assumption that 4 servings/d would reduce cardiovascular disease risk.Objective We assessed the efficacy of this dose of fibers in reducing serum lipid risk factors for cardiovascular disease.Design Sixty-eight hyperlipidemic adults consumed a test (high-fiber) and a control low-fat (25% of energy), low-cholesterol (<150 mg/d) diet for 1 mo each in a randomized crossover study. The high-fiber diet included 4 servings/d of foods containing beta-glucan or psyllium that delivered 8 g/d more soluble fiber than did similar, unsupplemented foods in the control diet. Fasting blood samples and blood pressure readings were obtained at baseline and weeks 2 and 4, and the subjects' weight was monitored weekly.Results Compared with the control diet, the high-fiber diet reduced total cholesterol (2.1 +/- 0.7%; P = 0.003), total:HDL cholesterol (2.9 +/- 0.8%; P = 0.001), LDL:HDL cholesterol (2.4 +/- 1.0%; P = 0.015), and apolipoprotein B:A-I (1.4 +/- 0.8%; P = 0.076). Applying the Framingham cardiovascular disease risk equation to the data confirmed a reduction in risk of 4.2 +/- 1.4% (P = 0.003). Small reductions in blood pressure were found after both diets. The subjects reported no significant differences in palatability or gastrointestinal symptoms between the diets.Conclusions The reduction in serum lipid risk factors for cardiovascular disease supports the FDA's approval of a health claim for a dietary fiber intake of 4 servings/d. Although relatively small in terms of patient treatment, the reduction in cardiovascular disease risk is likely to be significant on a population basis.

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Crossref · 10.1093/ajcn/75.5.834

Cites

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Citations

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Research works printed but not linked: 4

  1. 1997, FDA final rule for federal labeling: health claims: oats and coronary heart disease, Fed Regist, 62, 3584
  2. 1998, Food labeling: health claims; soluble fiber from certain foods and coronary heart disease, Fed Regist, 63
  3. 1993, Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II), JAMA, 269, 3015, 10.1001/jama.1993.03500230097036 · DOI
  4. Fontvieille, 1988, A moderate switch from high to low glycaemic-index foods for 3 weeks improves the metabolic control of type 1 (IDDM) diabetic subjects, Diabetes Nutr Metab, 1, 139

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Metadata

Authors
Jenkins, D. J., Kendall, C. W., Vuksan, V., Vidgen, E., Parker, T., Faulkner, D., Mehling, C. C., Garsetti, M., Testolin, G., Cunnane, S. C., Ryan, M. A., & Corey, P. N.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Jenkins, David JA
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2002-05
Volume
75
Issue
5
Pages
834-839
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/75.5.834
OpenAlex
W1817501081
Cited by
250
References
28
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 14 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 12 · 2015: 8 · 2014: 15 · 2013: 16 · 2012: 12
FWCI
11.30
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
soluble dietary fiber, β-glucan, psyllium, hyperlipidemia, serum lipids, cardiovascular risk, total cholesterol, LDL/HDL ratio, Framingham risk equation, blood pressure, high-fiber diet
MeSH terms
Adult, Aged, Aged, 80 and over, Apolipoproteins, Blood Pressure, Cardiovascular Diseases, Dietary Fiber, Dose-Response Relationship, Drug, Female, Glucans, Health Status, Humans, Lipids, Male, Middle Aged, Psyllium, Risk Factors, Solubility, Drug Approval, Risk Assessment, Cross-Over Studies

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